Meta pathway lipodystrophy, dyslipidemia and hyperlipidemia (Homo sapiens)

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Familial lipase maturation factor 1 deficiencyHyperthyroidismAlcoholCancerFamilial hypobetalipoproteinemiaNephrotic syndromeDiabetes mellitusDrugsEndocrine/metabolic disordersFamilial combined hypolipidemiaFamilial GPIHBP1 deficiencyCaused byMalnutritionMalabsorptionChronic infectionsAbetalipoproteinemiaKidney failureTangier diseaseCaused byHypothyroidismNorum diseaseDyslipidemiaFamilial partial lipodystrophy(FPLD)Congenital generalized lipodystrophy(CGL)Progeria associated lipodystrophyType IIType IIIType IVHyperlipidemiaAcquired partial lipodystrophyHypolipoproteinemiaLipodystrophyType IAdipose levelsDecreased levelsAutoinflammatory lipodystrophyWithin bloodWithin adipocytesHIV-associated lipodystrophyIncreased levelsAcquired generalized lipodystrophyAcquired Acquired 3, 46Familial / congenital3, 4Familial combined hyperlipidemiaFamilial hypertriglyceridemiaFamilial hypercholesterolemiaFamilial dysbetalipoproteinemiaFamilial chylomicronemia due to LPL inhibitionFamilial apoprotein CII deficiencyFamilial hyperchylomicronemiaMixed hyperlipidemiaFamilial / congenital 5, 7CGL4CGL3CGL1CGL2FPLD6FPLD5FPLD2FPLD3FPLD4FPLD1Acquired 1Familial / congenital 2, 8Type VFamilial hypobetalipoproteinemia type 1Familial hypobetalipoproteinemia type 2


Description

Dyslipidemia is a change (either increase or decrease) of adipose levels within the blood. When there is a significant increase of this, the term hyperlipidemia is used. With a significant decrease, we talk about hypolipoproteinemia. Both hyperlipidemia and hypolipoproteinemia can be classified as either acquired or familial.

Familial hyperlipidemia can be classified in five types according to the Fredrickson classification.For this classification see Quispe et al. 2019 https://doi.org/10.5114/aoms.2019.87207.

Lipodystrophy is a change (either increase or decrease) of adipose levels within the lipid tissue deposits. Lipodystrophy is classified based on wether the disease is acquired or congenital, but also wether it is geralized (through the entire body) or partial (in specific parts of the body). This classification was based on the following information by Akinci et al. [1]

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Bibliography

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  1. Davidson, MH, Pulipati, VP; ''Hypolipidemia''; MSD MANUAL Professional Version, https://www.msdmanuals.com/professional/endocrine-and-metabolic-disorders/lipid-disorders/hypolipidemia, 2019
  2. Geller AS, Polisecki EY, Diffenderfer MR, Asztalos BF, Karathanasis SK, Hegele RA, Schaefer EJ; ''Genetic and secondary causes of severe HDL deficiency and cardiovascular disease.''; J Lipid Res, 2018 PubMed Europe PMC Scholia
  3. Akinci B, Sahinoz M, Oral E; ''Lipodystrophy Syndromes: Presentation and Treatment''; , 2000 PubMed Europe PMC Scholia
  4. Garg A; ''Clinical review#: Lipodystrophies: genetic and acquired body fat disorders.''; J Clin Endocrinol Metab, 2011 PubMed Europe PMC Scholia
  5. Berglund L, Brunzell JD, Goldberg AC, Goldberg IJ, Sacks F, Murad MH, Stalenhoef AF; ''Evaluation and treatment of hypertriglyceridemia: an Endocrine Society clinical practice guideline.''; J Clin Endocrinol Metab, 2012 PubMed Europe PMC Scholia
  6. Chait A, Brunzell JD; ''Acquired hyperlipidemia (secondary dyslipoproteinemias).''; Endocrinol Metab Clin North Am, 1990 PubMed Europe PMC Scholia
  7. Quispe R, Hendrani AD, Baradaran-Noveiry B, Martin SS, Brown E, Kulkarni KR, Banach M, Toth PP, Brinton EA, Jones SR, Joshi PH; ''Characterization of lipoprotein profiles in patients with hypertriglyceridemic Fredrickson-Levy and Lees dyslipidemia phenotypes: the Very Large Database of Lipids Studies 6 and 7.''; Arch Med Sci, 2019 PubMed Europe PMC Scholia
  8. Welty FK; ''Hypobetalipoproteinemia and abetalipoproteinemia.''; Curr Opin Lipidol, 2014 PubMed Europe PMC Scholia

History

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CompareRevisionActionTimeUserComment
134584view23:54, 22 July 2024EweitzOntology Term : 'Tangier disease' added !
134583view23:54, 22 July 2024EweitzOntology Term : 'Norum disease' added !
134582view23:53, 22 July 2024EweitzOntology Term : 'abetalipoproteinemia' added !
134581view23:52, 22 July 2024EweitzStandardize case
125316view21:46, 31 January 2023LarsgwFix references bp:DB
124892view14:14, 29 December 2022EgonwModified description
118729view10:21, 1 June 2021UlasBabayigitAdded more types to type 1 familial hyperlipidemia
118723view08:28, 1 June 2021UlasBabayigitModified description
118722view08:03, 1 June 2021UlasBabayigitExpanded on familial hypolipoproteinemia
118721view07:55, 1 June 2021UlasBabayigitOntology Term : 'familial partial lipodystrophy type 6' added !
118720view07:55, 1 June 2021UlasBabayigitOntology Term : 'familial partial lipodystrophy type 5' added !
118719view07:55, 1 June 2021UlasBabayigitOntology Term : 'familial partial lipodystrophy type 4' added !
118718view07:54, 1 June 2021UlasBabayigitOntology Term : 'familial partial lipodystrophy type 3' added !
118717view07:54, 1 June 2021UlasBabayigitOntology Term : 'familial partial lipodystrophy type 2' added !
118716view07:54, 1 June 2021UlasBabayigitOntology Term : 'familial partial lipodystrophy type 1' added !
118715view07:53, 1 June 2021UlasBabayigitOntology Term : 'congenital generalized lipodystrophy type 4' added !
118714view07:52, 1 June 2021UlasBabayigitOntology Term : 'congenital generalized lipodystrophy type 3' added !
118713view07:52, 1 June 2021UlasBabayigitOntology Term : 'congenital generalized lipodystrophy type 2' added !
118712view07:52, 1 June 2021UlasBabayigitOntology Term : 'congenital generalized lipodystrophy type 1' added !
118711view07:51, 1 June 2021UlasBabayigitOntology Term : 'acquired generalized lipodystrophy' added !
118710view07:50, 1 June 2021UlasBabayigitOntology Term : 'hyperlipoproteinemia type V' added !
118708view07:48, 1 June 2021UlasBabayigitOntology Term : 'hyperlipoproteinemia type IV' added !
118707view07:48, 1 June 2021UlasBabayigitOntology Term : 'hyperlipoproteinemia type III' added !
118706view07:47, 1 June 2021UlasBabayigitOntology Term : 'familial hypercholesterolemia' added !
118705view07:47, 1 June 2021UlasBabayigitOntology Term : 'familial combined hyperlipidemia' added !
118704view07:47, 1 June 2021UlasBabayigitOntology Term : 'familial chylomicronemia syndrome' added !
118694view07:25, 1 June 2021UlasBabayigitOntology Term : 'lipid metabolism disorder' added !
118693view07:25, 1 June 2021UlasBabayigitOntology Term : 'DOID:4' removed !
118692view07:20, 1 June 2021UlasBabayigitOntology Term : 'hypolipoproteinemia' added !
118691view07:20, 1 June 2021UlasBabayigitOntology Term : 'familial hyperlipidemia' added !
118690view07:18, 1 June 2021UlasBabayigitOntology Term : 'lipodystrophy' added !
118689view07:17, 1 June 2021UlasBabayigitOntology Term : 'DOID:3146' removed !
118688view07:17, 1 June 2021UlasBabayigitOntology Term : 'DOID:4' removed !
118672view07:01, 1 June 2021UlasBabayigitRemoved '?' and added reference to acquired hypolipoproteinemia.
118637view11:35, 31 May 2021FehrhartOntology Term : 'disease pathway' added !
118636view11:34, 31 May 2021FehrhartOntology Term : 'PW:0000001' removed !
118525view10:21, 28 May 2021UlasBabayigitExpanded the meta pathway by adding hyperlipidemia acqured and all of hypolipoproteinemia
118507view09:15, 28 May 2021UlasBabayigitAdded the familial hyperlipidemia pathways
117204view08:56, 19 May 2021UlasBabayigitAdded literature to graphical nodes
117136view09:23, 18 May 2021UlasBabayigitOntology Term : 'lipid metabolism disorder' added !
117135view09:21, 18 May 2021UlasBabayigitOntology Term : 'Disease' added !
117134view09:21, 18 May 2021UlasBabayigitOntology Term : 'Pathway Ontology' added !
117091view06:59, 17 May 2021UlasBabayigitNew pathway

External references

DataNodes

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NameTypeDatabase referenceComment
Acquired partial lipodystrophyPathwayWP5104 (WikiPathways)
Congenital generalized lipodystrophy (CGL)PathwayWP5101 (WikiPathways)
DyslipidemiaQ66291209 (Wikidata) DISEASE
Familial partial lipodystrophy (FPLD)PathwayWP5102 (WikiPathways)
HyperlipidemiaQ1079120 (Wikidata) DISEASE
HypolipoproteinemiaQ5959735 (Wikidata) DISEASE
LipodystrophyQ1538213 (Wikidata) DISEASE
Progeria associated lipodystrophyPathwayWP5103 (WikiPathways)
Type IIIPathwayWP5110 (WikiPathways)
Type IIPathwayWP5109 (WikiPathways)
Type IVPathwayWP5111 (WikiPathways)
Type IPathwayWP5108 (WikiPathways)
Type VPathwayWP5112 (WikiPathways)

Annotated Interactions

No annotated interactions

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