HIF1A and PPARG in cardiac hypertropthy (Homo sapiens)

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Triacylglyceride synthesisGlycolysis1CardiomyocyteGAPDHTPI1PathologicalstressGlyceraldehyde-3-phosphateFructose-1,6-biphosphateLDHAPyruvateDihydroxyacetonephosphateLactateGlycerol-3-phosphateLysophosphatidateTriacylglycerolDiacylglycerolGPD1GPAT3GlucoseSLC2A1PPARGHIF1AHIF1APPARGCD36Fatty acidNADHNAD+H+PiNADHNAD+H+PiAcetyl-CoACoA-SHNAD+PiNADHH+NADHH+NAD+PiMyocardial steatosisHypertrophic cardiomyopathy


Description

The genes hypoxia-inducible factor 1A and peroxisome proliferator activated receptor gamma play a role in regulating glycolysis, triacylglyceride synthesis, and ultimately hypertrophic cardiomyopathy.

This diagram is derived from figure 6D in PMID 19490906:

"Schematic representation of the coregulation of glycolysis and glycerolipid synthesis by HIF1A. Hypertrophy-induced HIF1A accumulation is predicted to simultaneously promote the transcriptional upregulation of glycolytic enzymes and the direct transcriptional activation of the PPARG promoter. PPARG activity would lead to the upregulation of its target genes, GPD1 and GPAT, leading to promotion of glycerolipid biosynthesis, culminating in TAG accumulation. A secondary level of coordination is predicted to occur via the shuttling of NADH and NAD+ between GAPDH and GPD1. Thus, coordinated regulation of both these components by HIF1A is hypothesized to favor cardiomyocyte lipid accumulation in hypertrophy."

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Ontology Terms

 

Bibliography

  1. Krishnan J, Suter M, Windak R, Krebs T, Felley A, Montessuit C, Tokarska-Schlattner M, Aasum E, Bogdanova A, Perriard E, Perriard JC, Larsen T, Pedrazzini T, Krek W; ''Activation of a HIF1alpha-PPARgamma axis underlies the integration of glycolytic and lipid anabolic pathways in pathologic cardiac hypertrophy.''; Cell Metab, 2009 PubMed Europe PMC Scholia

History

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CompareRevisionActionTimeUserComment
134929view23:56, 29 July 2024EweitzModified description
134928view23:56, 29 July 2024EweitzModified description
134924view23:16, 29 July 2024EweitzRefine alignment
134923view22:58, 29 July 2024EweitzRefine layout
134922view22:55, 29 July 2024EweitzGive pathway name more bottom margin
134921view22:53, 29 July 2024EweitzAdd background pathways for context: glycolysis, triacylglyceride synthesis
134920view21:41, 29 July 2024EweitzAdd vertical space
134919view21:41, 29 July 2024EweitzEconomize layout
134918view21:37, 29 July 2024EweitzAdd link to hypertrophic cardiomyopathy: in source text, though not source figure
134917view21:14, 29 July 2024EweitzAdd more content from source
134916view12:35, 29 July 2024EweitzAdd more content from source
134915view12:20, 29 July 2024EweitzModified title
134914view03:44, 29 July 2024EweitzOntology Term : 'lipid metabolic pathway' added !
134913view03:43, 29 July 2024EweitzOntology Term : 'hypertrophic cardiomyopathy' added !
134912view03:42, 29 July 2024EweitzModified title
134911view03:36, 29 July 2024EweitzEconomize layout
134910view03:32, 29 July 2024EweitzEconomize layout
134909view03:29, 29 July 2024EweitzOntology Term : 'cardiac muscle cell' added !
134908view03:28, 29 July 2024EweitzLabel cell type
134907view03:24, 29 July 2024EweitzAdd more content from source
134906view03:18, 29 July 2024EweitzAdd more content from source
134905view03:05, 29 July 2024EweitzAdd more from source: figure 6D in PMID 19490906
134902view22:05, 28 July 2024EweitzModified description
134901view22:05, 28 July 2024EweitzModified description
134899view21:36, 28 July 2024EweitzAdd literature reference
134898view21:35, 28 July 2024EweitzRemove obsolete, incorrect "Last modified" metadata
134897view21:34, 28 July 2024EweitzEconomize layout
134896view21:25, 28 July 2024EweitzImprove alignment, economize layout
134895view21:23, 28 July 2024EweitzIncrease font size for readability
134894view21:21, 28 July 2024EweitzStandardize case
134893view21:19, 28 July 2024EweitzEconomize layout
134892view21:16, 28 July 2024EweitzRemove HIF1A interactions that have no endpoint
119185view14:09, 21 June 2021FinterlyFixed unconnected line
107555view23:50, 19 October 2019AlexanderPicoModified description
105612view04:55, 10 August 2019KhanspersModified description
96297view16:18, 7 March 2018Fehrhartfixed connection
95512view01:15, 19 December 2017Khanspersupdated xrefs and lines
89610view12:34, 20 September 2016EveloOntology Term : 'glycolysis/gluconeogenesis pathway' added !
88642view14:59, 12 August 2016JmeliusOntology Term : 'regulatory pathway' added !
71255view21:00, 16 October 2013MaintBotAutomated update of data sources
62280view00:50, 27 April 2013MaintBotFixed HIF1A xref
58978view19:04, 21 February 2013Maguirre1Corrected Database References
58791view22:45, 20 February 2013MaintBotModified categories
58711view20:02, 19 February 2013Maguirre1Fixed References
58710view19:50, 19 February 2013Maguirre1Title
58709view19:49, 19 February 2013Maguirre1Periodical save, work in progress
58708view19:39, 19 February 2013Maguirre1New pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
Acetyl-CoAMetaboliteCHEBI:49637 (ChEBI)
CD36GeneProductENSG00000135218 (Ensembl)
CoA-SHMetaboliteCHEBI:15346 (ChEBI)
DiacylglycerolMetaboliteC00165 (KEGG Compound)
Dihydroxyacetone phosphateMetaboliteC00111 (KEGG Compound)
Fatty acidMetaboliteCHEBI:35366 (ChEBI)
Fructose-1,6- biphosphateMetaboliteC05378 (KEGG Compound)
GAPDHGeneProductENSG00000111640 (Ensembl)
GPAT3GeneProductENSG00000138678 (Ensembl)
GPD1GeneProductENSG00000167588 (Ensembl)
GlucoseMetaboliteC00031 (KEGG Compound)
Glyceraldehyde- 3-phosphateMetaboliteC00118 (KEGG Compound)
Glycerol-3- phosphateMetaboliteC00093 (KEGG Compound)
GlycolysisPathwayWP534 (WikiPathways)
H+MetaboliteCHEBI:49637 (ChEBI)
HIF1AGeneProductENSG00000100644 (Ensembl)
Hypertrophic cardiomyopathyQ1364270 (Wikidata)
LDHAGeneProductENSG00000134333 (Ensembl)
LactateMetaboliteC00186 (KEGG Compound)
LysophosphatidateMetaboliteC00681 (KEGG Compound)
Myocardial steatosisQ1615518 (Wikidata)
NAD+MetaboliteCHEBI:15846 (ChEBI)
NADHMetaboliteCHEBI:16908 (ChEBI)
PPARGGeneProductENSG00000132170 (Ensembl)
Pathological stressQ123414 (Wikidata)
PiMetaboliteCHEBI:28659 (ChEBI)
PyruvateMetaboliteC00022 (KEGG Compound)
SLC2A1GeneProductENSG00000117394 (Ensembl)
TPI1GeneProductENSG00000111669 (Ensembl)
Triacylglyceride synthesisPathwayWP325 (WikiPathways)
TriacylglycerolMetaboliteC00422 (KEGG Compound)

Annotated Interactions

No annotated interactions

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