Focal adhesion (Homo sapiens)
From WikiPathways
Description
Cell-matrix adhesions play essential roles in important biological processes including cell motility, cell proliferation, cell differentiation, regulation of gene expression and cell survival. At the cell-extracellular matrix contact points, specialized structures are formed and termed focal adhesions, where bundles of actin filaments are anchored to transmembrane receptors of the integrin family through a multi-molecular complex of junctional plaque proteins. Some of the constituents of focal adhesions participate in the structural link between membrane receptors and the actin cytoskeleton, while others are signalling molecules, including different protein kinases and phosphatases, their substrates, and various adapter proteins. Integrin signaling is dependent upon the non-receptor tyrosine kinase activities of the FAK and src proteins as well as the adaptor protein functions of FAK, src and Shc to initiate downstream signaling events. These signalling events culminate in reorganization of the actin cytoskeleton; a prerequisite for changes in cell shape and motility, and gene expression. Similar morphological alterations and modulation of gene expression are initiated by the binding of growth factors to their respective receptors, emphasizing the considerable crosstalk between adhesion- and growth factor-mediated signalling.
Proteins on this pathway have targeted assays available via the CPTAC Assay Portal
Quality Tags
Ontology Terms
Bibliography
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- Parsons JT; ''Focal adhesion kinase: the first ten years.''; J Cell Sci, 2003 PubMed Europe PMC Scholia
- Mitra SK, Hanson DA, Schlaepfer DD; ''Focal adhesion kinase: in command and control of cell motility.''; Nat Rev Mol Cell Biol, 2005 PubMed Europe PMC Scholia
- Stupack DG, Cheresh DA; ''Get a ligand, get a life: integrins, signaling and cell survival.''; J Cell Sci, 2002 PubMed Europe PMC Scholia
- Schlaepfer DD, Mitra SK; ''Multiple connections link FAK to cell motility and invasion.''; Curr Opin Genet Dev, 2004 PubMed Europe PMC Scholia
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- Hlobilkovأƒآ، A, Knillovأƒآ، J, Bأƒآ،rtek J, Lukأƒآ،s J, Kolأƒآ،r Z; ''The mechanism of action of the tumour suppressor gene PTEN.''; Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub, 2003 PubMed Europe PMC Scholia
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- Burridge K, Wennerberg K; ''Rho and Rac take center stage.''; Cell, 2004 PubMed Europe PMC Scholia
- Vanhaesebroeck B, Alessi DR; ''The PI3K-PDK1 connection: more than just a road to PKB.''; Biochem J, 2000 PubMed Europe PMC Scholia
- Comoglio PM, Boccaccio C, Trusolino L; ''Interactions between growth factor receptors and adhesion molecules: breaking the rules.''; Curr Opin Cell Biol, 2003 PubMed Europe PMC Scholia
- Petit V, Thiery JP; ''Focal adhesions: structure and dynamics.''; Biol Cell, 2000 PubMed Europe PMC Scholia
History
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External references
DataNodes
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Name | Type | Database reference | Comment |
---|---|---|---|
ACTB | GeneProduct | 60 (Entrez Gene) | |
ACTG1 | GeneProduct | 71 (Entrez Gene) | |
ACTN1 | GeneProduct | 87 (Entrez Gene) | |
ACTN4 | GeneProduct | ENSG00000130402 (Ensembl) | |
AKT1 | GeneProduct | 207 (Entrez Gene) | |
AKT2 | GeneProduct | 208 (Entrez Gene) | |
AKT3 | GeneProduct | 10000 (Entrez Gene) | |
ARHGAP35 | GeneProduct | ENSG00000160007 (Ensembl) | |
ARHGAP5 | GeneProduct | 394 (Entrez Gene) | |
BAD | GeneProduct | 572 (Entrez Gene) | |
BCAR1 | GeneProduct | 9564 (Entrez Gene) | |
BCL2 | GeneProduct | 596 (Entrez Gene) | |
BIRC2 | GeneProduct | 329 (Entrez Gene) | |
BIRC3 | GeneProduct | 330 (Entrez Gene) | |
BLK | GeneProduct | 640 (Entrez Gene) | |
BRAF | GeneProduct | 673 (Entrez Gene) | |
BUB1B-PAK6 | GeneProduct | ENSG00000259288 (Ensembl) | |
CAPN2 | GeneProduct | ENSG00000162909 (Ensembl) | |
CAV1 | GeneProduct | 857 (Entrez Gene) | CAV1; caveolin 1 caveolae protein 22kD |
CAV2 | GeneProduct | 858 (Entrez Gene) | CAV2; caveolin 2 |
CAV3 | GeneProduct | 859 (Entrez Gene) | CAV3; caveolin 3 |
CCND1 | GeneProduct | 595 (Entrez Gene) | |
CCND2 | GeneProduct | 894 (Entrez Gene) | |
CCND3 | GeneProduct | 896 (Entrez Gene) | |
CDC42 | GeneProduct | 998 (Entrez Gene) | |
CHAD | GeneProduct | 1101 (Entrez Gene) | |
COL1A1 | GeneProduct | 1277 (Entrez Gene) | |
COL1A2 | GeneProduct | 1278 (Entrez Gene) | |
COL2A1 | GeneProduct | 1280 (Entrez Gene) | |
COL4A1 | GeneProduct | 1282 (Entrez Gene) | |
COL4A2 | GeneProduct | 1284 (Entrez Gene) | |
COL4A4 | GeneProduct | 1286 (Entrez Gene) | |
COL4A6 | GeneProduct | 1288 (Entrez Gene) | |
COL5A2 | GeneProduct | 1290 (Entrez Gene) | |
COL5A3 | GeneProduct | 50509 (Entrez Gene) | |
COL6A2 | GeneProduct | 1292 (Entrez Gene) | |
COMP | GeneProduct | 1311 (Entrez Gene) | |
CRK | GeneProduct | 1398 (Entrez Gene) | |
CRKL | GeneProduct | ENSG00000099942 (Ensembl) | |
CTNNB1 | GeneProduct | 1499 (Entrez Gene) | |
Cell cycle | Pathway | WP179 (WikiPathways) | |
Cell motility | Pathway | ||
DIAPH1 | GeneProduct | ENSG00000131504 (Ensembl) | |
DOCK1 | GeneProduct | 1793 (Entrez Gene) | DOCK1; dedicator of cyto-kinesis |
EGF | GeneProduct | 1950 (Entrez Gene) | |
EGFR | GeneProduct | 1956 (Entrez Gene) | |
ELK1 | GeneProduct | 2002 (Entrez Gene) | |
EMP2 | GeneProduct | 2013 (Entrez Gene) | |
ERBB2 | GeneProduct | 2064 (Entrez Gene) | |
FGR | GeneProduct | 2268 (Entrez Gene) | |
FIGF | GeneProduct | 2277 (Entrez Gene) | |
FLNA | GeneProduct | 2316 (Entrez Gene) | |
FLNB | GeneProduct | ENSG00000136068 (Ensembl) | |
FLNC | GeneProduct | ENSG00000128591 (Ensembl) | |
FLT1 | GeneProduct | 2321 (Entrez Gene) | |
FN1 | GeneProduct | 2335 (Entrez Gene) | |
FYN | GeneProduct | 2534 (Entrez Gene) | FYN; FYN oncogene related to SRC FGR YES [EC:2.7.1.112] |
GRB2 | GeneProduct | 2885 (Entrez Gene) | GRB2; growth factor receptor-bound protein 2 |
GSK3B | GeneProduct | 2932 (Entrez Gene) | |
HCK | GeneProduct | 3055 (Entrez Gene) | |
HGF | GeneProduct | 3082 (Entrez Gene) | |
HRAS | GeneProduct | 3265 (Entrez Gene) | |
IBSP | GeneProduct | 3381 (Entrez Gene) | |
IGF1 | GeneProduct | 3479 (Entrez Gene) | |
IGF1R | GeneProduct | 3480 (Entrez Gene) | |
ILK | GeneProduct | 3611 (Entrez Gene) | ILK; integrin-linked kinase [EC:2.7.1.-] |
ITGA10 | GeneProduct | 8515 (Entrez Gene) | |
ITGA11 | GeneProduct | 22801 (Entrez Gene) | |
ITGA1 | GeneProduct | ENSG00000213949 (Ensembl) | |
ITGA2 | GeneProduct | 3673 (Entrez Gene) | |
ITGA2B | GeneProduct | 3674 (Entrez Gene) | |
ITGA3 | GeneProduct | 3675 (Entrez Gene) | |
ITGA4 | GeneProduct | 3676 (Entrez Gene) | |
ITGA5 | GeneProduct | 3678 (Entrez Gene) | |
ITGA6 | GeneProduct | 3655 (Entrez Gene) | |
ITGA7 | GeneProduct | 3679 (Entrez Gene) | |
ITGA8 | GeneProduct | 8516 (Entrez Gene) | |
ITGA9 | GeneProduct | 3680 (Entrez Gene) | |
ITGAV | GeneProduct | 3685 (Entrez Gene) | |
ITGB1 | GeneProduct | 3688 (Entrez Gene) | |
ITGB3 | GeneProduct | 3690 (Entrez Gene) | |
ITGB4 | GeneProduct | 3691 (Entrez Gene) | |
ITGB5 | GeneProduct | 3693 (Entrez Gene) | |
ITGB6 | GeneProduct | 3694 (Entrez Gene) | |
ITGB7 | GeneProduct | 3695 (Entrez Gene) | |
ITGB8 | GeneProduct | 3696 (Entrez Gene) | |
JUN | GeneProduct | 3725 (Entrez Gene) | |
KDR | GeneProduct | 3791 (Entrez Gene) | |
LAMA1 | GeneProduct | 284217 (Entrez Gene) | |
LAMA2 | GeneProduct | 3908 (Entrez Gene) | |
LAMA3 | GeneProduct | 3909 (Entrez Gene) | |
LAMA4 | GeneProduct | 3910 (Entrez Gene) | |
LAMA5 | GeneProduct | 3911 (Entrez Gene) | |
LAMB1 | GeneProduct | 3912 (Entrez Gene) | |
LAMB2 | GeneProduct | 3913 (Entrez Gene) | |
LAMB3 | GeneProduct | 3914 (Entrez Gene) | |
LAMC1 | GeneProduct | 3915 (Entrez Gene) | |
LAMC2 | GeneProduct | 3918 (Entrez Gene) | |
LAMC3 | GeneProduct | 10319 (Entrez Gene) | |
MAP2K1 | GeneProduct | 5604 (Entrez Gene) | MAP2K1; mitogen-activated protein kinase kinase 1 [EC:2.7.1.-] |
MAPK10 | GeneProduct | ENSG00000109339 (Ensembl) | |
MAPK1 | GeneProduct | 5594 (Entrez Gene) | MAPK1; mitogen-activated protein kinase 1 [EC:2.7.1.-] |
MAPK3 | GeneProduct | ENSG00000102882 (Ensembl) | MAPK4; mitogen-activated protein kinase 4 [EC:2.7.1.-] |
MAPK8 | GeneProduct | 5599 (Entrez Gene) | |
MAPK9 | GeneProduct | 5601 (Entrez Gene) | |
MET | GeneProduct | 4233 (Entrez Gene) | |
MYL10 | GeneProduct | ENSG00000106436 (Ensembl) | |
MYL12A | GeneProduct | ENSG00000101608 (Ensembl) | |
MYL12B | GeneProduct | ENSG00000118680 (Ensembl) | |
MYL2 | GeneProduct | ENSG00000111245 (Ensembl) | |
MYL5 | GeneProduct | ENSG00000215375 (Ensembl) | |
MYL7 | GeneProduct | ENSG00000106631 (Ensembl) | |
MYL9 | GeneProduct | ENSG00000101335 (Ensembl) | |
MYLK2 | GeneProduct | 85366 (Entrez Gene) | |
MYLK3 | GeneProduct | ENSG00000140795 (Ensembl) | |
MYLK | GeneProduct | 4638 (Entrez Gene) | |
MYLK4 | GeneProduct | ENSG00000145949 (Ensembl) | |
MYLPF | GeneProduct | ENSG00000180209 (Ensembl) | |
PAK1 | GeneProduct | 5058 (Entrez Gene) | |
PAK2 | GeneProduct | 5062 (Entrez Gene) | |
PAK3 | GeneProduct | 5063 (Entrez Gene) | |
PAK4 | GeneProduct | 10298 (Entrez Gene) | |
PAK6 | GeneProduct | 56924 (Entrez Gene) | |
PARVA | GeneProduct | ENSG00000197702 (Ensembl) | |
PARVB | GeneProduct | 29780 (Entrez Gene) | |
PARVG | GeneProduct | ENSG00000138964 (Ensembl) | |
PDGFA | GeneProduct | 5154 (Entrez Gene) | |
PDGFB | GeneProduct | 5155 (Entrez Gene) | |
PDGFC | GeneProduct | 56034 (Entrez Gene) | |
PDGFD | GeneProduct | 80310 (Entrez Gene) | |
PDGFRA | GeneProduct | 5156 (Entrez Gene) | |
PDGFRB | GeneProduct | 5159 (Entrez Gene) | |
PDPK1 | GeneProduct | 5170 (Entrez Gene) | |
PGF | GeneProduct | 5228 (Entrez Gene) | |
PI3K-Akt signaling pathway | Pathway | WP4172 (WikiPathways) | |
PIK3CA | GeneProduct | 5290 (Entrez Gene) | |
PIK3CB | GeneProduct | 5291 (Entrez Gene) | |
PIK3CD | GeneProduct | 5293 (Entrez Gene) | |
PIK3R1 | GeneProduct | 5295 (Entrez Gene) | |
PIK3R2 | GeneProduct | 5296 (Entrez Gene) | |
PIK3R3 | GeneProduct | ENSG00000117461 (Ensembl) | |
PIP2 | Metabolite | CHEBI:18348 (ChEBI) | |
PIP3 | Metabolite | HMDB0004249 (HMDB) | |
PIP5K1C | GeneProduct | 23396 (Entrez Gene) | |
PPP1CA | GeneProduct | ENSG00000172531 (Ensembl) | |
PPP1CB | GeneProduct | ENSG00000213639 (Ensembl) | |
PPP1CC | GeneProduct | ENSG00000186298 (Ensembl) | |
PPP1R12A | GeneProduct | 4659 (Entrez Gene) | |
PPP1R12B | GeneProduct | ENSG00000077157 (Ensembl) | |
PPP1R12C | GeneProduct | ENSG00000125503 (Ensembl) | |
PRKCA | GeneProduct | ENSG00000154229 (Ensembl) | SRC; v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian) [EC:2.7.1.112] |
PRKCB | GeneProduct | ENSG00000166501 (Ensembl) | SRC; v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian) [EC:2.7.1.112] |
PRKCG | GeneProduct | ENSG00000126583 (Ensembl) | SRC; v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian) [EC:2.7.1.112] |
PTEN | GeneProduct | 5728 (Entrez Gene) | |
PTK2 | GeneProduct | 5747 (Entrez Gene) | PTK2; PTK2 protein tyrosine kinase 2 [EC:2.7.1.112 |
PTK6 | GeneProduct | 5753 (Entrez Gene) | |
PXN | GeneProduct | 5829 (Entrez Gene) | |
Phosphatidylinositol signaling | Pathway | ||
RAC1 | GeneProduct | 5879 (Entrez Gene) | |
RAC2 | GeneProduct | 5880 (Entrez Gene) | |
RAC3 | GeneProduct | 5881 (Entrez Gene) | |
RAF1 | GeneProduct | 5894 (Entrez Gene) | RAF1; v-raf-1 murine leukemia viral oncogene homolog 1 [EC:2.7.1.-] |
RAP1A | GeneProduct | 5906 (Entrez Gene) | RAP1A; RAP1A member of RAS oncogene family |
RAP1B | GeneProduct | 5908 (Entrez Gene) | RAP1B; RAP1B member of RAS oncogene family |
RAPGEF1 | GeneProduct | 2889 (Entrez Gene) | |
RASGRF1 | GeneProduct | ENSG00000058335 (Ensembl) | |
RELN | GeneProduct | 5649 (Entrez Gene) | |
RHOA | GeneProduct | 387 (Entrez Gene) | |
ROCK1 | GeneProduct | 6093 (Entrez Gene) | |
ROCK2 | GeneProduct | 9475 (Entrez Gene) | |
Regulation of actin cytoskeleton | Pathway | WP51 (WikiPathways) | |
SHC1 | GeneProduct | 6464 (Entrez Gene) | SHC1; SHC (Src homology 2 domain containing) transforming protein 1 |
SHC2 | GeneProduct | ENSG00000129946 (Ensembl) | SHC1; SHC (Src homology 2 domain containing) transforming protein 1 |
SHC3 | GeneProduct | 53358 (Entrez Gene) | SHC3; neuronal Sh |
SHC4 | GeneProduct | ENSG00000185634 (Ensembl) | SHC1; SHC (Src homology 2 domain containing) transforming protein 1 |
SOS1 | GeneProduct | 6654 (Entrez Gene) | SOS1; son of sevenless homolog 1 (Drosophila) |
SPP1 | GeneProduct | 6696 (Entrez Gene) | |
SRC | GeneProduct | 6714 (Entrez Gene) | SRC; v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian) [EC:2.7.1.112] |
SRMS | GeneProduct | 6725 (Entrez Gene) | |
STYK1 | GeneProduct | 55359 (Entrez Gene) | |
TESK2 | GeneProduct | 10420 (Entrez Gene) | |
THBS1 | GeneProduct | 7057 (Entrez Gene) | |
THBS2 | GeneProduct | 7058 (Entrez Gene) | |
THBS3 | GeneProduct | 7059 (Entrez Gene) | |
THBS4 | GeneProduct | 7060 (Entrez Gene) | |
TLN1 | GeneProduct | 7094 (Entrez Gene) | |
TLN2 | GeneProduct | ENSG00000171914 (Ensembl) | |
TNC | GeneProduct | 3371 (Entrez Gene) | |
TNK1 | GeneProduct | 8711 (Entrez Gene) | |
TNK2 | GeneProduct | 10188 (Entrez Gene) | |
TNN | GeneProduct | 63923 (Entrez Gene) | |
TNR | GeneProduct | 7143 (Entrez Gene) | |
TNXB | GeneProduct | 7148 (Entrez Gene) | |
TXK | GeneProduct | 7294 (Entrez Gene) | |
VASP | GeneProduct | 7408 (Entrez Gene) | VASP; vasodilator-stimulated phosphoprotein |
VAV1 | GeneProduct | 7409 (Entrez Gene) | |
VAV2 | GeneProduct | ENSG00000160293 (Ensembl) | |
VAV3 | GeneProduct | ENSG00000134215 (Ensembl) | |
VCL | GeneProduct | 7414 (Entrez Gene) | VCL; vinculin |
VEGF | GeneProduct | 7422 (Entrez Gene) | |
VEGFB | GeneProduct | 7423 (Entrez Gene) | |
VEGFC | GeneProduct | 7424 (Entrez Gene) | |
VTN | GeneProduct | 7448 (Entrez Gene) | |
VWF | GeneProduct | 7450 (Entrez Gene) | |
Wnt signaling pathway | Pathway | WP428 (WikiPathways) | |
XIAP | GeneProduct | ENSG00000101966 (Ensembl) | |
ZYX | GeneProduct | 7791 (Entrez Gene) | ZYX; zyxin |
Annotated Interactions
No annotated interactions