TRAF2 and UHRF1 transcriptional reactivation of latent HIV-1 promoter (Homo sapiens)
From WikiPathways
Description
Proposed model by which TRAF2 and UHRF1 transcriptionally reactivate the latent HIV-1 promoter.
This pathway model was developed from Figure 6 in (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11005436/ Rathore et al).
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Ontology Terms
Saving...Bibliography
- Rathore U, Haas P, Easwar Kumar V, Hiatt J, Haas KM, Bouhaddou M, Swaney DL, Stevenson E, Zuliani-Alvarez L, McGregor MJ, Turner-Groth A, Ochieng' Olwal C, Bediako Y, Braberg H, Soucheray M, Ott M, Eckhardt M, Hultquist JF, Marson A, Kaake RM, Krogan NJ; ''CRISPR-Cas9 screen of E3 ubiquitin ligases identifies TRAF2 and UHRF1 as regulators of HIV latency in primary human T cells.''; mBio, 2024 PubMed Europe PMC Scholia
- Verdikt R, Bendoumou M, Bouchat S, Nestola L, Pasternak AO, Darcis G, Avettand-Fenoel V, Vanhulle C, Aït-Ammar A, Santangelo M, Plant E, Douce VL, Delacourt N, Cicilionytė A, Necsoi C, Corazza F, Passaes CPB, Schwartz C, Bizet M, Fuks F, Sáez-Cirión A, Rouzioux C, De Wit S, Berkhout B, Gautier V, Rohr O, Van Lint C; ''Novel role of UHRF1 in the epigenetic repression of the latent HIV-1.''; EBioMedicine, 2022 PubMed Europe PMC Scholia
History
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External references
DataNodes
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| Name | Type | Database reference | Comment |
|---|---|---|---|
| BIRC2 | GeneProduct | BIRC2 (HGNC)  | |
| BIRC3 | GeneProduct | BIRC3 (HGNC) | |
| CHUK | GeneProduct | CHUK (HGNC) | |
| MAP3K14 | GeneProduct | MAP3K14 (Entrez Gene) | |
| NFKB2 - p100 | GeneProduct | NFKB2 (HGNC) | |
| NFKB2 - p52 | GeneProduct | NFKB2 (HGNC) | |
| Non-canonical NF-KB signaling | Pathway | ||
| RELB | GeneProduct | RELB (HGNC) | |
| TRAF2 | GeneProduct | TRAF2 (HGNC) | |
| TRAF3 | GeneProduct | 7187 (Entrez Gene) | |
| UHRF1 | GeneProduct | UHRF1 (HGNC) |
Annotated Interactions
No annotated interactions
