LIN-12/Notch Lateral Signaling (Caenorhabditis elegans)

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1LIN-122lst-12lst-2lst-422ark-12lip-12dpy-23lst-322LET-232LET-60MPK-122sli-12unc-1012apm-1gap-122


Description

Lateral signaling targets and negative regulation of LET-23 signaling. The LIN-12/Notch pathway plays two related roles in vulval development; to prevent adjacent induced vulval precursor cells (VPCs) from both becoming 1° VPCs and to induce VPCs adjacent to the 1°VPC to take a 2° cell fate. See figure 14 in http://www.wormbook.org/chapters/www_vulvaldev/vulvaldev.pdf.

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Quality Tags

Ontology Terms

 

Bibliography

  1. Yoo AS, Bais C, Greenwald I; ''Crosstalk between the EGFR and LIN-12/Notch pathways in C. elegans vulval development.''; Science, 2004 PubMed Europe PMC Scholia
  2. Sternberg PW; ''Vulval development.''; WormBook, 2005 PubMed Europe PMC Scholia

History

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CompareRevisionActionTimeUserComment
135359view07:01, 31 August 2024EgonwConverted to use Ensembl identifiers
135294view20:52, 15 August 2024KhanspersModified description
135293view20:46, 15 August 2024Khanspersfixed unconnected
135292view20:44, 15 August 2024KhanspersModified description
135291view20:40, 15 August 2024Khansperslayout, groups
118383view13:56, 27 May 2021RaatsSfixed unconnected arrow
73849view00:50, 26 February 2014MaintBotupdating schema
53149view02:12, 30 October 2012MaintBotModified categories
48973view19:22, 2 July 2012KyookModified description
48972view19:21, 2 July 2012Kyookfixing description
48938view23:47, 29 June 2012KyookOntology Term : 'Notch signaling pathway' added !
48937view23:47, 29 June 2012Kyookfinished pathway
48936view23:43, 29 June 2012KyookPeriodical save, work in progress
48935view23:29, 29 June 2012KyookNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
LET-23GeneProductWBGene00002299 (Ensembl)
LET-60GeneProductWBGene00002335 (Ensembl)
LIN-12GeneProductWBGene00003001 (Ensembl)
MPK-1GeneProductWBGene00003401 (Ensembl)
apm-1GeneProductWBGene00000150 (Ensembl)
ark-1GeneProductWBGene00000186 (Ensembl)
dpy-23GeneProductWBGene00001082 (Ensembl)
gap-1GeneProductWBGene00001515 (Ensembl)
lip-1GeneProductWBGene00003043 (Ensembl)
lst-1GeneProductWBGene00003083 (Ensembl)
lst-2GeneProductWBGene00003084 (Ensembl)
lst-3GeneProductWBGene00003085 (Ensembl)
lst-4GeneProductWBGene00003086 (Ensembl)
sli-1GeneProductWBGene00004829 (Ensembl)
unc-101GeneProductWBGene00006829 (Ensembl)

Annotated Interactions

No annotated interactions

Retrieved from "https://classic.wikipathways.org/index.php/Pathway:WP2223"
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