RNA interference and miRNA (Caenorhabditis elegans)

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RISC ComplexRNA polymerase familySome famous miRNA'sSilencingFeedback / Spreadingpri-miRNA(primary)RNA dependentargonaute familyInhibitionNucleuspre-miRNAmiRNA processor complexOther genes involved in RNAi22nt siRNAdsRNAinhibitor / competitorPASH-1/DGCR8lin-28mut-16rde-1tsn-1RDE-2/MUT-8vig-1rrf-1DRSH-1/Droshaego-1DCR-1/Dicerrde-4lin-14ALG-2let-7RDE-3/MUT-2mut-7rrf-3ALG-1lin-41rrf-2ppw-1lin-4


Description

RNA interference (RNAi) refers to the silencing of gene expression by the overexpression of sequence-specific RNA molecules. This process is associated with a cellular and nuclear defense mechanism used to combat molecular parasites such as transposons and viruses. In addition, RNA interference has been shown to play a regulatory role in development. Work in C. elegans and other organisms have identified many key regulators and pathways necessary for this process. RNAi has been adapted into a tool for the study of gene function; through the use of RNAi, the expression of a target gene can be inhibited by the reverse engineering of a corresponding dsRNA.

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Ontology Terms

 

Bibliography

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History

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CompareRevisionActionTimeUserComment
135385view12:02, 3 September 2024EgonwAdded the Ensembl gene id for let-7 and lin-4
135366view05:22, 2 September 2024EgonwConverted to use Ensembl identifiers
73143view19:52, 6 January 2014Kyookseparated ALG-1 and ALG-2
72996view22:15, 19 December 2013Kyookadded alg-1/alg-2
72995view22:13, 19 December 2013KyookSpecify description
72992view22:03, 19 December 2013KyookOntology Term : 'small non-coding RNA pathway' added !
70979view20:05, 19 September 2013KyookModified description
68459view20:19, 5 July 2013MaintBotUpdated to 2013 gpml schema
40614view19:56, 1 March 2011MaintBotRemoved redundant pathway information and comments
32418view17:08, 15 August 2009MaintBotFixed text labels
32075view13:37, 14 August 2009MaintBotFixed group labels
29817view23:01, 2 June 2009KhanspersChanged gene symbols to IDs
21512view11:31, 14 November 2008MaintBot[[Pathway:Caenorhabditis elegans:RNA interference and miRNA]] moved to [[Pathway:WP394]]: Moved to stable identifier
11614view11:13, 17 April 2008MartijnVanIerselclarified difference between pre/pri miRNA
11527view19:32, 6 April 2008MartijnVanIerselModified categories
11526view19:27, 6 April 2008MartijnVanIerselInitial version, my personal state of knowledge
11525view19:17, 6 April 2008MartijnVanIersel
11524view19:07, 6 April 2008MartijnVanIerselPeriodical save, work in progress
11522view19:01, 6 April 2008MartijnVanIerselNew pathway

External references

DataNodes

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NameTypeDatabase referenceComment
ALG-1GeneProductWBGene00000105 (Ensembl)
ALG-2GeneProductWBGene00000106 (Ensembl)
DCR-1/DicerGeneProductWBGene00000939 (Ensembl)
DRSH-1/DroshaGeneProductWBGene00009163 (Ensembl)
PASH-1/DGCR8GeneProductWBGene00011908 (Ensembl)
RDE-2/MUT-8GeneProductWBGene00004324 (Ensembl)
RDE-3/MUT-2GeneProductWBGene00003499 (Ensembl)
ego-1GeneProductWBGene00001214 (Ensembl)
let-7GeneProductlet-7 (WormBase)
lin-14GeneProductWBGene00003003 (Ensembl)
lin-28GeneProductWBGene00003014 (Ensembl)
lin-41GeneProductWBGene00003026 (Ensembl)
lin-4GeneProductlin-4 (WormBase)
mut-16GeneProductWBGene00003508 (Ensembl)
mut-7GeneProductWBGene00003504 (Ensembl)
ppw-1GeneProductC18E3.7 (WormBase)
rde-1GeneProductWBGene00004323 (Ensembl)
rde-4GeneProductWBGene00004326 (Ensembl)
rrf-1GeneProductWBGene00004508 (Ensembl)
rrf-2GeneProductWBGene00004509 (Ensembl)
rrf-3GeneProductWBGene00004510 (Ensembl)
tsn-1GeneProductWBGene00006626 (Ensembl)
vig-1GeneProductWBGene00006924 (Ensembl)

Annotated Interactions

No annotated interactions

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