Copper homeostasis (Caenorhabditis elegans)
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Description
Adapted from figure 7 from Chun et al (see Bibliography). Cu homeostasis in worms is maintained by distinctly localized intestinal CUA-1 isoforms.
A model of Cu homeostasis in C. elegans is shown. Dietary Cu ions are transported from the lumen of the intestine to the enterocytes by an unidentified Cu importer, and CUC-1 delivers Cu to CUA-1. Under basal Cu or Cu-deficient conditions, CUA-1.1 isoform localizes to the basolateral membrane and Golgi to either export Cu ions to peripheral tissues, or to direct Cu into the secretory pathway. CUA-1.2 consistently localizes to the basolateral membrane of enterocytes regardless of Cu conditions. CUA-1.1 is redistributed to the gut-granule membranes in response to elevated Cu levels in order to promote Cu detoxification in C. elegans."
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Ontology Terms
Saving...Bibliography
- Chun H, Sharma AK, Lee J, Chan J, Jia S, Kim BE; ''The Intestinal Copper Exporter CUA-1 Is Required for Systemic Copper Homeostasis in Caenorhabditis elegans.''; J Biol Chem, 2017 PubMed Europe PMC Scholia
History
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External references
DataNodes
| Name | Type | Database reference | Comment |
|---|---|---|---|
| CUA-1.1 | GeneProduct | WBGene00000834 (Ensembl)  | |
| CUA-1.2 | GeneProduct | WBGene00000834 (Ensembl) | "CUA-1.2 consistently localizes to the basolateral membrane of enterocytes regardless of Cu conditions. " |
| CUC-1 | GeneProduct | WBGene00000835 (Ensembl) | |
| Cu | Metabolite | CHEBI:23378 (ChEBI) | |
| elemental copper | Metabolite | CHEBI:23378 (ChEBI) |
Annotated Interactions
| Source | Target | Type | Database reference | Comment |
|---|---|---|---|---|
| CUA-1.1 | Arrow | WP:CE26305 (WormBase) | "CUA-1.1 is redistributed to the gut-granule membranes in response to elevated Cu levels in order to promote Cu detoxification in C. elegans." | |
| CUA-1.2 | Arrow | WP:CE19271 (WormBase) | "CUA-1.2 consistently localizes to the basolateral membrane of enterocytes regardless of Cu conditions." Evidence: "Confocal images of transgenic animals [Pvha-6::CUA-1.2::GFP::unc-54 3’UTR] expressing CUA-1.2::GFP in the intestine in the presence of 50 μM of supplemental Cu or BCS." |
