Hallmark of cancer: non-mutational epigenetic reprogramming (Homo sapiens)
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Description
Hallmarks of Cancer: Nonmutational epigenetical programming
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Ontology Terms
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- Wang JY, Lu AQ; ''The biological function of m6A reader YTHDF2 and its role in human disease.''; Cancer Cell Int, 2021 PubMed Europe PMC Scholia
- Schöller E, Weichmann F, Treiber T, Ringle S, Treiber N, Flatley A, Feederle R, Bruckmann A, Meister G; ''Interactions, localization, and phosphorylation of the m(6)A generating METTL3-METTL14-WTAP complex.''; RNA, 2018 PubMed Europe PMC Scholia
- Durbin AD, Wang T, Wimalasena VK, Zimmerman MW, Li D, Dharia NV, Mariani L, Shendy NAM, Nance S, Patel AG, Shao Y, Mundada M, Maxham L, Park PMC, Sigua LH, Morita K, Conway AS, Robichaud AL, Perez-Atayde AR, Bikowitz MJ, Quinn TR, Wiest O, Easton J, Schönbrunn E, Bulyk ML, Abraham BJ, Stegmaier K, Look AT, Qi J; ''EP300 Selectively Controls the Enhancer Landscape of MYCN-Amplified Neuroblastoma.''; Cancer Discov, 2022 PubMed Europe PMC Scholia
- Tsiouplis NJ, Bailey DW, Chiou LF, Wissink FJ, Tsagaratou A; ''TET-Mediated Epigenetic Regulation in Immune Cell Development and Disease.''; Front Cell Dev Biol, 2020 PubMed Europe PMC Scholia
- Farooqi AA, Fayyaz S, Poltronieri P, Calin G, Mallardo M; ''Epigenetic deregulation in cancer: Enzyme players and non-coding RNAs.''; Semin Cancer Biol, 2022 PubMed Europe PMC Scholia
- Yan H, Zhang L, Cui X, Zheng S, Li R; ''Roles and mechanisms of the m(6)A reader YTHDC1 in biological processes and diseases.''; Cell Death Discov, 2022 PubMed Europe PMC Scholia
- Chen Z, Zhong X, Xia M, Zhong J; ''The roles and mechanisms of the m6A reader protein YTHDF1 in tumor biology and human diseases.''; Mol Ther Nucleic Acids, 2021 PubMed Europe PMC Scholia
- Relier S, Ripoll J, Guillorit H, Amalric A, Achour C, Boissière F, Vialaret J, Attina A, Debart F, Choquet A, Macari F, Marchand V, Motorin Y, Samalin E, Vasseur JJ, Pannequin J, Aguilo F, Lopez-Crapez E, Hirtz C, Rivals E, Bastide A, David A; ''FTO-mediated cytoplasmic m(6)A(m) demethylation adjusts stem-like properties in colorectal cancer cell.''; Nat Commun, 2021 PubMed Europe PMC Scholia
- Shi H, Wang X, Lu Z, Zhao BS, Ma H, Hsu PJ, Liu C, He C; ''YTHDF3 facilitates translation and decay of N(6)-methyladenosine-modified RNA.''; Cell Res, 2017 PubMed Europe PMC Scholia
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External references
DataNodes
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| Name | Type | Database reference | Comment |
|---|---|---|---|
| ALKBH5 | Protein | ENSG00000150867 (Ensembl)  | |
| Adenosine | In RRACH domain | ||
| CREBP | Protein | ENSG00000005339 (Ensembl) | |
| CpGs in DNA | |||
| DNMT1 | Protein | ENSG00000130816 (Ensembl) | |
| DNMT3A | Protein | ENSG00000119772 (Ensembl) | |
| DNMT3B | Protein | ENSG00000142089 (Ensembl) | |
| EP300 | Protein | ENSG00000100393 (Ensembl) | |
| EZH2 | Protein | ENSG00000106462 (Ensembl) | |
| FTO | Protein | ENSG00000140718 (Ensembl) | |
| H2/3/4 | |||
| HDAC1 | Protein | ENSG00000116478 (Ensembl) | |
| HDAC2 | Protein | ENSG00000196591 (Ensembl) | |
| METTL14 | Protein | ENSG00000167741 (Ensembl) | |
| METTL3 | Protein | NSG00000083838 (Ensembl) | |
| TET1 | Protein | ENSG00000168769 (Ensembl) | |
| TET2 | Protein | ENSG00000168769 (Ensembl) | |
| TET3 | Protein | ENSG00000182985 (Ensembl) | |
| YTHDC1 | Protein | ENSG00000169047 (Ensembl) | |
| YTHDF1 | Protein | ENSG00000162408 (Ensembl) | |
| YTHDF2 | Protein | ENSG00000118454 (Ensembl) |
|
| YTHDF3 | Protein | ENSG00000185728 (Ensembl) |
|
| m6A | |||
| mRNA | |||
| pre-mRNA |
|
Annotated Interactions
No annotated interactions
