De novo biosynthesis of purine nucleotides (Saccharomyces cerevisiae)

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Description

Purine nucleotides participate in many aspects of cellular metabolism including the structure of DNA and RNA, serving as enzyme cofactors, functioning in cellular signaling, acting as phosphate group donors, and generating cellular energy. Maintenance of the proper balance of intracellular pools of these nucleotides is critical to normal function. This occurs through a combination of de novo biosynthesis and salvage pathways for pre-existing purine bases, nucleosides and nucleotides.

The de novo biosynthetic pathway for purine nucleotides is highly conserved among organisms, but its regulation and the organization of the genes encoding the enzymes vary. This fourteen step pathway contains ten steps that branch at IMP to form AMP and GMP, each in two steps. Regulation of the pathway has been well studied in microbes such as Escherichia coli, Bacillus subtilis and Saccharomyces cerevisiae, but little is known about its regulation in higher eukaryotes (metazoa, and plants).

Source: https://pathway.yeastgenome.org/

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Ontology Terms

 

Bibliography

  1. Rébora K, Laloo B, Daignan-Fornier B; ''Revisiting purine-histidine cross-pathway regulation in Saccharomyces cerevisiae: a central role for a small molecule.''; Genetics, 2005 PubMed Europe PMC Scholia
  2. Rébora K, Desmoucelles C, Borne F, Pinson B, Daignan-Fornier B; ''Yeast AMP pathway genes respond to adenine through regulated synthesis of a metabolic intermediate.''; Mol Cell Biol, 2001 PubMed Europe PMC Scholia
  3. Escobar-Henriques M, Daignan-Fornier B; ''Transcriptional regulation of the yeast gmp synthesis pathway by its end products.''; J Biol Chem, 2001 PubMed Europe PMC Scholia
  4. ''superpathway of purine nucleotides de novo biosynthesis II ''; YeastPathways,

History

View all...
CompareRevisionActionTimeUserComment
135721view23:31, 30 October 2024Khanspersremoved GenMAPP comments
135720view23:30, 30 October 2024KhanspersOntology Term : 'nucleotide metabolic pathway' added !
135719view23:24, 30 October 2024KhanspersModified description
135718view23:23, 30 October 2024Khanspersupdated reference
135717view23:22, 30 October 2024Khanspersoverhaul
135716view22:41, 30 October 2024Khanspersoverhaul
118180view10:47, 25 May 2021EweitzModified title
97912view16:16, 23 June 2018EgonwReplaced a salt with a parent ID (from PubChem)
71893view10:20, 22 October 2013Mkutmoncahnged AICAR to metabolite and connected some lines
70262view21:45, 15 July 2013MaintBotupdated to 2013 schema
69821view14:39, 11 July 2013EgonwMarked a few DataNodes with CAS registry numbers as metabolites.
67144view10:12, 26 June 2013Christine ChichesterOntology Term : 'de novo purine biosynthetic pathway' added !
41834view04:50, 2 March 2011MaintBotRemoved redundant pathway information and comments
36663view23:01, 9 April 2010MaintBot
36627view22:33, 9 April 2010MaintBotDescription and bibliography added from SGD
21107view11:30, 14 November 2008MaintBot[[Pathway:Saccharomyces cerevisiae:De Novo Biosynthesis of Purine Nucleotides]] moved to [[Pathway:WP203]]: Moved to stable identifier
12682view07:57, 17 May 2008MaintBotautomated metabolite conversion
8684view14:06, 7 January 2008MaintBotAdded to category $category
8682view14:06, 7 January 2008M.BraymerUploaded new pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
1-(5-phosphoribosyl)-4-carboxy-5-aminoimidazoleMetabolite58564 (ChEBI)
10-formyl-THFMetabolite2800-34-2 (CAS)
10-formylTHFMetabolite
5'-P-ribosyl-4-(N-succinocarboxamide)-5-aminoimidazoleMetabolite58443 (ChEBI)
5-aminoimidazole ribonucleotideMetabolite137981 (ChEBI)
5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamideMetabolite58467 (ChEBI)
5-phospho-α-D-ribose 1-diphosphate Metabolite58017 (ChEBI)
5-phospho-β-D-ribosyl-glycineamideMetabolite58457 (ChEBI)
5-phospho-β-D-ribosylamineMetabolite58681 (ChEBI)
5-phosphoribosyl-N-formylglycineamidineMetabolite18413 (ChEBI)
ADE12GeneProductS000005164 (SGD)
ADE13GeneProductS000004351 (SGD)
ADE16GeneProductS000004018 (SGD)
ADE17GeneProductS000004727 (SGD)
ADE1GeneProductS000000070 (SGD)
ADE2GeneProductS000005654 (SGD)
ADE4GeneProductS000004915 (SGD)
ADE5,7GeneProductS000003203 (SGD)
ADE6GeneProductS000003293 (SGD)
ADE8GeneProductS000002816 (SGD)
ADK1GeneProductS000002634 (SGD)
ADK2GeneProductS000000972 (SGD)
ADPMetabolite58-64-0 (CAS)
AICARMetabolite3031-94-5 (CAS)
AMPMetabolite456215 (ChEBI)
ATPMetabolite1927-31-7 (CAS)
CO2Metabolite16526 (ChEBI)
GDPMetabolite146-91-8 (CAS)
GMPMetabolite85-32-5 (CAS)
GTPMetabolite2564-35-4 (CAS)
GUA1GeneProductS000004830 (SGD)
GUK1GeneProductS000001550 (SGD)
Glycine biosynthesisPathwayWP261 (WikiPathways)
H+Metabolite15378 (ChEBI)
H2OMetabolite15377 (ChEBI)
IMD2GeneProductS000001259 (SGD)
IMD3GeneProductS000004424 (SGD)
IMD4GeneProductS000004520 (SGD)
IMPMetabolite58053 (ChEBI)
L-aspartateMetabolite29991 (ChEBI)
L-glutamateMetabolite56-86-0 (CAS)
L-glutamineMetabolite56-85-9 (CAS)
L-glycineMetabolite56-40-6 (CAS)
NAD+Metabolite57540 (ChEBI)
NADHMetabolite53-84-9 (CAS)
RNR1GeneProductS000000872 (SGD)
RNR2GeneProductS000003563 (SGD)
RNR3GeneProductS000001328 (SGD)
RNR4GeneProductS000003412 (SGD)
THFMetabolite
YNK1GeneProductS000001550 (SGD)
adenylo-succinateMetabolite57567 (ChEBI)
dADPMetabolite57667 (ChEBI)
dATPMetabolite61404 (ChEBI)
dGDPMetabolite644 (PubChem-compound)
dGTPMetabolite61429 (ChEBI)
diphosphateMetabolite2466-09-3 (CAS)
formateMetabolite15740 (ChEBI)
fumarateMetabolite29806 (ChEBI)
phosphateMetabolite14265-44-2 (CAS)
xanthosine-5-phosphateMetabolite523-98-8 (CAS)

Annotated Interactions

No annotated interactions

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