Targeted therapy in breast cancer (Homo sapiens)
From WikiPathways
Description
"Trastuzumab and pertuzumab inhibit HER2 signaling by binding to the extracellular domain of HER2. Lapatinib, neratinib, tucatinib, and pyrotinib inhibit HER signaling by binding to the intracellular tyrosine kinase domain of the Her family members. EGFR epidermal growth factor receptor, HER human epidermal growth factor receptor, MEK MAP kinase kinase, ERK MAP kinase, PI3K phosphoinositide 3-kinases (adapted from “HER2 Signaling Pathway”, by BioRender.com (2022). Retrieved from https://app.biorender.com/biorender-templates)". Source: Figure F1, https://pmc.ncbi.nlm.nih.gov/articles/PMC9281252/. Derived from PFOCR, https://pfocr.wikipathways.org/figures/PMC9281252__12032_2022_1749_Fig1_HTML.html.
Quality Tags
Ontology Terms
Saving...Bibliography
- Demir Cetinkaya B, Biray Avci C; ''Molecular perspective on targeted therapy in breast cancer: a review of current status.''; Med Oncol, 2022 PubMed Europe PMC Scholia
History
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External references
DataNodes
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| Name | Type | Database reference | Comment |
|---|---|---|---|
| AKT1 | GeneProduct | ENSG00000142208 (Ensembl)  | |
| AKT2 | GeneProduct | ENSG00000105221 (Ensembl) | |
| AKT3 | GeneProduct | ENSG00000117020 (Ensembl) | |
| EGFR | GeneProduct | ? (Ensembl) | |
| HER2 | GeneProduct | ? (Ensembl) | |
| HER3 | GeneProduct | ? (Ensembl) | |
| HER4 | GeneProduct | ? (Ensembl) | |
| HRAS | GeneProduct | ENSG00000174775 (Ensembl) | |
| KRAS | GeneProduct | ENSG00000133703 (Ensembl) | |
| Lapatinib | Metabolite | CHEBI:49603 (ChEBI) | |
| MAP2K1 | GeneProduct | ENSG00000107356 (Ensembl) | |
| MAP2K2 | GeneProduct | ENSG00000101418 (Ensembl) | |
| MAP2K3 | GeneProduct | ENSG00000107958 (Ensembl) | |
| MAP2K4 | GeneProduct | ENSG00000115669 (Ensembl) | |
| MAP2K5 | GeneProduct | ENSG00000138015 (Ensembl) | |
| MAP2K6 | GeneProduct | ENSG00000129652 (Ensembl) | |
| MAP2K7 | GeneProduct | ENSG00000118907 (Ensembl) | |
| MAPK1 | GeneProduct | ENSG00000100030 (Ensembl) | Literature notes: "No specific YAP inhibitors are currently in clinical use, however, Truong et al. demonstrated that combined therapy with trametinib MEK1/2 inhibition and the lysosome inhibitor chloroquine increased cytotoxicity while indirectly decreasing YAP nuclear localization and transcriptional activity (Feng et al., 2019; Truong et al., 2020). Other groups have proposed GNAQ overactivation of ERK1/2 or MEK1/2 as a driver of UM, but inhibitors of this pathway alone are typically insufficient to stop progression and the degree of MAPK activation is widely heterogeneous within tumor sites" |
| MAPK3 | GeneProduct | ENSG00000102882 (Ensembl) | Literature notes: "No specific YAP inhibitors are currently in clinical use, however, Truong et al. demonstrated that combined therapy with trametinib MEK1/2 inhibition and the lysosome inhibitor chloroquine increased cytotoxicity while indirectly decreasing YAP nuclear localization and transcriptional activity (Feng et al., 2019; Truong et al., 2020). Other groups have proposed GNAQ overactivation of ERK1/2 or MEK1/2 as a driver of UM, but inhibitors of this pathway alone are typically insufficient to stop progression and the degree of MAPK activation is widely heterogeneous within tumor sites" |
| NRAS | GeneProduct | ENSG00000213281 (Ensembl) | |
| Neratinib | Metabolite | CHEBI:61397 (ChEBI) | |
| PIK3C2A | GeneProduct | ENSG00000011405 (Ensembl) | |
| PIK3C2B | GeneProduct | ENSG00000133056 (Ensembl) | |
| PIK3C2G | GeneProduct | ENSG00000139144 (Ensembl) | |
| PIK3CA | GeneProduct | ENSG00000121879 (Ensembl) | |
| PIK3CB | GeneProduct | ENSG00000051382 (Ensembl) | |
| PIK3CD | GeneProduct | ENSG00000171608 (Ensembl) | |
| PIK3CG | GeneProduct | ENSG00000105851 (Ensembl) | |
| PIK3R1 | GeneProduct | ENSG00000145675 (Ensembl) | |
| PIK3R2 | GeneProduct | ENSG00000105647 (Ensembl) | |
| PIK3R3 | GeneProduct | ENSG00000117461 (Ensembl) | |
| PIK3R4 | GeneProduct | ENSG00000196455 (Ensembl) | |
| PIK3R6 | GeneProduct | ENSG00000276231 (Ensembl) | |
| Pertuzumab | Metabolite | DB06366 (DrugBank) | |
| Pyrotinib | Metabolite | DB14993 (DrugBank) | |
| RAF1 | GeneProduct | ENSG00000132155 (Ensembl) | |
| Trastuzumab | Metabolite | DB00072 (DrugBank) | |
| Tucatinib | Metabolite |
Annotated Interactions
No annotated interactions
