Effect of dasatinib on the BCR-ABL signaling pathway (Homo sapiens)
From WikiPathways
Description
Phosphorylation sites that are found to be suppressed by Dasatinib are shown. Based on fig 6 from https://pmc.ncbi.nlm.nih.gov/articles/PMC2816010/Phosphorylation site information is based on the left-side panel in the figure; not all sites could be verified in independent sources (e.g. PhosphositePlus).
Quality Tags
Ontology Terms
Bibliography
- Pan C, Olsen JV, Daub H, Mann M; ''Global effects of kinase inhibitors on signaling networks revealed by quantitative phosphoproteomics.''; Mol Cell Proteomics, 2009 PubMed Europe PMC Scholia
History
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External references
DataNodes
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Name | Type | Database reference | Comment |
---|---|---|---|
PIK3CA | GeneProduct | 5290 (Entrez Gene) | |
PIK3R1 | GeneProduct | 5295 (Entrez Gene) | |
ABL1 | GeneProduct | 25 (Entrez Gene) | |
AKT1 | GeneProduct | 207 (Entrez Gene) | OCR lexicon match: AKT |
AKT2 | GeneProduct | 208 (Entrez Gene) | OCR lexicon match: AKT |
AKT3 | GeneProduct | 10000 (Entrez Gene) | OCR lexicon match: AKT |
ARAF | GeneProduct | 369 (Entrez Gene) | OCR lexicon match: RAF |
ATF2 | GeneProduct | 1386 (Entrez Gene) | OCR lexicon match: ATF2 |
BCAR1 | GeneProduct | 9564 (Entrez Gene) | OCR lexicon match: CAS |
BCL2 | GeneProduct | 596 (Entrez Gene) | OCR lexicon match: BCL2 |
BCL9 | GeneProduct | 607 (Entrez Gene) | |
BCLAF1 | GeneProduct | 9774 (Entrez Gene) | OCR lexicon match: BCLAF1 |
BCR | GeneProduct | 613 (Entrez Gene) | |
BRAF | GeneProduct | 673 (Entrez Gene) | OCR lexicon match: RAF |
CBL | GeneProduct | 867 (Entrez Gene) | OCR lexicon match: CBL |
CRK | GeneProduct | 1398 (Entrez Gene) | OCR lexicon match: CRK |
CRKL | GeneProduct | 1399 (Entrez Gene) | |
DOK1 | GeneProduct | 1796 (Entrez Gene) | |
EIF4B | GeneProduct | 1975 (Entrez Gene) | OCR lexicon match: EIF4B |
GAB2 | GeneProduct | 9846 (Entrez Gene) | OCR lexicon match: GAB2 |
GRB2 | GeneProduct | 2885 (Entrez Gene) | |
HRAS | GeneProduct | 3265 (Entrez Gene) | OCR lexicon match: RAS |
HSPB1 | GeneProduct | 3315 (Entrez Gene) | OCR lexicon match: HSP27 |
HSPB2 | GeneProduct | 3316 (Entrez Gene) | OCR lexicon match: HSP27 |
INPP5D | GeneProduct | 3635 (Entrez Gene) | |
JAK-STAT signaling | Pathway | ||
KRAS | GeneProduct | 3845 (Entrez Gene) | OCR lexicon match: RAS |
MAP3K2 | GeneProduct | 10746 (Entrez Gene) | OCR lexicon match: MEKK2 |
MAPK11 | GeneProduct | 5600 (Entrez Gene) | |
MAPK14 | GeneProduct | 1432 (Entrez Gene) | |
MAPK1 | GeneProduct | 5594 (Entrez Gene) | |
MAPK3 | GeneProduct | 5595 (Entrez Gene) | |
MEF2C | GeneProduct | 4208 (Entrez Gene) | OCR lexicon match: MEF2C |
NRAS | GeneProduct | 4893 (Entrez Gene) | OCR lexicon match: RAS |
PTK2 | GeneProduct | 5747 (Entrez Gene) | OCR lexicon match: FAK |
PXN | GeneProduct | 5829 (Entrez Gene) | |
RAF1 | GeneProduct | 5894 (Entrez Gene) | OCR lexicon match: RAF |
RPS6KA1 | GeneProduct | 6195 (Entrez Gene) | OCR lexicon match: RSK |
SHC1 | GeneProduct | 6464 (Entrez Gene) | OCR lexicon match: SHC |
SHC2 | GeneProduct | 25759 (Entrez Gene) | OCR lexicon match: SHC |
SHC3 | GeneProduct | 53358 (Entrez Gene) | OCR lexicon match: SHC |
SHC4 | GeneProduct | 399694 (Entrez Gene) | OCR lexicon match: SHC |
SOS1 | GeneProduct | 6654 (Entrez Gene) | |
SPAG1 | GeneProduct | 6674 (Entrez Gene) | |
SRC | GeneProduct | 6714 (Entrez Gene) | OCR lexicon match: SRC |
VAV1 | GeneProduct | 7409 (Entrez Gene) |
Annotated Interactions
No annotated interactions