Effect of dasatinib on the BCR-ABL signaling pathway (Homo sapiens)
From WikiPathways
Description
Effect of dasatinib on the BCR-ABL signaling pathway, showing phosphorylation sites that were found to be suppressed by Dasatinib are shown (Pan et al). Key signaling events in the three major MAPK cascades were suppressed, including the activation loop phosphorylation sites of p38α/β (MAPK11) and ERK1/2 (MAPK1/MAPK3).
Based on fig 6 from https://pmc.ncbi.nlm.nih.gov/articles/PMC2816010/Phosphorylation site information is based on the left-side panel in the figure; not all sites could be verified in independent sources (e.g. PhosphositePlus).
Quality Tags
Ontology Terms
Saving...Bibliography
- Pan C, Olsen JV, Daub H, Mann M; ''Global effects of kinase inhibitors on signaling networks revealed by quantitative phosphoproteomics.''; Mol Cell Proteomics, 2009 PubMed Europe PMC Scholia
History
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External references
DataNodes
| View all... |
| Name | Type | Database reference | Comment |
|---|---|---|---|
| PIK3CA | GeneProduct | 5290 (Entrez Gene)  | |
| PIK3R1 | GeneProduct | 5295 (Entrez Gene) | |
| ABL1 | GeneProduct | 25 (Entrez Gene) | |
| AKT1 | GeneProduct | 207 (Entrez Gene) | OCR lexicon match: AKT |
| AKT2 | GeneProduct | 208 (Entrez Gene) | OCR lexicon match: AKT |
| AKT3 | GeneProduct | 10000 (Entrez Gene) | OCR lexicon match: AKT |
| ARAF | GeneProduct | 369 (Entrez Gene) | OCR lexicon match: RAF |
| ATF2 | GeneProduct | 1386 (Entrez Gene) | OCR lexicon match: ATF2 |
| BCAR1 | GeneProduct | 9564 (Entrez Gene) | OCR lexicon match: CAS |
| BCL2 | GeneProduct | 596 (Entrez Gene) | OCR lexicon match: BCL2 |
| BCL9 | GeneProduct | 607 (Entrez Gene) | |
| BCLAF1 | GeneProduct | 9774 (Entrez Gene) | OCR lexicon match: BCLAF1 |
| BCR | GeneProduct | 613 (Entrez Gene) | |
| BRAF | GeneProduct | 673 (Entrez Gene) | OCR lexicon match: RAF |
| CBL | GeneProduct | 867 (Entrez Gene) | OCR lexicon match: CBL |
| CRK | GeneProduct | 1398 (Entrez Gene) | OCR lexicon match: CRK |
| CRKL | GeneProduct | 1399 (Entrez Gene) | |
| DOK1 | GeneProduct | 1796 (Entrez Gene) | |
| EIF4B | GeneProduct | 1975 (Entrez Gene) | OCR lexicon match: EIF4B |
| GAB2 | GeneProduct | 9846 (Entrez Gene) | OCR lexicon match: GAB2 |
| GRB2 | GeneProduct | 2885 (Entrez Gene) | |
| HRAS | GeneProduct | 3265 (Entrez Gene) | OCR lexicon match: RAS |
| HSPB1 | GeneProduct | 3315 (Entrez Gene) | OCR lexicon match: HSP27 |
| HSPB2 | GeneProduct | 3316 (Entrez Gene) | OCR lexicon match: HSP27 |
| INPP5D | GeneProduct | 3635 (Entrez Gene) | |
| JAK-STAT signaling | Pathway | ||
| KRAS | GeneProduct | 3845 (Entrez Gene) | OCR lexicon match: RAS |
| MAP3K2 | GeneProduct | 10746 (Entrez Gene) | OCR lexicon match: MEKK2 |
| MAPK11 | GeneProduct | 5600 (Entrez Gene) | |
| MAPK14 | GeneProduct | 1432 (Entrez Gene) | |
| MAPK1 | GeneProduct | 5594 (Entrez Gene) | |
| MAPK3 | GeneProduct | 5595 (Entrez Gene) | |
| MEF2C | GeneProduct | 4208 (Entrez Gene) | OCR lexicon match: MEF2C |
| NRAS | GeneProduct | 4893 (Entrez Gene) | OCR lexicon match: RAS |
| PTK2 | GeneProduct | 5747 (Entrez Gene) | OCR lexicon match: FAK |
| PXN | GeneProduct | 5829 (Entrez Gene) | |
| RAF1 | GeneProduct | 5894 (Entrez Gene) | OCR lexicon match: RAF |
| RPS6KA1 | GeneProduct | 6195 (Entrez Gene) | OCR lexicon match: RSK |
| SHC1 | GeneProduct | 6464 (Entrez Gene) | OCR lexicon match: SHC |
| SHC2 | GeneProduct | 25759 (Entrez Gene) | OCR lexicon match: SHC |
| SHC3 | GeneProduct | 53358 (Entrez Gene) | OCR lexicon match: SHC |
| SHC4 | GeneProduct | 399694 (Entrez Gene) | OCR lexicon match: SHC |
| SOS1 | GeneProduct | 6654 (Entrez Gene) | |
| SPAG1 | GeneProduct | 6674 (Entrez Gene) | |
| SRC | GeneProduct | 6714 (Entrez Gene) | OCR lexicon match: SRC |
| VAV1 | GeneProduct | 7409 (Entrez Gene) |
Annotated Interactions
No annotated interactions
