Heme biosynthesis (Drosophila melanogaster)
From WikiPathways
Description
The enzymatic process that produces heme is porphyrin synthesis. The process is highly conserved across biology. In humans, this pathway serves almost exclusively to form heme.
Heme biosynthesis starts with the synthesis of D-Aminolevulinic acid (dALA or δALA) from the amino acid glycine and succinyl-CoA, which is produced in the TCA cycle (Krebs cycle). This reaction is catalyzed by ALA synthase, which is a rate-limiting enzyme that is regulated by intracellular glucose and heme levels.
The major organs for heme synthesis are the liver and the bone marrow.
Source: Adapted from [Wikipedia](https://en.wikipedia.org/wiki/Heme).Quality Tags
Ontology Terms
Saving...Bibliography
No bibliography
History
View all... |
External references
DataNodes
| View all... |
| Name | Type | Database reference | Comment |
|---|---|---|---|
| 2 CO₂ | Metabolite | CHEBI:16526 (ChEBI)  | |
| 2 H+ | Metabolite | ||
| 2 H₂O | Metabolite | CHEBI:15377 (ChEBI) | |
| 4 CO₂ | Metabolite | CHEBI:16526 (ChEBI) | |
| 4 NH3 | Metabolite | ||
| ALAS1 | GeneProduct | ||
| Alas | GeneProduct | 37815 (Entrez Gene) | |
| CG1885 | GeneProduct | 31817 (Entrez Gene) | |
| CO₂ | Metabolite | CHEBI:16526 (ChEBI) | |
| CoA | Metabolite | CHEBI:15346 (ChEBI) | |
| Coprox | GeneProduct | 44701 (Entrez Gene) | |
| Fe2+ | Metabolite | CHEBI:29033 (ChEBI) | |
| H₂O | Metabolite | CHEBI:15377 (ChEBI) | |
| H₂O₂ | Metabolite | ||
| O₂ | Metabolite | CHEBI:15379 (ChEBI) | |
| Pbgs | GeneProduct | 39402 (Entrez Gene) | |
| Ppox | GeneProduct | 42939 (Entrez Gene) | |
| Updo | GeneProduct | 35986 (Entrez Gene) | |
| coproporphyrinogen III | Metabolite | ||
| delta-aminolevulinate | Metabolite | ||
| delta-aminolevulinate | Metabolite | CHEBI:17549 (ChEBI) | |
| ferrochelatase | GeneProduct | 43757 (Entrez Gene) | |
| glycine | Metabolite | CHEBI:15428 (ChEBI) | |
| hydroxymethylbilane | Metabolite | ||
| l(3)02640 | GeneProduct | 46140 (Entrez Gene) | |
| porphobilinogen | Metabolite | ||
| protoheme | Metabolite | ||
| protoporphyrin IX | Metabolite | ||
| protoporphyrinogen IX | Metabolite | ||
| succinyl-CoA | Metabolite | CHEBI:15380 (ChEBI) | |
| uroporphyrinogen III | Metabolite |
Annotated Interactions
No annotated interactions
