Proteasome degradation (Rattus norvegicus)

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Description

Degradation by proteasomes is part of the mechanism by which cells regulate the concentration of proteins and degrade misfolded proteins. Proteasomes are protein complexes which degrade unneeded or damaged proteins by proteolysis, a chemical reaction that breaks peptide bonds. Proteins are tagged for degradation by proteasomes by the addition of ubiquitin, by ubiquitin ligases. Description adapted from [Wikipedia](https://en.wikipedia.org/wiki/Proteasome).

Comments

HomologyMapper 
This pathway was inferred from Homo sapiens pathway WP183 (r95110) with a 86.0% conversion rate.

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Quality Tags

Ontology Terms

 

Bibliography

  1. Hershko A, Ciechanover A, Varshavsky A; ''Basic Medical Research Award. The ubiquitin system.''; Nat Med, 2000 PubMed Europe PMC Scholia
  2. Lasker K, Förster F, Bohn S, Walzthoeni T, Villa E, Unverdorben P, Beck F, Aebersold R, Sali A, Baumeister W; ''Molecular architecture of the 26S proteasome holocomplex determined by an integrative approach.''; Proc Natl Acad Sci U S A, 2012 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
141390view18:28, 11 November 2025EgonwModified description
117012view11:22, 16 May 2021EweitzModified title
95795view14:41, 19 January 2018MkutmonHomology conversion update
72157view11:58, 25 October 2013EgonwAdded a metabolite ID.
71801view20:34, 17 October 2013MaintBotAutomated update of data sources
71306view16:59, 17 October 2013MaintBotAutomated update of data sources
69432view19:04, 8 July 2013MaintBotUpdated to 2013 gpml schema
67613view11:33, 26 June 2013DdiglesOntology Term : 'ubiquitin/proteasome degradation pathway' added !
62852view05:06, 3 May 2013MaintBotUpdated UniProt data source
58967view18:39, 21 February 2013MaintBotUpdated Ensembl and UniProt data source
41756view02:41, 2 March 2011MaintBotRemoved redundant pathway information and comments
34126view19:28, 9 December 2009MaintBotAutomatic update of empty xrefs
32391view16:59, 15 August 2009MaintBotFixed text labels
32039view13:28, 14 August 2009MaintBotFixed group labels
31426view21:00, 13 August 2009MaintBotFixed text labels
31020view01:08, 30 July 2009MaintBotConverted from Homo sapiens
21315view11:31, 14 November 2008MaintBot[[Pathway:Rattus norvegicus:Proteasome Degradation]] moved to [[Pathway:WP302]]: Moved to stable identifier
8352view13:46, 7 January 2008MaintBot[[Pathway:Rat:Proteasome Degradation]] moved to [[Pathway:Rattus norvegicus:Proteasome Degradation]]: Renaming species
7794view16:18, 18 December 2007MaintBotfixed category names
7487view12:42, 4 November 2007MaintBotAdded categories to GPML
6588view22:20, 22 May 2007Nsalomonisgpml file for [[Rat:Proteasome_Degradation]]

External references

DataNodes

View all...
NameTypeDatabase referenceComment
AABR07045621.1GeneProductENSRNOG00000049150 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:5687
ATPMetabolite1927-31-7 (CAS)
H2AFZGeneProductENSRNOG00000031564 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:3015
H2afxGeneProductENSRNOG00000010386 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:3014
HIST1H2ABGeneProductNo homologues found for original id L:8335
HLA-HGeneProduct
HLA-JGeneProduct
IfngGeneProductENSRNOG00000007468 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:3458
LOC100360846GeneProductENSRNOG00000011827 (Ensembl)
  • U13393
  • Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:5694
Nedd4GeneProductENSRNOG00000058898 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:4734
PSMA1GeneProductNo homologues found for original id L:5682
PSMB3GeneProductNo homologues found for original id L:5691
PSMD10GeneProductNo homologues found for original id L:5716
Psma2GeneProductENSRNOG00000049920 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:5683
Psma3GeneProductENSRNOG00000007851 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:5684
Psma4GeneProductENSRNOG00000013493 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:5685
Psma5GeneProductENSRNOG00000019868 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:5686
Psma7GeneProductENSRNOG00000056853 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:5688
Psmb10GeneProductENSRNOG00000019494 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:5699
Psmb1GeneProductENSRNOG00000001488 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:5689
Psmb2GeneProductENSRNOG00000011463 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:5690
Psmb4GeneProductENSRNOG00000020979 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:5692
Psmb5GeneProductENSRNOG00000013386 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:5693
Psmb7GeneProductENSRNOG00000011732 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:5695
Psmb8GeneProductENSRNOG00000000456 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:5696
Psmb9GeneProductENSRNOG00000000459 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:5698
Psmc1GeneProductENSRNOG00000003951 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:5700
Psmc2GeneProductENSRNOG00000012026 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:5701
Psmc3GeneProductENSRNOG00000011414 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:5702
Psmc4GeneProductENSRNOG00000018994 (Ensembl)
  • PRS6 HUMAN
  • Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:5704
Psmc5GeneProductENSRNOG00000010038 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:5705
Psmc6GeneProductENSRNOG00000007203 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:5706
Psmd11GeneProductENSRNOG00000005538 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:5717
Psmd12GeneProductENSRNOG00000003117 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:5718
Psmd13GeneProductENSRNOG00000014109 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:5719
Psmd1GeneProductENSRNOG00000017730 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:5707
Psmd2GeneProductENSRNOG00000001719 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:5708
Psmd3GeneProductENSRNOG00000028103 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:5709
Psmd4GeneProductENSRNOG00000021042 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:5710
Psmd5GeneProductENSRNOG00000018809 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:5711
Psmd6GeneProductENSRNOG00000006751 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:9861
Psmd7GeneProductENSRNOG00000014097 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:5713
Psmd8GeneProductENSRNOG00000037580 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:5714
Psmd9GeneProductENSRNOG00000001339 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:5715
Psme1GeneProductENSRNOG00000019041 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:5720
Psme2GeneProductENSRNOG00000019246 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:5721
Psme3GeneProductENSRNOG00000051344 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:10197
RT1-M6-1GeneProductENSRNOG00000022107 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:3106
Rpn1GeneProductENSRNOG00000046345 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:6184
Rpn2GeneProductENSRNOG00000007492 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:6185
UBBGeneProductNo homologues found for original id En:ENSG00000170315
UBCGeneProductNo homologues found for original id L:7316
Uba1GeneProductENSRNOG00000019164 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:7317
Uba7GeneProductENSRNOG00000029195 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:7318
Ube2bGeneProductENSRNOG00000059348 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:7320
Ube2d1GeneProductENSRNOG00000000611 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:7321
Ube2d2GeneProductENSRNOG00000042523 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:7322
Ube2d3GeneProductENSRNOG00000013741 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:7323
UbiquitinProteinNo homologues found for original id S:P0CG48
Uchl1GeneProductENSRNOG00000002343 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = En:ENSG00000154277
Uchl3GeneProductENSRNOG00000009530 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = En:ENSG00000118939

Annotated Interactions

No annotated interactions
Retrieved from "https://classic.wikipathways.org/index.php/Pathway:WP302"
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