G1 to S cell cycle control (Bos taurus)

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origin recognition complexpbpG1/S transition PhaseeCyclin DsG2 Phase-M phaseCheckpointG1 CyclinDependant CyclasesupinactiveRbDegradationupCell cycle DNA replication genesbcakDNA replicationppuDNA polymerasesdp1G1 PhaseG1/S transition CyclinDependent KinasesCyclin Esphosphorylation of proteinsinvolved in G1/S transitionE2fTTTCC/GCGCG1/S Cell CycleeCREB3CCNE2LOC615374ORC1LCCND2CDKN2DPOLE2MCM2CCNHCDK7E2fCREB3L4CdkCDKN2ACDKE2F6TP53CCNB1CCNE1LOC615374PCNAE2fCCNG2ORC2LE2F1POLECDK4CREB3L1CREB1RPA1CDKCDK4TFDP1CdkCCNE1PRIM1CDKN1CCDKN1APRIM2RB1E2F2CCND1CDKN2BMNAT1CDC45LGADD45ATFDP1RB1MCM6E2F3TP53MCM5ORC4LTFDP2ATMORC3LATF6BCyclinDMCM3RPA3MCM7ORC6LRBL1MCM4E2F4CDC25ACDK2CCNE1CDK6E2F5MYT1CREB3L3CDKN2CCDK6POLA2WEE1CyclinDCDK7MYCCCND3RB1RPA2ORC5LCCNA1MDM2CDKN1B


Description

No description

Comments

GenMAPP notes 
Adapted from http://www.genomeknowledge.org/, and Maeda et al. Journal of Invest Dermatol. 2002. 119:22-26.
HomologyConvert 
This pathway was inferred from Homo sapiens pathway WP45(r20771) with a 83% conversion rate.

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Quality Tags

Ontology Terms

 

Bibliography

  1. Maeda T, Hanna AN, Sim AB, Chua PP, Chong MT, Tron VA; ''GADD45 regulates G2/M arrest, DNA repair, and cell death in keratinocytes following ultraviolet exposure.''; J Invest Dermatol, 2002 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
95747view13:54, 19 January 2018MkutmonHomology conversion update
80826view15:27, 30 June 2015Mkutmonhomology conversion
67265view10:28, 26 June 2013Christine ChichesterOntology Term : 'G1/S DNA damage checkpoint pathway' added !
63326view21:07, 9 May 2013MaintBotUpdated to 2013 gpml schema
48129view05:48, 9 May 2012MaintBotUpdating from human to fix xref duplication
40507view19:28, 1 March 2011MaintBotRemoved redundant pathway information and comments
35825view21:59, 17 February 2010KhanspersAdded lit ref
35824view21:59, 17 February 2010KhanspersModified description
33750view23:58, 8 December 2009MaintBotAutomatic update of empty xrefs
32529view12:59, 17 August 2009MaintBotFixed text labels
32216view12:44, 15 August 2009MaintBotFixed text labels
31711view11:52, 14 August 2009MaintBotFixed group labels
31227view19:43, 13 August 2009MaintBotFixed text labels
30647view22:32, 29 July 2009MaintBotNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
ATF6BGeneProduct513928 (Entrez Gene)
ATMGeneProduct526824 (Entrez Gene)
CCNA1GeneProduct521939 (Entrez Gene)
CCNB1GeneProduct327679 (Entrez Gene)
CCND1GeneProduct524530 (Entrez Gene)
CCND2GeneProduct615414 (Entrez Gene)
CCND3GeneProduct540547 (Entrez Gene)
CCNE1GeneProduct533526 (Entrez Gene)
CCNE2GeneProduct538436 (Entrez Gene)
CCNG2GeneProduct512960 (Entrez Gene)
CCNHGeneProduct615512 (Entrez Gene)
CDC25AGeneProduct520188 (Entrez Gene)
CDC45LGeneProduct507122 (Entrez Gene)
CDKGeneProduct
CDK2GeneProduct519217 (Entrez Gene)
CDK4GeneProduct510618 (Entrez Gene)
CDK6GeneProduct511754 (Entrez Gene)
CDK7GeneProduct515462 (Entrez Gene)
CDKN1AGeneProduct513497 (Entrez Gene)
CDKN1BGeneProduct512613 (Entrez Gene)
CDKN1CGeneProduct510972 (Entrez Gene)
CDKN2AGeneProduct
CDKN2BGeneProduct527124 (Entrez Gene)
CDKN2CGeneProduct505691 (Entrez Gene)
CDKN2DGeneProduct510244 (Entrez Gene)
CREB1GeneProduct281713 (Entrez Gene)
CREB3GeneProduct281715 (Entrez Gene)
CREB3L1GeneProduct513105 (Entrez Gene)
CREB3L3GeneProduct513010 (Entrez Gene)
CREB3L4GeneProduct529566 (Entrez Gene)
CdkGeneProduct
CyclinDGeneProduct
E2F1GeneProduct535369 (Entrez Gene)
E2F2GeneProduct617024 (Entrez Gene)
E2F3GeneProduct541184 (Entrez Gene)
E2F4GeneProduct525428 (Entrez Gene)
E2F5GeneProduct
E2F6GeneProduct514085 (Entrez Gene)
E2fGeneProduct
GADD45AGeneProduct505463 (Entrez Gene)
LOC615374GeneProduct615374 (Entrez Gene)
MCM2GeneProduct510120 (Entrez Gene)
MCM3GeneProduct281302 (Entrez Gene)
MCM4GeneProduct504367 (Entrez Gene)
MCM5GeneProduct506970 (Entrez Gene)
MCM6GeneProduct517812 (Entrez Gene)
MCM7GeneProduct539924 (Entrez Gene)
MDM2GeneProduct540378 (Entrez Gene)
MNAT1GeneProduct534176 (Entrez Gene)
MYCGeneProduct511077 (Entrez Gene)
MYT1GeneProduct505552 (Entrez Gene)
ORC1LGeneProduct513523 (Entrez Gene)
ORC2LGeneProduct511281 (Entrez Gene)
ORC3LGeneProduct523714 (Entrez Gene)
ORC4LGeneProduct529245 (Entrez Gene)
ORC5LGeneProduct519409 (Entrez Gene)
ORC6LGeneProduct515476 (Entrez Gene)
PCNAGeneProduct515499 (Entrez Gene)
POLA2GeneProduct514793 (Entrez Gene)
POLEGeneProduct
POLE2GeneProduct518653 (Entrez Gene)
PRIM1GeneProduct506240 (Entrez Gene)
PRIM2GeneProduct514682 (Entrez Gene)
RB1GeneProduct534712 (Entrez Gene)
RBL1GeneProduct524870 (Entrez Gene)
RPA1GeneProduct504844 (Entrez Gene)
RPA2GeneProduct
RPA3GeneProduct512754 (Entrez Gene)
TFDP1GeneProduct534579 (Entrez Gene)
TFDP2GeneProduct
TP53GeneProduct281542 (Entrez Gene)
WEE1GeneProduct

Annotated Interactions

No annotated interactions
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