Wnt signaling pathway (Canis familiaris)

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NU->CYProteolytic cleavageControlDNucleusDCytoplasmDeacetylationLigandCY->NUGOCY->PMNUDReceptorGlycosylationPhosphorylationGene SymbolCY->NUPlasma membraneECPM->CYTranslocationActivationReaction through unknowm mechanisms/moleculesEndoplasmic reticulumDMolecule in the pathwayProteins in a complex interactionPalmitoylationPMUbiquitinationDCY->PMInhibitionGolgi apparatusAccession Number: NetPath_8; cellmap:8CY->PMAutophosphorylationDesumoylationMethylation(Protein-protein interaction)MitochondrionENCY->NUERDDEndosomeAcetylationSumoylationMTDDeubiquitinationCY->NUExtracellularCY->NUComplex formationEnzyme ComplexDephosphorylationMolecular AssociationDemethylationRecruitmentCY->PMDCYMAPK8IP1ANKRD6TFAP2AFZD1RUVBL1WNT4FZD2CTBP1AXIN1WNT2DAB2EP300FHL2LOC482772CSNK2A1JUNFZD5CSNK2A2WNT4SMAD3LEF1DAAM1BTRCMAP3K7MAPK1FZD7SMAD4PIN1MAPK9FRAT1CDC25CCSNK1DCSNK1ECSNK2BMAPK3DLG4WNT3AUBL1JUPWNT1WNT2AXIN1GSK3BMAPK8CXXC4SUMO2PRKCGARRB2SFRP2DLG1ARRB1CTNNB1CCND1CAMK2BCTNNB1DLG2RUNX2NKD1LRP6SKP1SALL1CRYBB2CUL1MARK2CDC2TCF3APCCTNNBIP1LRP5SENP2RAC1DVL3PAX2FZD8CDC2WNT3PRKCACSNK1A1APCGSK3BFZD9DVL2CDH1WNT1TCF4CSNK2A2LRP6FZD4TBPFZD1APCFZD6SOX1APCCAMK2AWNT1NR5A1MAGI3AXIN2ARRB2CTNNB1BTRCROR2MAP3K7CAMK2GVANGL2WNT1DVL1NLKDVL1DKK1DVL2AXIN1APCPIAS4FZD4SOX9DVL1TAX1BP3PRKCBCSNK2A1PPP2CARAF1WNT5AAKT1MAP1BSFRP1WNT3AWNT1AKT1WNT7ABRD7CTBP2LEF1FZD1RHOABCL9CAMK2DLRP1FRAT2FZD1MYB


Description

No description

Comments

GenMAPP notes 
NetPath_8; cellmap:8 - Wnt Signaling Pathway. This cancer signaling pathway is available at Cancer Cell Map (http://cancer.cellmap.org) and NetPath (http://www.netpath.org) and is part of a collaborative project between the Computational Biology Center at Memorial Sloan-Kettering Cancer Center (http://cbio.mskcc.org), PandeyLab at Johns Hopkins University (http://pandeylab.igm.jhmi.edu) and Institute of Bioinformatics (http://www.ibioinformatics.org). If you use this pathway, you must cite the Cancer Cell Map and NetPath websites until the pathway is published.
GenMAPP remarks 
http://cancer.cellmap.org, http://www.netpath.org
HomologyConvert 
This pathway was inferred from Homo sapiens pathway WP363(r28127) with a 88% conversion rate.

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Bibliography

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History

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CompareRevisionActionTimeUserComment
120586view19:06, 17 December 2021EweitzModified title
118794view04:45, 2 June 2021EgonwModified description
117979view11:20, 23 May 2021EweitzModified title
86975view14:29, 15 July 2016MkutmonOntology Term : 'Wnt signaling pathway' added !
79431view23:50, 21 March 2015KhanspersModified title
68504view21:48, 5 July 2013MaintBotUpdated to 2013 gpml schema
40655view21:48, 1 March 2011MaintBotRemoved redundant pathway information and comments
38720view19:34, 23 September 2010AlexanderPico
35033view09:18, 11 February 2010Thomasremoved old genmapp comments (moved to description)
35025view09:14, 11 February 2010ThomasModified description
33947view18:19, 9 December 2009MaintBotAutomatic update of empty xrefs
32544view13:04, 17 August 2009MaintBotFixed text labels
31242view19:48, 13 August 2009MaintBotFixed text labels
30667view22:39, 29 July 2009MaintBotNew pathway

External references

DataNodes

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NameTypeDatabase referenceComment
AKT1GeneProduct490878 (Entrez Gene)
ANKRD6GeneProduct481919 (Entrez Gene)
APCGeneProduct479139 (Entrez Gene)
ARRB1GeneProduct485189 (Entrez Gene)
ARRB2GeneProduct
AXIN1GeneProduct490099 (Entrez Gene)
AXIN2GeneProduct490903 (Entrez Gene)
BCL9GeneProduct483154 (Entrez Gene)
BRD7GeneProduct478130 (Entrez Gene)
BTRCGeneProduct486851 (Entrez Gene)
CAMK2AGeneProduct612941 (Entrez Gene)
CAMK2BGeneProduct
CAMK2DGeneProduct610764 (Entrez Gene)
CAMK2GGeneProduct489050 (Entrez Gene)
CCND1GeneProduct449028 (Entrez Gene)
CDC2GeneProduct488997 (Entrez Gene)
CDC25CGeneProduct610456 (Entrez Gene)
CDH1GeneProduct442858 (Entrez Gene)
CRYBB2GeneProduct
CSNK1A1GeneProduct479331 (Entrez Gene)
CSNK1DGeneProduct475928 (Entrez Gene)
CSNK1EGeneProduct474510 (Entrez Gene)
CSNK2A1GeneProduct477185 (Entrez Gene)
CSNK2A2GeneProduct478108 (Entrez Gene)
CSNK2BGeneProduct474844 (Entrez Gene)
CTBP1GeneProduct612240 (Entrez Gene)
CTBP2GeneProduct
CTNNB1GeneProduct477032 (Entrez Gene)
CTNNBIP1GeneProduct608589 (Entrez Gene)
CUL1GeneProduct475512 (Entrez Gene)
CXXC4GeneProduct610189 (Entrez Gene)
DAAM1GeneProduct490714 (Entrez Gene)
DAB2GeneProduct479353 (Entrez Gene)
DKK1GeneProduct
DLG1GeneProduct488036 (Entrez Gene)
DLG2GeneProduct485158 (Entrez Gene)
DLG4GeneProduct489462 (Entrez Gene)
DVL1GeneProduct489593 (Entrez Gene)
DVL2GeneProduct489464 (Entrez Gene)
DVL3GeneProduct478650 (Entrez Gene)
EP300GeneProduct
FHL2GeneProduct474544 (Entrez Gene)
FRAT1GeneProduct
FRAT2GeneProduct
FZD1GeneProduct482294 (Entrez Gene)
FZD2GeneProduct490937 (Entrez Gene)
FZD4GeneProduct485149 (Entrez Gene)
FZD5GeneProduct488493 (Entrez Gene)
FZD6GeneProduct403610 (Entrez Gene)
FZD7GeneProduct488478 (Entrez Gene)
FZD8GeneProduct
FZD9GeneProduct489809 (Entrez Gene)
GSK3BGeneProduct478575 (Entrez Gene)
JUNGeneProduct609429 (Entrez Gene)
JUPGeneProduct480522 (Entrez Gene)
LEF1GeneProduct478507 (Entrez Gene)
LOC482772GeneProduct482772 (Entrez Gene)
LRP1GeneProduct481124 (Entrez Gene)
LRP5GeneProduct
LRP6GeneProduct477692 (Entrez Gene)
MAGI3GeneProduct483214 (Entrez Gene)
MAP1BGeneProduct478092 (Entrez Gene)
MAP3K7GeneProduct
MAPK1GeneProduct477575 (Entrez Gene)
MAPK3GeneProduct486758 (Entrez Gene)
MAPK8GeneProduct477746 (Entrez Gene)
MAPK8IP1GeneProduct483640 (Entrez Gene)
MAPK9GeneProduct474652 (Entrez Gene)
MARK2GeneProduct483769 (Entrez Gene)
MYBGeneProduct483995 (Entrez Gene)
NKD1GeneProduct487288 (Entrez Gene)
NLKGeneProduct491160 (Entrez Gene)
NR5A1GeneProduct609642 (Entrez Gene)
PAX2GeneProduct609228 (Entrez Gene)
PIAS4GeneProduct485049 (Entrez Gene)
PIN1GeneProduct484963 (Entrez Gene)
PPP2CAGeneProduct403608 (Entrez Gene)
PRKCAGeneProduct490904 (Entrez Gene)
PRKCBGeneProduct489968 (Entrez Gene)
PRKCGGeneProduct484316 (Entrez Gene)
RAC1GeneProduct403955 (Entrez Gene)
RAF1GeneProduct484648 (Entrez Gene)
RHOAGeneProduct403954 (Entrez Gene)
ROR2GeneProduct484193 (Entrez Gene)
RUNX2GeneProduct
RUVBL1GeneProduct476512 (Entrez Gene)
SALL1GeneProduct487284 (Entrez Gene)
SENP2GeneProduct478661 (Entrez Gene)
SFRP1GeneProduct
SFRP2GeneProduct475471 (Entrez Gene)
SKP1GeneProduct474682 (Entrez Gene)
SMAD3GeneProduct610902 (Entrez Gene)
SMAD4GeneProduct476196 (Entrez Gene)
SOX1GeneProduct607464 (Entrez Gene)
SOX9GeneProduct403464 (Entrez Gene)
SUMO2GeneProduct474963 (Entrez Gene)
TAX1BP3GeneProduct491221 (Entrez Gene)
TBPGeneProduct611193 (Entrez Gene)
TCF3GeneProduct485079 (Entrez Gene)
TCF4GeneProduct403949 (Entrez Gene)
TFAP2AGeneProduct488213 (Entrez Gene)
UBL1GeneProduct
VANGL2GeneProduct
WNT1GeneProduct486560 (Entrez Gene)
WNT2GeneProduct612141 (Entrez Gene)
WNT3GeneProduct609107 (Entrez Gene)
WNT3AGeneProduct482208 (Entrez Gene)
WNT4GeneProduct612367 (Entrez Gene)
WNT5AGeneProduct484721 (Entrez Gene)
WNT7AGeneProduct607180 (Entrez Gene)

Annotated Interactions

No annotated interactions
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