NOD pathway (Homo sapiens)

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Muramyl Dipeptidee.g. Bacillus anthracis CleavesInflammasomeActivated by Flagellin from L. pneumophila,S. typhimurium, Shigella flexneri, or P. aeruginosadownregulatesMuramyl Dipeptide &ATP induce Oligomerization cleavesUpregulatesNigericin, Maitotoxin, Aerolysin(pore forming toxins)Asbestos, Silica Gram +ve L. monocytogenesS. aureus, M. marinum ATPcleavescleavesPeptidoglycan CARD9CARD6NLRP1XIAPAAMPCASP5NFKBIASUGT1CASP9MEFVIKBKGNLRP12NLRP3NOD1PRDM1PYCARDNDUFA13CARD8NLRC4RIPK2NOD2CENTB1CASP1RAC1NLRP2NLRP10COPS6NAIPIL18NLRP7DUOX2CASP8NLRP4HSP90AA2IL1BRELACHUKIKBKB


Description

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Bibliography


History

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CompareRevisionActionTimeUserComment
33715view19:58, 7 December 2009MaintBotDeleted pathway: Duplicate: http://www.wikipathways.org/index.php/Pathway:WP1433
33005view23:39, 30 September 2009MisbahPeriodical save, work in progress
33004view23:02, 30 September 2009MisbahPeriodical save, work in progress
33003view22:34, 30 September 2009MisbahUPDATES
33002view22:30, 30 September 2009MisbahPeriodical save, work in progress
33001view21:40, 30 September 2009MisbahPeriodical save, work in progress
33000view21:04, 30 September 2009MisbahPeriodical save, work in progress
32999view19:34, 30 September 2009MisbahPeriodical save, work in progress
32998view19:24, 30 September 2009MisbahPeriodical save, work in progress
32994view19:00, 30 September 2009MisbahPeriodical save, work in progress
32991view18:43, 30 September 2009MisbahPeriodical save, work in progress
32989view18:33, 30 September 2009MisbahPeriodical save, work in progress
32987view17:48, 30 September 2009MisbahNew pathway

External references

DataNodes

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NameTypeDatabase referenceComment
AAMPGeneProductENSG00000127837 (Ensembl Human)
CARD6GeneProductENSG00000132357 (Ensembl Human)
CARD8GeneProductENSG00000105483 (Ensembl Human)
CARD9GeneProductENSG00000187796 (Ensembl Human)
CASP1GeneProductENSG00000137752 (Ensembl Human)
CASP5GeneProductENSG00000137757 (Ensembl Human)
CASP8GeneProductENSG00000064012 (Ensembl Human)
CASP9GeneProductENSG00000132906 (Ensembl Human)
CENTB1GeneProductENSG00000072818 (Ensembl Human)
CHUKGeneProductENSG00000213341 (Ensembl Human)
COPS6GeneProductENSG00000168090 (Ensembl Human)
DUOX2GeneProductENSG00000140279 (Ensembl Human)
HSP90AA2GeneProductENSG00000080824 (Ensembl Human)
IKBKBGeneProductENSG00000104365 (Ensembl Human)
IKBKGGeneProductENSG00000073009 (Ensembl Human)
IL18GeneProductENSG00000150782 (Ensembl Human)
IL1BGeneProductENSG00000125538 (Ensembl Human)
MEFVGeneProductENSG00000103313 (Ensembl Human)
NAIPGeneProductENSG00000081770 (Ensembl Human)
NDUFA13GeneProductENSG00000130288 (Ensembl Human)
NFKBIAGeneProductENSG00000100906 (Ensembl Human)
NLRC4GeneProductENSG00000091106 (Ensembl Human)
NLRP10GeneProductENSG00000182261 (Ensembl Human)
NLRP12GeneProductENSG00000142405 (Ensembl Human)
NLRP1GeneProductENSG00000091592 (Ensembl Human)
NLRP2GeneProductENSG00000022556 (Ensembl Human)
NLRP3GeneProductENSG00000162711 (Ensembl Human)
NLRP4GeneProductENSG00000160505 (Ensembl Human)
NLRP7GeneProductENSG00000167634 (Ensembl Human)
NOD1GeneProductENSG00000106100 (Ensembl Human)
NOD2GeneProductENSG00000167207 (Ensembl Human)
PRDM1GeneProductENSG00000057657 (Ensembl Human)
PYCARDGeneProductENSG00000103490 (Ensembl Human)
RAC1GeneProductENSG00000136238 (Ensembl Human)
RELAGeneProductENSG00000173039 (Ensembl Human)
RIPK2GeneProductENSG00000104312 (Ensembl Human)
SUGT1GeneProductENSG00000165416 (Ensembl Human)
XIAPGeneProductENSG00000101966 (Ensembl Human)

Annotated Interactions

No annotated interactions

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