DNA replication (Gallus gallus)

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Orc2Orc3Phosphorylation ofMcm 2-7 complexRFC40Mcm10Orc complexMcm75. Leading/lagging strand synthesisRFC Heteropentamer:RNA primer-DNA primerPCNA homotrimerp70Ubiquitinated Cdc6Orc5Processive complexOrc complexRNA primer-DNA primerDNA polymerase alpha:primase: origin complexRFC38RFC Heteropentamer:RNA primer-DNA primer1. Assembly of the pre-replicative complexMcm6DNAPolymerase ARNA primer-DNA primerOrc4UbiquitinOrc3Orc2UbiquitinMcm7Mcm3p180Orc1Phosphorylated Orc1Mcm 4,6,7 trimer forms andassociates with the replication forkRFC36Cdt1Mcm4Mcm5Cdc6Mcm3Cdc6Orc5Mcm5Orc complexOrc2RFC1403. DNA replication initiationOrc3Cdt12. Activation of the pre-replicative complexPre-replicative complexMcm2Orc complexp49RNA primer-DNA primer:origin duplex:PCNAOrc2Cdc6PrimaseOriginp58Degraded by proteasome in cytosolOrc3Pre-replicative complexOrc4GemininCdc6RFC37Cdt1Mcm2RNA PrimerOrc complexCdt1Orc5Mcm6DNA polymerase alpha:primase: origin complexMcm10Phosphorylated Cdc6Degraded byproteasomein cytosol4. Switching of origins to post-replicative stateMcm4Cdt1Ubiquitinated Orc1POLEATPRFC2UTPCDK2ATPDBF4RPA4MCM5GMNNCDC45LRFC1ORC6LGTPADPRPA1UBA52ORC5LMCM4CDC6dATPPOLD4ORC2LMCM10dGTPPOLD1RFC4PCNAPRIM2PRIM1dCTPdUTPRFC3ATPMCM2ATPRFC5MCM6ORC4LPOLD2CDC7POLE2CDT1ORC1LRCJMB04_6d17POLA2ORC3LRPA3POLD3POLA1ADPMCM3UBCCTPMCM7


Description

No description

Comments

GenMAPP notes 
http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=69306
GenMAPP remarks 
Based on www.reactome.org
HomologyConvert 
This pathway was inferred from Homo sapiens pathway WP466(r21660) with a 54% conversion rate.

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Quality Tags

Ontology Terms

 

Bibliography

  1. Bell SP, Dutta A; ''DNA replication in eukaryotic cells.''; Annu Rev Biochem, 2002 PubMed Europe PMC Scholia
  2. Kelly TJ, Brown GW; ''Regulation of chromosome replication.''; Annu Rev Biochem, 2000 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
117195view10:32, 18 May 2021EweitzModified title
68859view17:20, 8 July 2013MaintBotUpdated to 2013 gpml schema
68762view15:29, 7 July 2013EgonwRemoved data source where no ID was given.
67165view10:15, 26 June 2013Christine ChichesterOntology Term : 'DNA replication pathway' added !
40997view22:56, 1 March 2011MaintBotRemoved redundant pathway information and comments
35218view15:49, 11 February 2010Thomasadded literature
35210view15:44, 11 February 2010ThomasModified description
35204view15:41, 11 February 2010ThomasModified description
33918view18:06, 9 December 2009MaintBotAutomatic update of empty xrefs
33442view14:58, 30 November 2009MaintBotRemoved group label
31499view21:32, 13 August 2009MaintBotFixed text labels
30326view20:45, 29 July 2009MaintBotNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
ADPGeneProduct
ATPGeneProduct
CDC45LGeneProduct416776 (Entrez Gene)
CDC6GeneProduct
CDC7GeneProduct424507 (Entrez Gene)
CDK2GeneProduct
CDT1GeneProduct
CTPGeneProduct
DBF4GeneProduct420536 (Entrez Gene)
GMNNGeneProduct421004 (Entrez Gene)
GTPGeneProduct
MCM10GeneProduct
MCM2GeneProduct416027 (Entrez Gene)
MCM3GeneProduct422043 (Entrez Gene)
MCM4GeneProduct426764 (Entrez Gene)
MCM5GeneProduct418058 (Entrez Gene)
MCM6GeneProduct424295 (Entrez Gene)
MCM7GeneProduct
ORC1LGeneProduct424640 (Entrez Gene)
ORC2LGeneProduct424077 (Entrez Gene)
ORC3LGeneProduct421822 (Entrez Gene)
ORC4LGeneProduct424307 (Entrez Gene)
ORC5LGeneProduct417714 (Entrez Gene)
ORC6LGeneProduct415749 (Entrez Gene)
PCNAGeneProduct373984 (Entrez Gene)
POLA1GeneProduct418593 (Entrez Gene)
POLA2GeneProduct
POLD1GeneProduct
POLD2GeneProduct
POLD3GeneProduct419053 (Entrez Gene)
POLD4GeneProduct
POLE2GeneProduct423567 (Entrez Gene)
POLEGeneProduct416997 (Entrez Gene)
PRIM1GeneProduct426646 (Entrez Gene)
PRIM2GeneProduct421878 (Entrez Gene)
RCJMB04_6d17GeneProduct419566 (Entrez Gene)
RFC1GeneProduct422788 (Entrez Gene)
RFC2GeneProduct396542 (Entrez Gene)
RFC3GeneProduct418907 (Entrez Gene)
RFC4GeneProduct424958 (Entrez Gene)
RFC5GeneProduct
RPA1GeneProduct417563 (Entrez Gene)
RPA3GeneProduct420578 (Entrez Gene)
RPA4GeneProduct
UBA52GeneProduct
UBCGeneProduct396425 (Entrez Gene)
UTPGeneProduct
dATPGeneProduct
dCTPGeneProduct
dGTPGeneProduct
dUTPGeneProduct

Annotated Interactions

No annotated interactions
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