Eukaryotic transcription initiation (Gallus gallus)
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(small stable RNAs)
Steps 2) Association of TIFs and RNA polymerase
5
TFIIH
Steps 5) RNA elongation with CDT phosphorylation
RNA polymerase II
TFIIB
TFIIE
Steps 3) DNA melting by association with TFIIH
Transcription Initiation Factors (TIFs)
TFIIF
(recognize surface DNA geometry)
TFIIH
Gene Regulatory Proteins
RNA pol II
3
5
TATA Box binding
protein
Steps 4) Transcription elongation by NTPs
(large ribosomal RNAs)
RNA polymerase I
Steps 1) TBP binds TATA box
TATA
3
dsDNA
TFIIE
TFIID
5
TFIID
TFIIA
RNA polymerase III
TFIIA
3
3
TATA
TFIIB
5
3
TATA
5
5
5
5
3
3
cell growth
Primary RNA transcript
5
5
3
(mRNA, snRNPs)
TFIIF
TFIIF
3
POLR2K
TPTE
POLR2J
GTF2H3
TAF7
GTF2E1
ILK
TAF6
CCNH
POLR1D
GTF2F2
POLR1B
POLR3E
GTF2H1
GTF2E2
GTF2B
ERCC3
POLR3B
TAF9
MNAT1
POLR3D
RCJMB04_15p4
TAF12
POLR2C
POLR2I
CDK7
POLR3K
GTF2H2
TBP
POLR2E
POLR2A
POLR1A
POLR2G
POLR2F
POLR2B
GTF2A2
POLR2H
ERCC2
POLR3H
TAF13
GTF2H4
Description
No description
Comments
GenMAPP notes
Reference:
http://www.web-books.com/MoBio/Free/Ch4E.htm
GenMAPP remarks
right click for notes & references
HomologyConvert
This pathway was inferred from Homo sapiens pathway
WP405(r29565)
with a 80% conversion rate.
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Quality Tags
Ontology Terms
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Bibliography
Lee TI, Young RA; ''Regulation of gene expression by TBP-associated proteins.''; Genes Dev, 1998
PubMed
Europe PMC
Scholia
Lemon B, Tjian R; ''Orchestrated response: a symphony of transcription factors for gene control.''; Genes Dev, 2000
PubMed
Europe PMC
Scholia
History
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Compare
Revision
Action
Time
User
Comment
118407
view
14:14, 27 May 2021
Eweitz
Ontology Term : 'RNA polymerase III transcription initiation pathway' added !
118393
view
13:59, 27 May 2021
Eweitz
Ontology Term : 'PW:0001575' removed !
118392
view
13:59, 27 May 2021
Eweitz
Ontology Term : 'PW:0001274' removed !
118391
view
13:59, 27 May 2021
Eweitz
Ontology Term : 'PW:0001570' removed !
118390
view
13:58, 27 May 2021
Eweitz
Ontology Term : 'RNA polymerase III transcription initiation pathway' added !
118389
view
13:58, 27 May 2021
Eweitz
Ontology Term : 'RNA polymerase I transcription initiation pathway' added !
118388
view
13:58, 27 May 2021
Eweitz
Ontology Term : 'RNA polymerase II transcription initiation pathway' added !
118386
view
13:57, 27 May 2021
Eweitz
Ontology Term : 'PW:0000100' removed !
118385
view
13:57, 27 May 2021
Eweitz
Ontology Term : 'RNA polymerase I transcription initiation pathway' added !
118384
view
13:56, 27 May 2021
Eweitz
Ontology Term : 'RNA polymerase III transcription initiation pathway' added !
118381
view
13:55, 27 May 2021
Eweitz
Ontology Term : 'RNA polymerase II transcription initiation pathway' added !
117194
view
10:32, 18 May 2021
Eweitz
Modified title
68790
view
17:13, 8 July 2013
MaintBot
Updated to 2013 gpml schema
67217
view
10:22, 26 June 2013
Christine Chichester
Ontology Term : 'transcription pathway' added !
58767
view
22:15, 20 February 2013
MaintBot
Updated Ensembl and UniProt data source
47789
view
16:25, 6 April 2012
Khanspers
updated xref
40921
view
22:51, 1 March 2011
MaintBot
Removed redundant pathway information and comments
35527
view
13:57, 12 February 2010
Thomas
added literature
35515
view
13:51, 12 February 2010
Thomas
Modified description
33852
view
17:42, 9 December 2009
MaintBot
Automatic update of empty xrefs
33500
view
15:13, 30 November 2009
MaintBot
Removed group label
31547
view
21:51, 13 August 2009
MaintBot
Fixed text labels
30399
view
21:09, 29 July 2009
MaintBot
New pathway
External references
DataNodes
View all...
Name
Type
Database reference
Comment
CCNH
GeneProduct
427328 (Entrez Gene)
CDK7
GeneProduct
ERCC2
GeneProduct
ERCC3
GeneProduct
424226 (Entrez Gene)
GTF2A2
GeneProduct
770910 (Entrez Gene)
GTF2B
GeneProduct
424518 (Entrez Gene)
GTF2E1
GeneProduct
418328 (Entrez Gene)
GTF2E2
GeneProduct
771227 (Entrez Gene)
GTF2F2
GeneProduct
418843 (Entrez Gene)
GTF2H1
GeneProduct
423081 (Entrez Gene)
GTF2H2
GeneProduct
GTF2H3
GeneProduct
771837 (Entrez Gene)
GTF2H4
GeneProduct
ILK
GeneProduct
374018 (Entrez Gene)
MNAT1
GeneProduct
423521 (Entrez Gene)
POLR1A
GeneProduct
422910 (Entrez Gene)
POLR1B
GeneProduct
416710 (Entrez Gene)
POLR1D
GeneProduct
428713 (Entrez Gene)
POLR2A
GeneProduct
POLR2B
GeneProduct
422621 (Entrez Gene)
POLR2C
GeneProduct
415635 (Entrez Gene)
POLR2E
GeneProduct
420103 (Entrez Gene)
POLR2F
GeneProduct
395486 (Entrez Gene)
POLR2G
GeneProduct
POLR2H
GeneProduct
424954 (Entrez Gene)
POLR2I
GeneProduct
426289 (Entrez Gene)
POLR2J
GeneProduct
POLR2K
GeneProduct
768387 (Entrez Gene)
POLR3B
GeneProduct
418071 (Entrez Gene)
POLR3D
GeneProduct
POLR3E
GeneProduct
416620 (Entrez Gene)
POLR3H
GeneProduct
417990 (Entrez Gene)
POLR3K
GeneProduct
768505 (Entrez Gene)
RCJMB04_15p4
GeneProduct
423872 (Entrez Gene)
TAF12
GeneProduct
419585 (Entrez Gene)
TAF13
GeneProduct
418365 (Entrez Gene)
TAF6
GeneProduct
776310 (Entrez Gene)
TAF7
GeneProduct
422192 (Entrez Gene)
TAF9
GeneProduct
422152 (Entrez Gene)
TBP
GeneProduct
395995 (Entrez Gene)
TPTE
GeneProduct
418885 (Entrez Gene)
Annotated Interactions
No annotated interactions
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