FAS pathway and stress induction of HSP regulation (Pan troglodytes)
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DNA presentation
Cytoplasm
Stress Induction of HSP regulation
NFK-B Pathway
3x-P
Mitochondria Pathway
Self-activation
Stress
Nucleus
FAS Pathway
Apoptosis
Necrosis
Activate
Extracellular
ROS
Apoptosome
Cell Survival
Proteasome
3x-P
Cut
3x-P
Inhibition
Ceramide
RIPK2
CASP3
MAP3K1
Phosphate
CASP9
Glutathione
actin
FADD
Phosphate
Phosphate
APAF1
BCL2
MAPKAPK3
Phosphate
IL1A
SPTAN1
DAXX
HSPB1
DFFB
DAXX
MAP3K7
HSPB1
MAPK8
APAF1
HSPB1
HSPB1
DFFB
DFFA
CYCS
CASP7
Phosphate
TNF
HSPB1
JUN
HSPB1
Phosphate
CASP8
LMNB1
PARP1
Phosphate
ARHGDIB
CASP10
FAF1
FAS
CFLAR
PAK1
LMNB2
LMNA
CASP3
MAPKAPK2
CASP6
Phosphate
RB1
HSPB1
PRKDC
RHOXF2
CASP8
MAP2K4
HSPB1
FASLG
FAF1
PAK2
Description
No description
Comments
GenMAPP remarks
Converted to human by GenMAPP.org.
HomologyConvert
This pathway was inferred from Homo sapiens pathway
WP314(r21341)
with a 87% conversion rate.
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Quality Tags
Ontology Terms
Saving...
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Bibliography
Creagh EM, Sheehan D, Cotter TG; ''Heat shock proteins--modulators of apoptosis in tumour cells.''; Leukemia, 2000
PubMed
Europe PMC
Scholia
History
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Compare
Revision
Action
Time
User
Comment
117066
view
14:25, 16 May 2021
Eweitz
Modified title
111163
view
09:26, 21 July 2020
Egonw
Made another pathway clickable
106930
view
13:39, 17 September 2019
MaintBot
HMDB identifier normalization
69227
view
18:33, 8 July 2013
MaintBot
Updated to 2013 gpml schema
67226
view
10:23, 26 June 2013
Christine Chichester
Ontology Term : 'FasL mediated signaling pathway' added !
48165
view
20:24, 9 May 2012
MaintBot
Updating from human to fix xref
41530
view
01:57, 2 March 2011
MaintBot
Removed redundant pathway information and comments
38246
view
21:24, 27 August 2010
Khanspers
Removed receptor and protein complex graphics
35557
view
15:00, 12 February 2010
Thomas
Modified description
35554
view
14:58, 12 February 2010
Thomas
added literature
34266
view
21:52, 9 December 2009
MaintBot
Automatic update of empty xrefs
33562
view
09:44, 1 December 2009
MaintBot
Removed group label
31589
view
22:04, 13 August 2009
MaintBot
Fixed text labels
30471
view
21:32, 29 July 2009
MaintBot
New pathway
External references
DataNodes
View all...
Name
Type
Database reference
Comment
APAF1
GeneProduct
452153 (Entrez Gene)
ARHGDIB
GeneProduct
742002 (Entrez Gene)
Interim Symbol: Arhgdib predicted and Name: Rho, GDP dissociation inhibitor (GDI) beta (predicted)
BCL2
GeneProduct
738409 (Entrez Gene)
CASP10
GeneProduct
CASP3
GeneProduct
461669 (Entrez Gene)
CASP6
GeneProduct
736606 (Entrez Gene)
CASP7
GeneProduct
450745 (Entrez Gene)
CASP8
GeneProduct
746477 (Entrez Gene)
CASP9
GeneProduct
456457 (Entrez Gene)
CFLAR
GeneProduct
459872 (Entrez Gene)
CYCS
GeneProduct
Ceramide
GeneProduct
DAXX
GeneProduct
462613 (Entrez Gene)
DFFA
GeneProduct
457928 (Entrez Gene)
DFFB
GeneProduct
744932 (Entrez Gene)
FADD
GeneProduct
451389 (Entrez Gene)
FAF1
GeneProduct
456846 (Entrez Gene)
FAS
GeneProduct
738331 (Entrez Gene)
FASLG
GeneProduct
469584 (Entrez Gene)
Glutathione
Metabolite
HMDB00125 (HMDB)
HSPB1
GeneProduct
463488 (Entrez Gene)
IL1A
GeneProduct
470485 (Entrez Gene)
JUN
GeneProduct
456893 (Entrez Gene)
LMNA
GeneProduct
457385 (Entrez Gene)
LMNB1
GeneProduct
462035 (Entrez Gene)
LMNB2
GeneProduct
468657 (Entrez Gene)
MAP2K4
GeneProduct
455065 (Entrez Gene)
MAP3K1
GeneProduct
MAP3K7
GeneProduct
462888 (Entrez Gene)
MAPK8
GeneProduct
450445 (Entrez Gene)
MAPKAPK2
GeneProduct
744091 (Entrez Gene)
MAPKAPK3
GeneProduct
460400 (Entrez Gene)
PAK1
GeneProduct
451439 (Entrez Gene)
PAK2
GeneProduct
460965 (Entrez Gene)
PARP1
GeneProduct
PRKDC
GeneProduct
464165 (Entrez Gene)
Phosphate
Metabolite
HMDB01429 (HMDB)
RB1
GeneProduct
452715 (Entrez Gene)
RHOXF2
GeneProduct
473763 (Entrez Gene)
RIPK2
GeneProduct
464277 (Entrez Gene)
receptor (TNFRSF)-interacting serine-threonine kinase 2
SPTAN1
GeneProduct
Interim Symbol: Spna1 predicted and Name: spectrin alpha 1 (predicted)
TNF
GeneProduct
744399 (Entrez Gene)
actin
GeneProduct
Annotated Interactions
No annotated interactions
Views
Pathway
Discussion
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DataNodes
Annotated Interactions
No annotated interactions