Proteasome Degradation (Pan troglodytes)

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Beta subunitsLid subunitsAlpha subunitsUnfolds and DegradesIntact Proteinsp45 ATPase SubunitOxidatively DamagedCytosolic ProteinsActivators of20S ComplexUbiquitin/ProteinDeubiquitinates proteinsE3/ProteinPresentation by MHC class 1Degrades only PeptidesProteasome 20SCatalytic Core (p45)Ubiquitin/E2 ComplexProteasome 26 S(PA700) (ATP dependent)Proteins to be DegradedAMP Ubiquitin/E1 ComplexPATR-BPSMB8PSMD8PSMD11PSMB5HIST1H2ABPSMB6UBA1UBE2BPSMB7PSMA7PATR-CPSME2PSMC5PSMC3PSMD13PSMB3PSMA2NEDD4PSMB4PSMD2UCHL3PATR-EPSMD7HLA-HPSMB9LOC461400PSMD6UBA7PSME1PSMC2PSMB1PSMD5UCHL1PSMD12RPN1HLA-JHLA-GPSMA5PSME3H2AFJPSMB10IFNGPSMA6PSMC6PSMD1PSMA3UBCUBBUBE2D3PPSMD9PSMD3PSMC4RPN2UBE2D1PSMD10UbiquitinUBE2D2PSMB2PSMD4PATR-APSMA4PSMA1HLA-FATPPSMC1PSMC5


Description

No description

Comments

HomologyConvert 
This pathway was inferred from Homo sapiens pathway WP183(r29614) with a 74% conversion rate.

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Quality Tags

Ontology Terms

 

Bibliography

No bibliography


History

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CompareRevisionActionTimeUserComment
87615view08:54, 25 July 2016LindarieswijkOntology Term : 'ubiquitin, ubiquitin-like/proteasome degradation pathway' added !
71664view19:40, 17 October 2013MaintBotAutomated update of data sources
69241view18:35, 8 July 2013MaintBotUpdated to 2013 gpml schema
62737view03:33, 2 May 2013MaintBotUpdated UniProt data source
58904view04:47, 21 February 2013MaintBotUpdated Ensembl and UniProt data source
41546view01:58, 2 March 2011MaintBotRemoved redundant pathway information and comments
34277view21:57, 9 December 2009MaintBotAutomatic update of empty xrefs
33609view09:59, 1 December 2009MaintBotRemoved group label
31623view22:19, 13 August 2009MaintBotFixed text labels
30529view21:52, 29 July 2009MaintBotNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
ATPGeneProduct
H2AFJGeneProduct465306 (Entrez Gene)
HIST1H2ABGeneProduct
HLA-FGeneProduct
HLA-GGeneProduct
HLA-HGeneProduct
HLA-JGeneProduct
IFNGGeneProduct449517 (Entrez Gene)
LOC461400GeneProduct461400 (Entrez Gene)
NEDD4GeneProduct467689 (Entrez Gene)
PATR-AGeneProduct450151 (Entrez Gene)
PATR-BGeneProduct450202 (Entrez Gene)
PATR-CGeneProduct471962 (Entrez Gene)
PATR-EGeneProduct462540 (Entrez Gene)
PSMA1GeneProduct451040 (Entrez Gene)
PSMA2GeneProduct472653 (Entrez Gene)
PSMA3GeneProduct467469 (Entrez Gene)
PSMA4GeneProduct453569 (Entrez Gene)
PSMA5GeneProduct
PSMA6GeneProduct452861 (Entrez Gene)
PSMA7GeneProduct458383 (Entrez Gene)
PSMB10GeneProduct
PSMB1GeneProduct473258 (Entrez Gene)
PSMB2GeneProduct469277 (Entrez Gene)
PSMB3GeneProduct
PSMB4GeneProduct457293 (Entrez Gene)
PSMB5GeneProduct
PSMB6GeneProduct454453 (Entrez Gene) U13393
PSMB7GeneProduct464723 (Entrez Gene)
PSMB8GeneProduct746418 (Entrez Gene)
PSMB9GeneProduct746436 (Entrez Gene)
PSMC1GeneProduct453097 (Entrez Gene)
PSMC2GeneProduct463632 (Entrez Gene)
PSMC3GeneProduct451172 (Entrez Gene)
PSMC4GeneProduct737578 (Entrez Gene) PRS6 HUMAN
PSMC5GeneProduct454777 (Entrez Gene) PRS6 HUMAN
PSMC6GeneProduct452909 (Entrez Gene)
PSMD10GeneProduct465803 (Entrez Gene)
PSMD11GeneProduct454574 (Entrez Gene)
PSMD12GeneProduct454836 (Entrez Gene)
PSMD13GeneProduct450913 (Entrez Gene)
PSMD1GeneProduct470674 (Entrez Gene)
PSMD2GeneProduct460887 (Entrez Gene)
PSMD3GeneProduct
PSMD4GeneProduct
PSMD5GeneProduct464699 (Entrez Gene)
PSMD6GeneProduct465457 (Entrez Gene)
PSMD7GeneProduct454240 (Entrez Gene)
PSMD8GeneProduct
PSMD9GeneProduct465187 (Entrez Gene)
PSME1GeneProduct452809 (Entrez Gene)
PSME2GeneProduct744802 (Entrez Gene)
PSME3GeneProduct
RPN1GeneProduct460673 (Entrez Gene)
RPN2GeneProduct458228 (Entrez Gene)
UBA1GeneProduct749307 (Entrez Gene)
UBA7GeneProduct744322 (Entrez Gene)
UBBGeneProduct
UBCGeneProduct
UBE2BGeneProduct462065 (Entrez Gene)
UBE2D1GeneProduct745141 (Entrez Gene)
UBE2D2GeneProduct462108 (Entrez Gene)
UBE2D3PGeneProduct745118 (Entrez Gene)
UCHL1GeneProductENSPTRG00000016009 (Ensembl Chimp)
UCHL3GeneProductENSPTRG00000005934 (Ensembl Chimp)
UbiquitinProtein

Annotated Interactions

No annotated interactions
Retrieved from "https://classic.wikipathways.org/index.php/Pathway:WP960"
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