Integrin-mediated cell adhesion (Pan troglodytes)
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PI3K
cell motility
cell maintenance
signaling system
ERK
cell maintenance
Phosphatidylinositiol
RAF
p130 Cas
Integrin alpha
MEK
ECM
ITGB
ITGA
PAK
CAPN
PAK
CAPN
cell proliferation
C3G
F-actin
Integrin beta
F-actin
MAPK1
BCAR1
CSK
RAC2
ITGA7
PI5K
ITGA11
TLN1
PXN
SHC3
ITGAM
BRAF
ITGAE
MAPK7
ACTN
PDPK1
MAPK4
PAK3
ARHGEF7
CAPN2
ITGAL
CAPNS1
GRB2
RAP1A
ITGB2
CAV1
SRC
RAC1
ITGB1
RAPGEF1
MYLK2
RAP1B
VASP
AKT2
CAPN11
ITGA8
CDC42
ITGA1
MAP2K5
PAK1
PTK2
SORBS1
ITGA10
HRAS
ITGB5
ROCK1
ARAF
RAF1
ITGAD
ITGA3
MAP2K3
MYO-P
SRC
PAK4
PTK2
ZYX
ITGAX
MAP2K1
ITGB8
ITGB6
ITGA6
ROCK2
VCL
PIK3R2
CAPN1
CAV3
DOCK1
AKT1
FYN
SHC1
SEPP1
CRK
CAPN7
GIT2
AKT3
MYO
PAK2
CAPN5
MAP2K6
PAK6
CAV2
VAV3
MAP2K2
VAV2
ITGB4
p110
ILK
ITGA9
RHO
ITGA2
ITGB7
MAPK12
CAPN6
ITGA2B
TNS1
SOS1
CAPN3
RAC3
CAPN9
ITGA5
ITGA4
ITGB3
MAPK6
CAPN10
ITGAV
MAPK10
Description
No description
Comments
HomologyConvert
This pathway was inferred from Homo sapiens pathway
WP185(r21067)
with a 70% conversion rate.
Try the New WikiPathways
View approved pathways at
the new wikipathways.org
.
Quality Tags
Ontology Terms
Saving...
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Bibliography
Sepulveda JL, Gkretsi V, Wu C; ''Assembly and signaling of adhesion complexes.''; Curr Top Dev Biol, 2005
PubMed
Europe PMC
Scholia
History
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Compare
Revision
Action
Time
User
Comment
71672
view
19:41, 17 October 2013
MaintBot
Automated update of data sources
69265
view
18:38, 8 July 2013
MaintBot
Updated to 2013 gpml schema
67405
view
10:57, 26 June 2013
Ddigles
Ontology Term : 'integrin mediated signaling pathway' added !
62740
view
03:34, 2 May 2013
MaintBot
Updated UniProt data source
41573
view
02:00, 2 March 2011
MaintBot
Removed redundant pathway information and comments
35602
view
15:46, 12 February 2010
Thomas
Modified description
35595
view
15:43, 12 February 2010
Thomas
added literature
34301
view
22:05, 9 December 2009
MaintBot
Automatic update of empty xrefs
33600
view
09:56, 1 December 2009
MaintBot
Removed group label
30520
view
21:49, 29 July 2009
MaintBot
New pathway
External references
DataNodes
View all...
Name
Type
Database reference
Comment
ACTN
GeneProduct
AKT1
GeneProduct
740898 (Entrez Gene)
AKT1; v-akt murine thymoma viral oncogene homolog 1 [EC:2.7.1.-]
AKT2
GeneProduct
456035 (Entrez Gene)
AKT2; v-akt murine thymoma viral oncogene homolog 2 [EC:2.7.1.-]
AKT3
GeneProduct
735718 (Entrez Gene)
AKT3; v-akt murine thymoma viral oncogene homolog 3 (protein kinase B gamma) [EC:2.7.1.-]
ARAF
GeneProduct
ARAF1; v-raf murine sarcoma 3611 viral oncogene homolog 1 [EC:2.7.1.-]
ARHGEF7
GeneProduct
452673 (Entrez Gene)
ARHGEF7; Rho guanine nucleotide exchange factor (GEF) 7
BCAR1
GeneProduct
454246 (Entrez Gene)
BCAR1; breast cancer anti-estrogen resistance 1
BRAF
GeneProduct
463781 (Entrez Gene)
BRAF; v-raf murine sarcoma viral oncogene homolog B1 [EC:2.7.1.-]
CAPN10
GeneProduct
CAPN10; calpain 10 [EC:3.4.22.17
CAPN11
GeneProduct
462727 (Entrez Gene)
CAPN11; calpain 11 [EC:3.4.22.17]
CAPN1
GeneProduct
451317 (Entrez Gene)
CAPN1; calpain 1 (mu/I) large subunit [EC:3.4.22.17]
CAPN2
GeneProduct
CAPN2; calpain 2 (m/II) large subunit [EC:3.4.22.17]
CAPN3
GeneProduct
453363 (Entrez Gene)
CAPN3; calpain 3 (p94) [EC:3.4.22.17]
CAPN5
GeneProduct
451438 (Entrez Gene)
CAPN5; calpain
CAPN6
GeneProduct
465810 (Entrez Gene)
CAPN6; calpain 6 [EC:3.4.22.17]
CAPN7
GeneProduct
460202 (Entrez Gene)
CAPN7; calpain 7 [EC:3.4.22.17
CAPN9
GeneProduct
457812 (Entrez Gene)
CAPN9; calpain 9 (nCL-4) [EC:3.4.22.17
CAPNS1
GeneProduct
CAPNS1; calpain small subunit 1 [EC:3.4.22.17]
CAV1
GeneProduct
463670 (Entrez Gene)
CAV1; caveolin 1 caveolae protein 22kD
CAV2
GeneProduct
494183 (Entrez Gene)
CAV2; caveolin 2
CAV3
GeneProduct
738786 (Entrez Gene)
CAV3; caveolin 3
CDC42
GeneProduct
456609 (Entrez Gene)
CDC42; cell division cycle 42 (GTP binding protein 25kD)
CRK
GeneProduct
747142 (Entrez Gene)
CRK; v-crk sarcoma virus CT10 oncogene homolog (avian
CSK
GeneProduct
453745 (Entrez Gene)
CSK; c-src tyrosine kinase [EC:2.7.1.112]
DOCK1
GeneProduct
739420 (Entrez Gene)
DOCK1; dedicator of cyto-kinesis
FYN
GeneProduct
462944 (Entrez Gene)
FYN; FYN oncogene related to SRC FGR YES [EC:2.7.1.112]
GIT2
GeneProduct
452227 (Entrez Gene)
GIT2; G protein-coupled receptor kinase-interactor 2
GRB2
GeneProduct
737245 (Entrez Gene)
GRB2; growth factor receptor-bound protein 2
HRAS
GeneProduct
466302 (Entrez Gene)
ILK
GeneProduct
748941 (Entrez Gene)
ILK; integrin-linked kinase [EC:2.7.1.-]
ITGA10
GeneProduct
457982 (Entrez Gene)
ITGA11
GeneProduct
453537 (Entrez Gene)
ITGA1
GeneProduct
461880 (Entrez Gene)
ITGA2
GeneProduct
471550 (Entrez Gene)
ITGA2B
GeneProduct
454730 (Entrez Gene)
ITGA3
GeneProduct
455111 (Entrez Gene)
ITGA4
GeneProduct
470596 (Entrez Gene)
ITGA5
GeneProduct
451958 (Entrez Gene)
ITGA6
GeneProduct
459742 (Entrez Gene)
ITGA7
GeneProduct
451967 (Entrez Gene)
ITGA8
GeneProduct
450323 (Entrez Gene)
ITGA9
GeneProduct
470789 (Entrez Gene)
ITGAD
GeneProduct
468103 (Entrez Gene)
ITGAE
GeneProduct
ITGAL
GeneProduct
454045 (Entrez Gene)
ITGAM
GeneProduct
454069 (Entrez Gene)
ITGAV
GeneProduct
459807 (Entrez Gene)
ITGAX
GeneProduct
454070 (Entrez Gene)
ITGB1
GeneProduct
450396 (Entrez Gene)
ITGB2
GeneProduct
458607 (Entrez Gene)
ITGB3
GeneProduct
468295 (Entrez Gene)
ITGB4
GeneProduct
454887 (Entrez Gene)
ITGB5
GeneProduct
460646 (Entrez Gene)
ITGB6
GeneProduct
459683 (Entrez Gene)
ITGB7
GeneProduct
451934 (Entrez Gene)
ITGB8
GeneProduct
463282 (Entrez Gene)
MAP2K1
GeneProduct
450188 (Entrez Gene)
MAP2K1; mitogen-activated protein kinase kinase 1 [EC:2.7.1.-]
MAP2K2
GeneProduct
456390 (Entrez Gene)
MAP2K2; mitogen-activated protein kinase kinase 2 [EC:2.7.1.-]
MAP2K3
GeneProduct
454515 (Entrez Gene)
MAP2K3; mitogen-activated protein kinase kinase 3 [EC:2.7.1.-]
MAP2K5
GeneProduct
453532 (Entrez Gene)
MAP2K5; mitogen-activated protein kinase kinase 5 [EC:2.7.1.-]
MAP2K6
GeneProduct
468310 (Entrez Gene)
MAP2K6; mitogen-activated protein kinase kinase 6 [EC:2.7.1.-
MAPK10
GeneProduct
461358 (Entrez Gene)
MAPK12
GeneProduct
MAPK12; mitogen-activated protein kinase 12 [EC:2.7.1.-]
MAPK1
GeneProduct
458680 (Entrez Gene)
MAPK1; mitogen-activated protein kinase 1 [EC:2.7.1.-]
MAPK4
GeneProduct
MAPK4; mitogen-activated protein kinase 4 [EC:2.7.1.-]
MAPK6
GeneProduct
453439 (Entrez Gene)
MAPK6; mitogen-activated protein kinase 6 [EC:2.7.1.-]
MAPK7
GeneProduct
454499 (Entrez Gene)
MAPK7; mitogen-activated protein kinase 7 [EC:2.7.1.-
MYLK2
GeneProduct
742591 (Entrez Gene)
MYLK2; myosin light chain kinase 2 skeletal muscle [EC:2.7.1.117
MYO-P
GeneProduct
MYO
GeneProduct
PAK1
GeneProduct
451439 (Entrez Gene)
PAK1; p21/Cdc42/Rac1-activated kinase 1 (STE20 homolog yeast) [EC:2.7.1.-]
PAK2
GeneProduct
460965 (Entrez Gene)
PAK2; p21 (CDKN1A)-activated kinase 2 [EC:2.7.1.-]
PAK3
GeneProduct
450118 (Entrez Gene)
PAK3; p21 (CDKN1A)-activated kinase 3 [EC:2.7.1.-]
PAK4
GeneProduct
PAK4; p21(CDKN1A)-activated kinase 4 [EC:2.7.1.-]
PAK6
GeneProduct
PAK6; p21(CDKN1A)-activated kinase
PDPK1
GeneProduct
PDPK1; 3-phosphoinositide dependent protein kinase-1 [EC:2.7.1.37]
PI5K
GeneProduct
PIK3R2
GeneProduct
455855 (Entrez Gene)
PIK3R2; phosphoinositide-3-kinase regulatory subunit polypeptide 2 (p85 beta)
PTK2
GeneProduct
464422 (Entrez Gene)
PTK2; PTK2 protein tyrosine kinase 2 [EC:2.7.1.112
PXN
GeneProduct
452303 (Entrez Gene)
PXN; paxillin
RAC1
GeneProduct
RAC1; ras-related C3 botulinum toxin substrate 1 (rho family small GTP binding protein Rac1)
RAC2
GeneProduct
742575 (Entrez Gene)
RAC2; ras-related C3 botulinum toxin substrate 2 (rho family small GTP binding protein Rac2)
RAC3
GeneProduct
RAC3; ras-related C3 botulinum toxin substrate 3 (rho family small GTP binding protein Rac3)
RAF1
GeneProduct
460182 (Entrez Gene)
RAF1; v-raf-1 murine leukemia viral oncogene homolog 1 [EC:2.7.1.-]
RAP1A
GeneProduct
469408 (Entrez Gene)
RAP1A; RAP1A member of RAS oncogene family
RAP1B
GeneProduct
452065 (Entrez Gene)
RAP1B; RAP1B member of RAS oncogene family
RAPGEF1
GeneProduct
464812 (Entrez Gene)
GRF2; guanine nucleotide-releasing factor 2 (specific for crk proto-oncogene
RHO
GeneProduct
460685 (Entrez Gene)
RHO; rhodopsin (opsin 2 rod pigment) (retinitis pigmentosa 4 autosomal dominant)
ROCK1
GeneProduct
455326 (Entrez Gene)
ROCK1; Rho-associated coiled-coil containing protein kinase
ROCK2
GeneProduct
470307 (Entrez Gene)
ROCK2; Rho-associated coiled-coil containing protein kinase
SEPP1
GeneProduct
461897 (Entrez Gene)
SEPP1; selenoprotein P plasma
SHC1
GeneProduct
457351 (Entrez Gene)
SHC1; SHC (Src homology 2 domain containing) transforming protein 1
SHC3
GeneProduct
450176 (Entrez Gene)
SHC3; neuronal Sh
SORBS1
GeneProduct
450628 (Entrez Gene)
SH3D5; SH3-domain protein 5 (ponsin
SOS1
GeneProduct
459171 (Entrez Gene)
SOS1; son of sevenless homolog 1 (Drosophila)
SRC
GeneProduct
458229 (Entrez Gene)
SRC; v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian) [EC:2.7.1.112]
TLN1
GeneProduct
TLN1; talin 1
TNS1
GeneProduct
459934 (Entrez Gene)
TNS; tensi
VASP
GeneProduct
468919 (Entrez Gene)
VASP; vasodilator-stimulated phosphoprotein
VAV2
GeneProduct
VAV2; vav 2 oncogene
VAV3
GeneProduct
457076 (Entrez Gene)
VAV3; vav 3 oncogene
VCL
GeneProduct
450531 (Entrez Gene)
VCL; vinculin
ZYX
GeneProduct
ZYX; zyxin
p110
GeneProduct
Annotated Interactions
No annotated interactions
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Try the New WikiPathways
View approved pathways at the new wikipathways.org.Quality Tags
Ontology Terms
Bibliography
History
External references
DataNodes
Annotated Interactions
No annotated interactions