DNA replication (Pan troglodytes)

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Orc3Orc2RNA PrimerRFC140Cdc6DNA polymerase alpha:primase: origin complexMcm10Orc complexp180RNA primer-DNA primerOrc4Orc complexCdc6RNA primer-DNA primerDNAPolymerase ARFC40RNA primer-DNA primer:origin duplex:PCNA4. Switching of origins to post-replicative stateOrc complexUbiquitinp49Orc2OriginOrc2Orc5Orc5DNA polymerase alpha:primase: origin complexMcm10Mcm4RFC36Orc3Phosphorylated Cdc6UbiquitinRFC37GemininMcm6Mcm7Cdt1Mcm4Cdc6Orc4Mcm7Orc complexCdc6Mcm 4,6,7 trimer forms andassociates with the replication forkPre-replicative complexOrc5Mcm23. DNA replication initiation2. Activation of the pre-replicative complexMcm3Processive complexp58PrimaseOrc3Cdt1Pre-replicative complexOrc3p70RFC Heteropentamer:RNA primer-DNA primerPCNA homotrimerRFC Heteropentamer:RNA primer-DNA primer1. Assembly of the pre-replicative complexOrc1Cdt1Cdt1RFC38Phosphorylation ofMcm 2-7 complexMcm3Phosphorylated Orc1Mcm5Cdt1Orc2Mcm5Degraded byproteasomein cytosolOrc complexUbiquitinated Orc1Degraded by proteasome in cytosol5. Leading/lagging strand synthesisMcm6Mcm2Ubiquitinated Cdc6ORC3LCTPRFC1RPA2dUTPRFC5ADPCDC7POLAMCM4CDT1POLD2PCNAGMNNATPATPCDC45LMCM6ORC4LMCM3UBCATPPOLD1ORC5LCDK2dATPCDC6RFC3DBF4POLE2PRIM2AdGTPRFC2ADPMCM7dCTPRFC4MCM5ORC1LPOLD3RPA1POLEUBA52ORC6LGTPRPA3ORC2LRPA4POLD4PRIM1ATPMCM2POLA2UTPMCM10


Description

No description

Comments

GenMAPP notes 
http://www.reactome.org/cgi-bin/eventbrowser?DB=gk_current&ID=69306
GenMAPP remarks 
Based on www.reactome.org
HomologyConvert 
This pathway was inferred from Homo sapiens pathway WP466(r21660) with a 63% conversion rate.

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Ontology Terms

 

Bibliography

  1. Cimbora DM, Groudine M; ''The control of mammalian DNA replication: a brief history of space and timing.''; Cell, 2001 PubMed Europe PMC Scholia
  2. Kelly TJ, Brown GW; ''Regulation of chromosome replication.''; Annu Rev Biochem, 2000 PubMed Europe PMC Scholia
  3. Bell SP, Dutta A; ''DNA replication in eukaryotic cells.''; Annu Rev Biochem, 2002 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
117387view10:32, 21 May 2021EweitzModified title
71683view19:41, 17 October 2013MaintBotAutomated update of data sources
69284view18:40, 8 July 2013MaintBotUpdated to 2013 gpml schema
67166view10:15, 26 June 2013Christine ChichesterOntology Term : 'DNA replication pathway' added !
41593view02:01, 2 March 2011MaintBotRemoved redundant pathway information and comments
35219view15:51, 11 February 2010Thomasadded literature
35209view15:44, 11 February 2010ThomasModified description
35205view15:42, 11 February 2010ThomasModified description
34323view22:13, 9 December 2009MaintBotAutomatic update of empty xrefs
33531view09:34, 1 December 2009MaintBotRemoved group label
31567view21:57, 13 August 2009MaintBotFixed text labels
30434view21:21, 29 July 2009MaintBotNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
ADPMetabolite
ATPMetabolite
CDC45LGeneProduct458651 (Entrez Gene)
CDC6GeneProduct468234 (Entrez Gene)
CDC7GeneProduct469380 (Entrez Gene)
CDK2GeneProduct467032 (Entrez Gene)
CDT1GeneProduct
CTPMetabolite
DBF4GeneProduct472668 (Entrez Gene)
GMNNGeneProduct462477 (Entrez Gene)
GTPMetabolite
MCM10GeneProduct450309 (Entrez Gene)
MCM2GeneProduct460668 (Entrez Gene)
MCM3GeneProduct462763 (Entrez Gene)
MCM4GeneProduct472757 (Entrez Gene)
MCM5GeneProduct458790 (Entrez Gene)
MCM6GeneProduct741695 (Entrez Gene)
MCM7GeneProduct472460 (Entrez Gene)
ORC1LGeneProduct456857 (Entrez Gene)
ORC2LGeneProduct459868 (Entrez Gene)
ORC3LGeneProduct462876 (Entrez Gene)
ORC4LGeneProduct459647 (Entrez Gene)
ORC5LGeneProduct463636 (Entrez Gene)
ORC6LGeneProduct465140 (Entrez Gene)
PCNAGeneProduct458081 (Entrez Gene)
POLAGeneProduct
POLA2GeneProduct451318 (Entrez Gene)
POLD1GeneProduct
POLD2GeneProduct472654 (Entrez Gene)
POLD3GeneProduct451422 (Entrez Gene)
POLD4GeneProduct451366 (Entrez Gene)
POLE2GeneProduct452888 (Entrez Gene)
POLEGeneProduct467165 (Entrez Gene)
PRIM1GeneProduct746924 (Entrez Gene)
PRIM2AGeneProduct
RFC1GeneProduct461174 (Entrez Gene)
RFC2GeneProduct463467 (Entrez Gene)
RFC3GeneProduct452533 (Entrez Gene)
RFC4GeneProduct
RFC5GeneProduct741099 (Entrez Gene)
RPA1GeneProduct454414 (Entrez Gene)
RPA2GeneProduct456680 (Entrez Gene)
RPA3GeneProduct472290 (Entrez Gene)
RPA4GeneProduct736976 (Entrez Gene)
UBA52GeneProduct735674 (Entrez Gene)
UBCGeneProduct467151 (Entrez Gene)
UTPMetabolite
dATPMetabolite
dCTPMetabolite
dGTPMetabolite
dUTPMetabolite

Annotated Interactions

No annotated interactions
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