Mapk cascade (Mus musculus)
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Nucleus
Growth and Mitogenesis
Gi
Gq
Activated
Rap1GAP
Gb and Gg
Apoptosis
Stress Activated Pathways
p38 MAPK Pathway
Rras
GTP
Hras1
Mtap2
GDP
Map2k7
Mbp
Map3k12
Elk1
Mapk14
Kras
Raf1
Map2k2
Map2k1
Mapk1
Mapk12
Map3k2
Rasa3
Mapk10
Araf
Map2k3
RapGAPII
Jun
Plcb3
Map3k3
Sipa1
Map2k4
Map2k6
Map3k1
Braf
Nras
Map2k4
Mapk3
Description
No description
Comments
HomologyConvert
This pathway was inferred from Homo sapiens pathway
WP422(r21570)
with a 90% conversion rate.
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Quality Tags
Ontology Terms
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Bibliography
Plotnikov A, Zehorai E, Procaccia S, Seger R; ''The MAPK cascades: signaling components, nuclear roles and mechanisms of nuclear translocation.''; Biochim Biophys Acta, 2011
PubMed
Europe PMC
Scholia
Orton RJ, Sturm OE, Gormand A, Wolch W, Gilbert DR; ''Computational modelling reveals feedback redundancy within the epidermal growth factor receptor/extracellular-signal regulated kinase signalling pathway.''; IET Syst Biol, 2008
PubMed
Europe PMC
Scholia
History
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Revision
Action
Time
User
Comment
116722
view
10:02, 11 May 2021
Eweitz
Modified title
115735
view
09:47, 9 March 2021
Egonw
Replaced the WP id of a human pathways with the matching cow pathway
115460
view
08:18, 21 February 2021
Egonw
Made a pathway clickable
95771
view
14:24, 19 January 2018
Mkutmon
Homology conversion update
71729
view
20:17, 17 October 2013
MaintBot
Automated update of data sources
71318
view
17:16, 17 October 2013
MaintBot
Automated update of data sources
69104
view
18:12, 8 July 2013
MaintBot
Updated to 2013 gpml schema
67957
view
15:03, 28 June 2013
Ddigles
Ontology Term : 'mitogen activated protein kinase signaling pathway' added !
62830
view
04:45, 3 May 2013
MaintBot
Updated UniProt data source
41289
view
00:22, 2 March 2011
MaintBot
Removed redundant pathway information and comments
35459
view
11:53, 12 February 2010
Michiel
Added ref
35431
view
11:13, 12 February 2010
Michiel
Modified description
35430
view
11:12, 12 February 2010
Michiel
Modified description
35429
view
11:10, 12 February 2010
Michiel
Added literature reference
34388
view
22:50, 9 December 2009
MaintBot
Automatic update of empty xrefs
32979
view
23:26, 29 September 2009
MaintBot
added xrefs
32377
view
16:52, 15 August 2009
MaintBot
Fixed text labels
32013
view
13:21, 14 August 2009
MaintBot
Fixed group labels
31413
view
20:54, 13 August 2009
MaintBot
Fixed text labels
30851
view
00:07, 30 July 2009
MaintBot
Converted from Homo sapiens
21207
view
11:31, 14 November 2008
MaintBot
[[Pathway:Mus musculus:MAPK Cascade]] moved to [[Pathway:WP251]]: Moved to stable identifier
8244
view
13:46, 7 January 2008
MaintBot
[[Pathway:Mouse:MAPK Cascade]] moved to [[Pathway:Mus musculus:MAPK Cascade]]: Renaming species
7742
view
16:14, 18 December 2007
MaintBot
fixed category names
7275
view
12:41, 4 November 2007
MaintBot
Added categories to GPML
19506
view
22:19, 22 May 2007
I.Reyes
gpml file for [[Mouse:MAPK_Cascade]]
6473
view
22:19, 22 May 2007
Nsalomonis
gpml file for [[Mouse:MAPK_Cascade]]
External references
DataNodes
View all...
Name
Type
Database reference
Comment
Araf
GeneProduct
11836 (Entrez Gene)
Braf
GeneProduct
109880 (Entrez Gene)
Elk1
GeneProduct
13712 (Entrez Gene)
GDP
Metabolite
HMDB01201 (HMDB)
GTP
Metabolite
HMDB01273 (HMDB)
Hras1
GeneProduct
15461 (Entrez Gene)
Jun
GeneProduct
16476 (Entrez Gene)
Kras
GeneProduct
16653 (Entrez Gene)
Map2k1
GeneProduct
26395 (Entrez Gene)
Map2k2
GeneProduct
26396 (Entrez Gene)
Map2k3
GeneProduct
26397 (Entrez Gene)
Map2k4
GeneProduct
26398 (Entrez Gene)
Map2k6
GeneProduct
26399 (Entrez Gene)
Map2k7
GeneProduct
26400 (Entrez Gene)
Map3k12
GeneProduct
26404 (Entrez Gene)
Map3k1
GeneProduct
26401 (Entrez Gene)
Map3k2
GeneProduct
26405 (Entrez Gene)
Map3k3
GeneProduct
26406 (Entrez Gene)
Mapk10
GeneProduct
26414 (Entrez Gene)
Mapk12
GeneProduct
29857 (Entrez Gene)
Mapk1
GeneProduct
26413 (Entrez Gene)
Mapk14
GeneProduct
26416 (Entrez Gene)
Mapk3
GeneProduct
26417 (Entrez Gene)
Mbp
GeneProduct
17196 (Entrez Gene)
Mtap2
GeneProduct
17756 (Entrez Gene)
Nras
GeneProduct
18176 (Entrez Gene)
Plcb3
GeneProduct
18797 (Entrez Gene)
Raf1
GeneProduct
110157 (Entrez Gene)
RapGAPII
GeneProduct
Rasa3
GeneProduct
19414 (Entrez Gene)
Rras
GeneProduct
20130 (Entrez Gene)
Sipa1
GeneProduct
20469 (Entrez Gene)
not confirmed SwissProt ID - mu: SPA1 MOUSE
Annotated Interactions
No annotated interactions
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Try the New WikiPathways
View approved pathways at the new wikipathways.org.Quality Tags
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Annotated Interactions
No annotated interactions