ACE inhibitor pathway (Bos taurus)

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1Cell MembraneAGTR2BradykininACEKNG1AGTRENACE InhibitorAGTR1ACEBDKRB2Angiotensin IIAldosteroneAngiotensin INOS3


Description

The renin-angiotensin-aldosterone system (RAAS) is central to the control of blood pressure and the target of several types of anti-hypertensive drugs. This pathway depicts a simplified representation of the pharmacodynamics (PD) of RAAS-acting drugs including candidate genes for the pharmacogenomics (PGx) of ACE inhibitors, angiotensin receptor blockers (ARBs), renin inhibitor aliskiren and aldosterone receptor antagonists. Source: PharmGKB (http://www.pharmgkb.org/do/serve?objId=PA2023&objCls=Pathway)

Comments

GenMAPP notes 
https://www.pharmgkb.org/search/pathway/ace-inhibitor.jsp Model non-tissue specific cell displaying genes which may be involved in the ACE inhibitor pathway.
GenMAPP remarks 
Adapted from PharmGKB (right click for info)
HomologyConvert 
This pathway was inferred from Homo sapiens pathway WP554(r30178) with a 77% conversion rate.

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Ontology Terms

 

Bibliography

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  1. Hamming I, Cooper ME, Haagmans BL, Hooper NM, Korstanje R, Osterhaus AD, Timens W, Turner AJ, Navis G, van Goor H; ''The emerging role of ACE2 in physiology and disease.''; J Pathol, 2007 PubMed Europe PMC Scholia
  2. Athyros VG, Mikhailidis DP, Kakafika AI, Tziomalos K, Karagiannis A; ''Angiotensin II reactivation and aldosterone escape phenomena in renin-angiotensin-aldosterone system blockade: is oral renin inhibition the solution?''; Expert Opin Pharmacother, 2007 PubMed Europe PMC Scholia
  3. Ferreira AJ, Raizada MK; ''Are we poised to target ACE2 for the next generation of antihypertensives?''; J Mol Med, 2008 PubMed Europe PMC Scholia
  4. Bassett MH, White PC, Rainey WE; ''The regulation of aldosterone synthase expression.''; Mol Cell Endocrinol, 2004 PubMed Europe PMC Scholia
  5. McDowell SE, Coleman JJ, Ferner RE; ''Systematic review and meta-analysis of ethnic differences in risks of adverse reactions to drugs used in cardiovascular medicine.''; BMJ, 2006 PubMed Europe PMC Scholia
  6. Maron BA, Leopold JA; ''Mineralocorticoid receptor antagonists and endothelial function.''; Curr Opin Investig Drugs, 2008 PubMed Europe PMC Scholia
  7. Batenburg WW, Jan Danser AH; ''The (pro)renin receptor: a new addition to the renin-angiotensin system?''; Eur J Pharmacol, 2008 PubMed Europe PMC Scholia
  8. Weir MR; ''Effects of renin-angiotensin system inhibition on end-organ protection: can we do better?''; Clin Ther, 2007 PubMed Europe PMC Scholia
  9. Schwartz GL, Turner ST; ''Pharmacogenetics of antihypertensive drug responses.''; Am J Pharmacogenomics, 2004 PubMed Europe PMC Scholia
  10. Huang Y, Wongamorntham S, Kasting J, McQuillan D, Owens RT, Yu L, Noble NA, Border W; ''Renin increases mesangial cell transforming growth factor-beta1 and matrix proteins through receptor-mediated, angiotensin II-independent mechanisms.''; Kidney Int, 2006 PubMed Europe PMC Scholia

History

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CompareRevisionActionTimeUserComment
117471view10:58, 21 May 2021EweitzModified title
105956view11:48, 16 August 2019MaintBotHMDB identifier normalization
96331view09:34, 8 March 2018Mkutmonremove redundant ontology tag
96330view09:34, 8 March 2018MkutmonOntology Term : 'angiotensin signaling pathway' added !
96329view09:33, 8 March 2018MkutmonUpdated homology conversion
80846view15:28, 30 June 2015Mkutmonhomology conversion
79145view05:51, 5 March 2015KhanspersModified title
79144view05:42, 5 March 2015KhanspersUpdated conversion from Hs
71401view19:00, 17 October 2013MaintBotAutomated update of data sources
67016view09:53, 26 June 2013Christine ChichesterOntology Term : 'ACE inhibitor drug pathway' added !
63332view21:13, 9 May 2013MaintBotUpdated to 2013 gpml schema
57076view20:11, 20 January 2013Egonw
40511view19:29, 1 March 2011MaintBotRemoved redundant pathway information and comments
35048view09:36, 11 February 2010Thomasremoved genmapp notes (invalid link)
35040view09:29, 11 February 2010ThomasModified description
33754view23:59, 8 December 2009MaintBotAutomatic update of empty xrefs
31672view11:42, 14 August 2009MaintBotFixed group labels
30602view22:16, 29 July 2009MaintBotNew pathway

External references

DataNodes

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NameTypeDatabase referenceComment
ACE InhibitorMetabolite
ACEGeneProduct614289 (Entrez Gene)
AGTGeneProduct527114 (Entrez Gene)
AGTR1GeneProduct281607 (Entrez Gene)
AGTR2GeneProduct407157 (Entrez Gene)
AldosteroneMetaboliteC01780 (Kegg Compound)
Angiotensin IMetabolite3081372 (PubChem)
Angiotensin IIMetaboliteHMDB01035 (HMDB)
BDKRB2GeneProduct538896 (Entrez Gene)
BradykininMetaboliteHMDB04246 (HMDB)
KNG1GeneProduct280833 (Entrez Gene)
NOS3GeneProduct287024 (Entrez Gene)
RENGeneProduct511831 (Entrez Gene)

Annotated Interactions

No annotated interactions
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