Apoptosis (Canis familiaris)

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2eMitochondrionbCaspApoptosispp53 RelatedInhibitor of Cell DeathbIGF1R signaling pathwayActivator of Cell DeathFas LigandpDNA FragmentationebInterferon regulatory factorsDegradationCASP8FASLGBADCASP2TNFRSF1AHRKIRF6TP73TRADDTNFRSF25TRAF3MYCBADIGF1IKBKGTRAF1BCL2CASP3HELLSBIRC3IRF5NFKBIANFKBIETRAF2Bak1CDKN2ARELACASP6NFKB1TNFSF10RHOXF2BIRC5RIPK1CASP10IRF1CHUKBNIP3LCRADDMAPK10TNFRSF1BBCL2L11BIDBOKTNFIGF2NFKBIBTRADDIRF2IGF1RLTANFKBIBMCL1IRF7DIABLOGZMBNFKBIABCL2L1IRF3RIPK1FASAPAF1BBC3TNFRSF10BRHOXF2CASP1BAXCASP4CYCSCASP9PMAIP1MAP2K4FADDIRF4TNFRSF21IKBKBTP53MDM2CASP7RHOXF2PRF1MAP3K1DFFAAKT1CFLARJUNXIAPNFKB1RELATNFRSF1ADFFBBCL2L2NFKBIEPIK3R1BIRC21


Description

Apoptosis is a distinct form of cell death that is functionally and morphologically different from necrosis. Nuclear chromatin condensation, cytoplasmic shrinking, dilated endoplasmic reticulum, and membrane blebbing characterize apoptosis in general. Mitochondria remain morphologically unchanged. In 1972 Kerr et al introduced the concept of apoptosis as a distinct form of "cell-death", and the mechanisms of various apoptotic pathways are still being revealed today.

Comments

HomologyConvert 
This pathway was inferred from Homo sapiens pathway WP254(r29955) with a 87% conversion rate.

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Ontology Terms

 

Bibliography

  1. Lakin ND, Jackson SP; ''Regulation of p53 in response to DNA damage.''; Oncogene, 1999 PubMed Europe PMC Scholia
  2. Bose I, Ghosh B; ''The p53-MDM2 network: from oscillations to apoptosis.''; J Biosci, 2007 PubMed Europe PMC Scholia

History

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CompareRevisionActionTimeUserComment
87016view14:46, 15 July 2016MkutmonOntology Term : 'apoptotic cell death pathway' added !
68582view23:09, 5 July 2013MaintBotUpdated to 2013 gpml schema
48174view20:38, 9 May 2012MaintBotUpdating from human to fix xrefs
40741view21:53, 1 March 2011MaintBotRemoved redundant pathway information and comments
35101view13:08, 11 February 2010MartijnVanIerseladded lit. ref.
34016view18:44, 9 December 2009MaintBotAutomatic update of empty xrefs
31758view12:05, 14 August 2009MaintBotFixed group labels
30706view22:51, 29 July 2009MaintBotNew pathway

External references

DataNodes

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NameTypeDatabase referenceComment
AKT1GeneProduct490878 (Entrez Gene)
APAF1GeneProduct482620 (Entrez Gene)
BADGeneProduct483763 (Entrez Gene)
BAXGeneProduct403523 (Entrez Gene)
BBC3GeneProduct612153 (Entrez Gene)
BCL2GeneProduct403416 (Entrez Gene)
BCL2L11GeneProduct612867 (Entrez Gene)
BCL2L1GeneProduct403618 (Entrez Gene)
BCL2L2GeneProduct
BIDGeneProduct486607 (Entrez Gene)
BIRC2GeneProduct479464 (Entrez Gene)
BIRC3GeneProduct489433 (Entrez Gene)
BIRC5GeneProduct442936 (Entrez Gene)
BNIP3LGeneProduct608552 (Entrez Gene)
BOKGeneProduct
Bak1GeneProduct481744 (Entrez Gene)
CASP1GeneProduct
CASP10GeneProduct488472 (Entrez Gene)
CASP2GeneProduct482737 (Entrez Gene)
CASP3GeneProduct403567 (Entrez Gene)
CASP4GeneProduct403724 (Entrez Gene)
CASP6GeneProduct487899 (Entrez Gene)
CASP7GeneProduct486896 (Entrez Gene)
CASP8GeneProduct488473 (Entrez Gene)
CASP9GeneProduct487432 (Entrez Gene)
CDKN2AGeneProduct100271861 (Entrez Gene)
CFLARGeneProduct488471 (Entrez Gene)
CHUKGeneProduct477796 (Entrez Gene)
CRADDGeneProduct482604 (Entrez Gene)
CYCSGeneProduct475258 (Entrez Gene)
DFFAGeneProduct487449 (Entrez Gene)
DFFBGeneProduct489623 (Entrez Gene)
DIABLOGeneProduct477463 (Entrez Gene)
FADDGeneProduct
FASGeneProduct486469 (Entrez Gene)
FASLGGeneProduct442968 (Entrez Gene)
GZMBGeneProduct490630 (Entrez Gene)
HELLSGeneProduct486809 (Entrez Gene)
HRKGeneProduct612984 (Entrez Gene)
IGF1GeneProduct610255 (Entrez Gene)
IGF1RGeneProduct442951 (Entrez Gene)
IGF2GeneProduct483664 (Entrez Gene)
IKBKBGeneProduct482839 (Entrez Gene)
IKBKGGeneProduct
IRF1GeneProduct481500 (Entrez Gene)
IRF2GeneProduct475633 (Entrez Gene)
IRF3GeneProduct476412 (Entrez Gene)
IRF4GeneProduct
IRF5GeneProduct482264 (Entrez Gene)
IRF6GeneProduct480015 (Entrez Gene)
IRF7GeneProduct
JUNGeneProduct609429 (Entrez Gene)
LTAGeneProduct607183 (Entrez Gene)
MAP2K4GeneProduct489508 (Entrez Gene)
MAP3K1GeneProduct478061 (Entrez Gene)
MAPK10GeneProduct478464 (Entrez Gene)
MCL1GeneProduct403537 (Entrez Gene)
MDM2GeneProduct403693 (Entrez Gene)
MYCGeneProduct403924 (Entrez Gene)
NFKB1GeneProduct442859 (Entrez Gene)
NFKBIAGeneProduct480291 (Entrez Gene)
NFKBIBGeneProduct484519 (Entrez Gene)
NFKBIEGeneProduct609647 (Entrez Gene)
PIK3R1GeneProduct487235 (Entrez Gene)
PMAIP1GeneProduct
PRF1GeneProduct489030 (Entrez Gene)
RELAGeneProduct483729 (Entrez Gene)
RHOXF2GeneProduct611154 (Entrez Gene)
RIPK1GeneProduct488195 (Entrez Gene)
TNFGeneProduct403922 (Entrez Gene)
TNFRSF10BGeneProduct
TNFRSF1AGeneProduct403634 (Entrez Gene)
TNFRSF1BGeneProduct487437 (Entrez Gene)
TNFRSF21GeneProduct609964 (Entrez Gene)
TNFRSF25GeneProduct489632 (Entrez Gene)
TNFSF10GeneProduct100174780 (Entrez Gene)
TP53GeneProduct403869 (Entrez Gene)
TP73GeneProduct489620 (Entrez Gene)
TRADDGeneProduct611262 (Entrez Gene)
TRAF1GeneProduct612709 (Entrez Gene)
TRAF2GeneProduct480673 (Entrez Gene)
TRAF3GeneProduct490867 (Entrez Gene)
XIAPGeneProduct442989 (Entrez Gene)

Annotated Interactions

No annotated interactions
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