Apoptosis (Danio rerio)

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2DegradationbInhibitor of Cell DeathbDNA FragmentationCaspeIGF1R signaling pathwayeMitochondrionApoptosisbppActivator of Cell DeathInterferon regulatory factorsp53 RelatedFas LigandTNFRSF10BTNFMYCcasp8LOC796190bcl2lcflarLOC792201ripk1likbkbtnfrsf21tp73LOC792354PRF1mapk10GZMBtraddfastptecasp7craddrelairf11faddtp53DIABLOirf3BCL2juntraf1CH73-170D1.2PMAIP1tnfrsf1aBADIRF5NFKBIBhellsCDKN2Abirc2zgc:194486dffbapaf1igf1LOC564899BADbirc5aBBC3irf6tptechukNFKB1zgc:158276IGF1RtraddIGF2BIDmdm2BNIP3LBAK1irf7casp6faslgBCL2L11BCL2L2tnfsf10l2NFKBIBtraf3TNFRSF25HRKMCL1BIRC3xiaptnfrsf1azgc:158276NFKBIAcasp9relaikbkgLTABAXripk1lCASP4tptebokacasp8l2casp2irf2aNFKBIALOC100005446CASP1LOC557176NFKB1CYCSCASP31


Description

Apoptosis is a distinct form of cell death that is functionally and morphologically different from necrosis. Nuclear chromatin condensation, cytoplasmic shrinking, dilated endoplasmic reticulum, and membrane blebbing characterize apoptosis in general. Mitochondria remain morphologically unchanged. In 1972 Kerr et al introduced the concept of apoptosis as a distinct form of "cell-death", and the mechanisms of various apoptotic pathways are still being revealed today.

Comments

HomologyConvert 
This pathway was inferred from Homo sapiens pathway WP254(r29955) with a 61% conversion rate.

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Quality Tags

Ontology Terms

 

Bibliography

  1. Mott JL, Kobayashi S, Bronk SF, Gores GJ; ''mir-29 regulates Mcl-1 protein expression and apoptosis.''; Oncogene, 2007 PubMed Europe PMC Scholia
  2. Lakin ND, Jackson SP; ''Regulation of p53 in response to DNA damage.''; Oncogene, 1999 PubMed Europe PMC Scholia
  3. Park SY, Lee JH, Ha M, Nam JW, Kim VN; ''miR-29 miRNAs activate p53 by targeting p85 alpha and CDC42.''; Nat Struct Mol Biol, 2009 PubMed Europe PMC Scholia
  4. Xiong Y, Fang JH, Yun JP, Yang J, Zhang Y, Jia WH, Zhuang SM; ''Effects of microRNA-29 on apoptosis, tumorigenicity, and prognosis of hepatocellular carcinoma.''; Hepatology, 2010 PubMed Europe PMC Scholia
  5. Bose I, Ghosh B; ''The p53-MDM2 network: from oscillations to apoptosis.''; J Biosci, 2007 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
95786view14:37, 19 January 2018MkutmonHomology conversion update
91982view08:13, 11 April 2017LWackersReplaced human genes with zebrafish orthologs where possible; updated old annotations.
87015view14:45, 15 July 2016MkutmonOntology Term : 'apoptotic cell death pathway' added !
71509view19:21, 17 October 2013MaintBotAutomated update of data sources
68635view04:49, 6 July 2013MaintBotUpdated to 2013 gpml schema
47917view21:43, 18 April 2012Khanspersupdated xrefs
40802view22:16, 1 March 2011MaintBotRemoved redundant pathway information and comments
35102view13:09, 11 February 2010MartijnVanIerseladded lit. ref.
34191view21:25, 9 December 2009MaintBotAutomatic update of empty xrefs
31936view12:56, 14 August 2009MaintBotFixed group labels
31061view01:26, 30 July 2009MaintBotNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
BADGeneProduct58100 (Entrez Gene)
BAK1GeneProduct
BAXGeneProduct
BBC3GeneProduct751763 (Entrez Gene)
BCL2GeneProduct570772 (Entrez Gene)
BCL2L11GeneProduct100190951 (Entrez Gene)
BCL2L2GeneProduct
BIDGeneProduct
BIRC3GeneProduct
BNIP3LGeneProduct554650 (Entrez Gene)
CASP1GeneProduct
CASP3GeneProduct
CASP4GeneProduct
CDKN2AGeneProduct
CH73-170D1.2GeneProduct100002070 (Entrez Gene)
CYCSGeneProduct
DIABLOGeneProduct
GZMBGeneProduct
HRKGeneProduct
IGF1RGeneProduct
IGF2GeneProduct
IRF5GeneProduct405811 (Entrez Gene)
LOC100005446GeneProduct100005446 (Entrez Gene)
LOC557176GeneProduct557176 (Entrez Gene)
LOC564899GeneProduct564899 (Entrez Gene)
LOC792201GeneProduct792201 (Entrez Gene)
LOC792354GeneProduct792354 (Entrez Gene)
LOC796190GeneProduct796190 (Entrez Gene)
LTAGeneProduct554305 (Entrez Gene)
MCL1GeneProduct
MYCGeneProduct
NFKB1GeneProduct565756 (Entrez Gene)
NFKBIAGeneProduct
NFKBIBGeneProduct
PMAIP1GeneProduct751765 (Entrez Gene)
PRF1GeneProduct
TNFGeneProduct
TNFRSF10BGeneProduct
TNFRSF25GeneProduct
apaf1GeneProduct58131 (Entrez Gene)
bcl2lGeneProduct114401 (Entrez Gene)
birc2GeneProduct373107 (Entrez Gene)
birc5aGeneProduct373110 (Entrez Gene)
bokaGeneProduct445218 (Entrez Gene)
casp2GeneProduct373118 (Entrez Gene)
casp6GeneProduct552927 (Entrez Gene)
casp7GeneProduct553634 (Entrez Gene)
casp8GeneProduct58022 (Entrez Gene)
casp8l2GeneProduct557302 (Entrez Gene)
casp9GeneProduct492763 (Entrez Gene)
cflarGeneProduct373114 (Entrez Gene)
chukGeneProduct393287 (Entrez Gene)
craddGeneProduct450046 (Entrez Gene)
dffbGeneProduct373130 (Entrez Gene)
faddGeneProduct562317 (Entrez Gene)
fasGeneProduct768248 (Entrez Gene)
faslgGeneProduct735295 (Entrez Gene)
hellsGeneProduct553328 (Entrez Gene)
igf1GeneProduct114433 (Entrez Gene)
ikbkbGeneProduct563560 (Entrez Gene)
ikbkgGeneProduct541530 (Entrez Gene)
irf11GeneProduct792160 (Entrez Gene)
irf2aGeneProduct325410 (Entrez Gene)
irf3GeneProduct564854 (Entrez Gene)
irf6GeneProduct393570 (Entrez Gene)
irf7GeneProduct393650 (Entrez Gene)
junGeneProduct335916 (Entrez Gene)
mapk10GeneProduct569698 (Entrez Gene)
mdm2GeneProduct30637 (Entrez Gene)
relaGeneProduct415099 (Entrez Gene)
ripk1lGeneProduct567460 (Entrez Gene)
tnfrsf1aGeneProduct406471 (Entrez Gene)
tnfrsf21GeneProduct564874 (Entrez Gene)
tnfsf10l2GeneProduct436866 (Entrez Gene)
tp53GeneProduct30590 (Entrez Gene)
tp73GeneProduct368221 (Entrez Gene)
tpteGeneProduct327292 (Entrez Gene)
traddGeneProduct58130 (Entrez Gene)
traf1GeneProduct100148503 (Entrez Gene)
traf3GeneProduct445119 (Entrez Gene)
xiapGeneProduct373108 (Entrez Gene)
zgc:158276GeneProduct790944 (Entrez Gene)
zgc:194486GeneProduct568951 (Entrez Gene)

Annotated Interactions

No annotated interactions
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