Alpha 6 beta 4 signaling (Homo sapiens)

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"The integrin alpha6-beta4 is a receptor for various Iaminin isofoms. It is strongly expressed on basal keratinocytes, in which it is concentrated in specialized adhesion structures called hemidesmosomes. Abnormal expression of the integrin alpha6-beta4 in the suprabasal cell layers has been associated with an increased malignancy of squamous cell carcinomas. The continued expression of alpha6-beta4, when cells leave the basement membrane and migrate into the upper layers, may contribute to a reduced dependence of growth on anchorage and thus to an increased cell proliferation. Recent studies have identified the alpha6-beta4 integrin as a sigalling molecule that rates proliferation in response to the interaction of cells with Iaminin." Source: Dr. A. Sonnenberg - http://www.onderzoekinformatie.nl/en/oi/nod/onderzoek/OND1270125/

GenMAPP notes 

NetPath 13: IL-1 Signaling Pathway

NetPath (http://www.netpath.org) is a collaborative project between PandeyLab at Johns Hopkins University (http://pandeylab.igm.jhmi.edu) and the Institute of Bioinformatics (http://www.ibioinformatics.org). If you use this pathway, you must cite the NetPath website until the pathway is published.

GenMAPP remarks 

http://www.netpath.org