Synthesis and degradation of ketone bodies (Mus musculus)
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1
Fatty acid beta-oxidation
Fatty acid metabolism
Glycolysis
(HMG-CoA cycle)
Pyruvate metabolism
* pathway-regulated enzymes: HMG-CoA synthase, mt
Sterol biosynthesis
Hmgcs2
Acetoacetate
Acat1
Oxct1
Hmgcl
3-Hydroxy-3-methylglutaryl-CoA
Acetyl-CoA
Acetoacetyl-CoA
Acetyl-CoA
3-Hydroxy-butyrate
Bdh1
Description
No description
Comments
GenMAPP notes
Ketogenesis (Human)
GenMAPP remarks
Adapted from KEGG
HomologyConvert
This pathway was inferred from Homo sapiens pathway
WP311(r21335)
with a 55% conversion rate.
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Bibliography
Fukao T, Lopaschuk GD, Mitchell GA; ''Pathways and control of ketone body metabolism: on the fringe of lipid biochemistry.''; Prostaglandins Leukot Essent Fatty Acids, 2004
PubMed
Europe PMC
Scholia
History
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Compare
Revision
Action
Time
User
Comment
116831
view
10:30, 14 May 2021
Eweitz
Modified title
91902
view
20:58, 3 April 2017
Khanspers
removed GenMAPP comments
70481
view
10:18, 7 August 2013
Egonw
Give the other Acetyl-CoA the same CAS id as the first.
70040
view
02:13, 12 July 2013
AlexanderPico
Added metabolite xrefs
70039
view
02:11, 12 July 2013
AlexanderPico
Fixed interactions
69191
view
18:22, 8 July 2013
MaintBot
Updated to 2013 gpml schema
67678
view
11:48, 26 June 2013
Ddigles
Ontology Term : 'ketone bodies metabolic pathway' added !
48252
view
21:38, 17 May 2012
Khanspers
Updating PubChem xrefs
48226
view
05:32, 17 May 2012
MaintBot
Automatic update of PubChem xrefs
42734
view
22:42, 24 April 2011
MaintBot
fixed null db refs
41382
view
00:29, 2 March 2011
MaintBot
Removed redundant pathway information and comments
35390
view
09:35, 12 February 2010
Thomas
fixed connections
35358
view
09:08, 12 February 2010
Thomas
Modified description
35356
view
09:08, 12 February 2010
Thomas
added literature
34422
view
23:18, 9 December 2009
MaintBot
Automatic update of empty xrefs
30856
view
00:09, 30 July 2009
MaintBot
Converted from Homo sapiens
21822
view
11:32, 14 November 2008
MaintBot
[[Pathway:Mus musculus:Synthesis and Degradation of Ketone Bodies KEGG]] moved to [[Pathway:WP543]]: Moved to stable identifier
8422
view
13:46, 7 January 2008
MaintBot
[[Pathway:Mouse:Synthesis and Degradation of Ketone Bodies KEGG]] moved to [[Pathway:Mus musculus:Synthesis and Degradation of Ketone Bodies KEGG]]: Renaming species
7828
view
16:20, 18 December 2007
MaintBot
fixed category names
7402
view
12:42, 4 November 2007
MaintBot
Added categories to GPML
6499
view
22:19, 22 May 2007
N.Reyes
gpml file for [[Mouse:Synthesis_and_Degradation_of_Ketone_Bodies_KEGG]]
External references
DataNodes
View all...
Name
Type
Database reference
Comment
3-Hydroxy-3-methylglutaryl-CoA
Metabolite
3-Hydroxy-butyrate
Metabolite
3037032 (PubChem)
Acat1
GeneProduct
110446 (Entrez Gene)
Acetoacetate
Metabolite
6971017 (PubChem)
Acetoacetyl-CoA
Metabolite
Acetyl-CoA
Metabolite
Bdh1
GeneProduct
71911 (Entrez Gene)
Hmgcl
GeneProduct
15356 (Entrez Gene)
Hmgcs2
GeneProduct
15360 (Entrez Gene)
Oxct1
GeneProduct
67041 (Entrez Gene)
Annotated Interactions
No annotated interactions
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