EGF/EGFR signaling (Homo sapiens)

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1PM(Protein-protein interaction)CYMAPMNUEnzyme complexMACYCYENNUProteins in a complex interactionCYNUCYMACYMolecule in the pathwayCYAcetylationCYPMENCYDeacetylationLigandMitochondrionEndosomePMCYCYCYCYGene SymbolCYCYAutophosphorylationMethylationCYCYPMCYNUPMPMUbiquitinationMARecruitmentCYECPMPMCYMANUMAAutodephosphorylationCYDeubiquitinationNUCYMAMACYMAGlycosylationCYPMMolecular associationNUInhibitionNUMAMAControlReceptorDephosphorylationNUMAMAPMPMMACytoplasmMTMAPMPMPMMADCYMAPhosphorylationCYDPMERGolgi apparatusGOProteolytic cleavageNUNUPalmitoylationMAPMDemethylationNUPMCYAccession Number : NetPath 4; cellmap:4CYTranslocationCYSumoylationENPMExtracellularMACYNUCYMACYReaction through unknown mechanisms/moleculesActivationNUMANUNUNUNUCYDesumoylationPMNucleusPMNUCYPlasma membraneDCYNUEndoplasmic reticulumPMPEBP1ELK4TNIP1PTK6SNRPD2PIK3CAKRT7CRKSMAD3MYCMCF2PIK3CDRPS6KA3HIST3H3STAT5APLCG2GRB7GAB1MAP3K1ELF3MAPK14DNM1GAB2ZNF259AP2A1EGFATF1CBLCSTAT5BDUSP1ZNF259PKN2DUSP1SH2D3CSTXBP1STAT3ARF4PTPN11PLCG1STAT5APIK3C2BSH3GL2EGFRMAP3K3KRT17RPS6KA1STAT3PIK3R3PTPN6EEF1A1NCK2SHC1EPN1EPPK1REPS1ELF3TNK2PRKCMPIK3CGNRASFOXO1ARPS6KA2GIT1RPS6KA5STAT3VAV1SH2D3CEGFAPPLCDC42CASP9RAF1MAPK8RALGDSSH3BGRLPLD1PRKCGCTNND1PRKCIEGFRSHOC2STAT1MAP3K14SPRY2PLD1KLF11MAP2K5RAF1GAB1FOXO1AVAV3SIN3ASTAT2SH3GL3KRT18AKT1HRASELK1PTPN12CAMK2ARGS16SP1PLCG1SOS2JAK2MAP2K1MAPK1SNCAHIP1YWHABSH3GL2KRAS2ERRFI1CEBPASTAT2EGFCEACAM1PRKCB1NDUFA13SMAD2JUNDMAPK1TGIFEPS15PLCG2PTPRRSMAD2RASA1PTPN6ARF4PLEC1GRB10SRCMAP2K2RALBP1CBLBREPS2SMAD3BCAR1RAB5ADIP13BGRB14HAT1JAK1GRB2PTK2BMAPK3MAP2K1NCK1VAV2GJA1CRKLPXNWNK1RFXANKMAPK7APPLITCHKRT8EPS15L1PRKCZMAP3K2CBLCAV1MAP3K2CSKFOSEGFRMAP3K4USP6NLPLSCR1INPPL1PLD2RAC1STAT1RBBP7SOCS3DDEF1PRKAR1AJUNPIK3R1ARAFARF4SOS1HDCREB1BCAR1SOCS1STXBP1DIP13BSTAT1SPRY2RALBRIPK1WASLPRKCAEEF1A1SH3KBP1MAP2K7HDAC1PIK3CBEGFRPRKCACEBPBSHC1EPS15MTA2RPS6KA3PITPNAABI1PAK1MAP2K3PTPN5PIK3R2EPS8APPLCAV2DOK2


Description

"The androgen receptor is a member of the nuclear receptor family of ligand activated transcription factors. These receptors bind to steroid hormones, thyroid hormone, retinoids and vitamin D among others, dimerize and bind to DNA. Its ligands include testosterone, dehydroepiandrosterone and androstenedione. Stimulation of the receptor activates the SMAD signaling module." Source: http://www.netpath.org/pathways?path_id=NetPath_4

Comments

GenMAPP notes 
NetPath 4; cellmap:4 - EGFR1 Signaling Pathway.This cancer signaling pathway is available at Cancer Cell Map (http://cancer.cellmap.org) and NetPath (http://www.netpath.org) and is part of a collaborative project between the Computational Biology Center at Memorial Sloan-Kettering Cancer Center (http://cbio.mskcc.org), PandeyLab at Johns Hopkins University (http://pandeylab.igm.jhmi.edu) and Institute of Bioinformatics (http://www.ibioinformatics.org). If you use this pathway, you must cite the Cancer Cell Map and NetPath websites until the pathway is published.
GenMAPP remarks 
http://cancer.cellmap.org; http://www.netpath.org

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Bibliography

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History

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CompareRevisionActionTimeUserComment
129679view00:46, 22 May 2024EweitzModified title
126309view17:28, 20 April 2023EgonwLicense is CCZero
120689view12:47, 23 December 2021EweitzStandardize font, weight, case
118995view09:26, 8 June 2021FinterlyRemoved empty Comment
116546view12:14, 7 May 2021EweitzModified title
115923view20:35, 20 March 2021EgonwModified description
111019view14:22, 30 June 2020L DupuisConverted interaction lines in legend to graphical lines
106392view21:27, 28 August 2019KhanspersModified description
105574view06:29, 9 August 2019KhanspersModified description
79266view20:32, 19 March 2015ZariChenged Identifier for PXN
78502view10:29, 7 January 2015MaintBotadded missing graphIds
72106view22:03, 24 October 2013AlexanderPicoadded xrefs
71357view18:35, 17 October 2013MaintBotAutomated update of data sources
70625view21:22, 16 August 2013MaintBotUpdated xrefs from Anatoly Urisman
67174view10:16, 26 June 2013Christine ChichesterOntology Term : 'epidermal growth factor/neuregulin signaling pathway' added !
63177view20:30, 8 May 2013MaintBotUpdating gpml version
47973view14:23, 23 April 2012NetPathModified description
44600view21:09, 21 September 2011KhanspersUpdating content to NetSlim
44120view20:50, 24 August 2011KhanspersReverted to version '23:15, 1 March 2011' by Khanspers
44017view22:41, 22 August 2011Khanspers
44009view22:10, 22 August 2011KhanspersModified description
44008view22:05, 22 August 2011KhanspersModified description
44007view22:03, 22 August 2011KhanspersModified description
44006view22:00, 22 August 2011KhanspersUpdating pathway from NetSlim
41034view23:15, 1 March 2011MaintBotRemoved redundant pathway information and comments
35716view23:27, 12 February 2010AlexanderPico
35432view11:23, 12 February 2010MichielChanged literature reference
35428view11:06, 12 February 2010MichielAdded literature reference
35300view23:23, 11 February 2010NsalomonisModified description
21600view11:32, 14 November 2008MaintBot[[Pathway:Homo sapiens:EGFR1 NetPath 4]] moved to [[Pathway:WP437]]: Moved to stable identifier
7996view13:46, 7 January 2008MaintBot[[Pathway:Human:EGFR1 NetPath 4]] moved to [[Pathway:Homo sapiens:EGFR1 NetPath 4]]: Renaming species
7621view16:05, 18 December 2007MaintBotfixed category names
7215view12:33, 4 November 2007MaintBotAdded categories to GPML
6309view22:17, 22 May 2007A.Pandeygpml file for [[Human:EGFR1_NetPath_4]]

External references

DataNodes

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NameTypeDatabase referenceComment
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AKT1GeneProduct207 (Entrez Gene)
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ARAFGeneProduct369 (Entrez Gene)
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DOK2GeneProduct9046 (Entrez Gene)
DUSP1GeneProduct1843 (Entrez Gene)
EEF1A1GeneProduct1915 (Entrez Gene)
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KLF11GeneProduct8462 (Entrez Gene)
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SH2D3CGeneProduct10044 (Entrez Gene)
SH3BGRLGeneProduct6451 (Entrez Gene)
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SIN3AGeneProduct25942 (Entrez Gene)
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ZNF259GeneProduct8882 (Entrez Gene)

Annotated Interactions

No annotated interactions
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