Calcium regulation in cardiac cells (Rattus norvegicus)

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1Ca2+Protein Kinase CDAGgCalsequestrin S-CaGGNa+CaM kinaseP2+Cytosolic Ca2+PKA InhibitorsMembraneDepolarizationCalsequestrin C-CabgCaIP3PIP2IP4K+Ca2+GRKCytosolic CaK+2+Dihydropyridine-SensitiveM1 Muscarinic ReceptorCyclasesL-Type Ca2+ ChannelPKC inhibitor Protein-1bbgAdrenergic ReceptorFKBP12CaM kinaseK+Ca2+Epinephrine2+Regulators of G-proteinGap Junctions (Connexins)2+GG alpha i/o/zbgSignalingAdenylylADP + Piarrestin/GRKAdrenergic ReceptorcAMPPhopholambanNa+Calreticulin-CaPIP3 ReceptorsG alpha i/o/zarrestin/GRKIP3 ReceptorsRepolarizationGCalmodulin2+Na+/K+ ATPase2+b2+CaConnexinADP + PiNa+/Ca2+ Exchanger2+Protein Kinase AGNa2+2+CaCaAdenylyl CyclasesbSRCa2+Protein Kinase ACytosolic Ca2+ConnexinEpinephrineaCytosolbeta ArrestinCabPrkchLOC686059PRKAR1AGnai2Gnb1Atp1b2Gnao1PrkcdCasq1Gja5Cacna1eCamk2gGJA8Adcy4Chrm1Kcnb1YwhahAtp1b1PrkcbGjb3YWHAQItpr2Plcb3Atp2b3Rgs5PkiaCasq2Adra1aCALM1Cacnb3Gnb4Chrm3Rgs16Itpr3Prkar2aChrm2Adcy7YwhaeCamk4Atp1b3Adrb1Plcb3Camk1Fkbp1aRgs7Chrm4Camk2aAtp1a4ATPGnai3Gng8Gjd2Rgs1ADPGrk4SfnGrk5Fxyd2RYR3Gja4GJA7Rgs11Rgs3Slc8a1GNG4Rgs6Rgs2Gnb5Prkar1bAdra1bItpr1Gjb1Gngt1Kcnj5GNG2Gng12Gnai1GnaqGng11PrkchAdrb2Gng7Prkar2bPrkacbADCY9Adcy8GNASRgs19Gng13PkibCacna1dArrb2Gjb4Gnb2Camk2dAnxa6YwhagGjb2PrkcgSlc8a3YwhazPrkacaAdcy2Cacna1aRgs4Rgs14Camk2bPrkczPrkcaRgs18Rgs20Adcy3Chrm5Gjb5Adrb3Gng5ATPKcnj3GJA10Rgs10Adra1dGstt2CALM2Gja3ATPCACNA1SPLNAdcy5PkigRYR2CALM3Cacna1cATPAtp2a2Arrb1Gnb3Gjc2AcetylcholineGjb6YwhabAdcy6Cacnb1Atp2b2PrkceAtp2a3PrkcqAdcy1GnazPrkd1Gng3Atp2b1CalrGja1Rgs17Rgs9Cacna1bGrk6Gna11


Description

No description

Comments

HomologyConvert 
This pathway was inferred from Homo sapiens pathway WP536(r21808) with a 86% conversion rate.

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Quality Tags

Ontology Terms

 

Bibliography

  1. Marks AR; ''Calcium and the heart: a question of life and death.''; J Clin Invest, 2003 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
116945view10:04, 16 May 2021EweitzModified title
107238view14:33, 17 September 2019MaintBotChEBI identifier normalization
106978view13:43, 17 September 2019MaintBotHMDB identifier normalization
95760view14:13, 19 January 2018MkutmonHomology conversion update
72154view11:34, 25 October 2013EgonwAdded metabolite IDs.
71798view20:34, 17 October 2013MaintBotAutomated update of data sources
69427view19:03, 8 July 2013MaintBotUpdated to 2013 gpml schema
67773view13:57, 26 June 2013Christine ChichesterOntology Term : 'calcium/calcium-mediated signaling pathway' added !
47775view05:40, 6 April 2012Khanspersupdated xref
41751view02:40, 2 March 2011MaintBotRemoved redundant pathway information and comments
35446view11:42, 12 February 2010ThomasModified description
35444view11:41, 12 February 2010Thomasadded literature
34122view19:27, 9 December 2009MaintBotAutomatic update of empty xrefs
32400view17:02, 15 August 2009MaintBotFixed text labels
32051view13:31, 14 August 2009MaintBotFixed group labels
31432view21:02, 13 August 2009MaintBotFixed text labels
30986view00:54, 30 July 2009MaintBotConverted from Homo sapiens
21365view11:31, 14 November 2008MaintBot[[Pathway:Rattus norvegicus:Calcium regulation in cardiac cells]] moved to [[Pathway:WP326]]: Moved to stable identifier
7936view13:46, 7 January 2008MaintBot[[Pathway:Rat:Calcium regulation in cardiac cells]] moved to [[Pathway:Rattus norvegicus:Calcium regulation in cardiac cells]]: Renaming species
7593view16:02, 18 December 2007MaintBotfixed category names
7460view12:42, 4 November 2007MaintBotAdded categories to GPML
19395view22:19, 22 May 2007N.CotteUploaded from wpi.php
19394view22:19, 22 May 2007J.FongUploaded from wpi.php
6523view22:19, 22 May 2007NsalomonisUploaded from wpi.php

External references

DataNodes

View all...
NameTypeDatabase referenceComment
ADCY9GeneProduct302950 (Entrez Gene)
ADPMetabolite
ATPMetabolite
AcetylcholineMetabolite
Adcy1GeneProduct305509 (Entrez Gene) CYA1 HUMAN
Adcy2GeneProduct81636 (Entrez Gene) There is no SwissProt entry for a full-length sequence in mouse. This EST is from the Affymetrix Murine6500 chip.
Adcy3GeneProduct64508 (Entrez Gene)
Adcy4GeneProduct54223 (Entrez Gene) There is no SwissProt entry for a full-length sequence in mouse. This EST is from the Affymetrix Murine6500 chip.
Adcy5GeneProduct64532 (Entrez Gene) There is no SwissProt entry for a full-length sequence in mouse. This EST is from the Affymetrix Murine6500 chip.
Adcy6GeneProduct25289 (Entrez Gene)
Adcy7GeneProduct84420 (Entrez Gene)
Adcy8GeneProduct29241 (Entrez Gene)
Adra1aGeneProduct29412 (Entrez Gene)
Adra1bGeneProduct24173 (Entrez Gene)
Adra1dGeneProduct29413 (Entrez Gene)
Adrb1GeneProduct24925 (Entrez Gene)
Adrb2GeneProduct24176 (Entrez Gene)
Adrb3GeneProduct25645 (Entrez Gene)
Anxa6GeneProduct79125 (Entrez Gene)
Arrb1GeneProduct25387 (Entrez Gene)
Arrb2GeneProduct25388 (Entrez Gene)
Atp1a4GeneProduct29132 (Entrez Gene)
Atp1b1GeneProduct25650 (Entrez Gene)
Atp1b2GeneProduct24214 (Entrez Gene)
Atp1b3GeneProduct25390 (Entrez Gene)
Atp2a2GeneProduct29693 (Entrez Gene)
Atp2a3GeneProduct25391 (Entrez Gene)
Atp2b1GeneProduct29598 (Entrez Gene)
Atp2b2GeneProduct24215 (Entrez Gene)
Atp2b3GeneProduct29599 (Entrez Gene)
CACNA1SGeneProduct682930 (Entrez Gene)
CALM1GeneProduct24242 (Entrez Gene)
CALM2GeneProduct50663 (Entrez Gene)
CALM3GeneProduct24244 (Entrez Gene)
Cacna1aGeneProduct25398 (Entrez Gene)
Cacna1bGeneProduct257648 (Entrez Gene)
Cacna1cGeneProduct24239 (Entrez Gene)
Cacna1dGeneProduct29716 (Entrez Gene)
Cacna1eGeneProduct54234 (Entrez Gene)
Cacnb1GeneProduct50688 (Entrez Gene)
Cacnb3GeneProduct25297 (Entrez Gene)
CalrGeneProduct64202 (Entrez Gene)
Camk1GeneProduct171503 (Entrez Gene)
Camk2aGeneProduct25400 (Entrez Gene)
Camk2bGeneProduct24245 (Entrez Gene)
Camk2dGeneProduct24246 (Entrez Gene)
Camk2gGeneProduct171140 (Entrez Gene)
Camk4GeneProduct25050 (Entrez Gene)
Casq1GeneProduct686019 (Entrez Gene)
Casq2GeneProduct29209 (Entrez Gene)
Chrm1GeneProduct25229 (Entrez Gene)
Chrm2GeneProduct81645 (Entrez Gene)
Chrm3GeneProduct24260 (Entrez Gene)
Chrm4GeneProduct25111 (Entrez Gene)
Chrm5GeneProduct53949 (Entrez Gene)
Fkbp1aGeneProduct25639 (Entrez Gene)
Fxyd2GeneProduct29639 (Entrez Gene)
GJA10GeneProduct313126 (Entrez Gene)
GJA7GeneProduct266706 (Entrez Gene)
GJA8GeneProduct29601 (Entrez Gene)
GNASGeneProduct24896 (Entrez Gene)
GNG2GeneProduct80850 (Entrez Gene)
GNG4GeneProduct114118 (Entrez Gene)
Gja1GeneProduct24392 (Entrez Gene)
Gja3GeneProduct79217 (Entrez Gene)
Gja4GeneProduct25655 (Entrez Gene)
Gja5GeneProduct50563 (Entrez Gene)
Gjb1GeneProduct29584 (Entrez Gene)
Gjb2GeneProduct394266 (Entrez Gene)
Gjb3GeneProduct29585 (Entrez Gene)
Gjb4GeneProduct117055 (Entrez Gene)
Gjb5GeneProduct29586 (Entrez Gene)
Gjb6GeneProduct84403 (Entrez Gene)
Gjc2GeneProduct497913 (Entrez Gene)
Gjd2GeneProduct50564 (Entrez Gene)
Gna11GeneProduct81662 (Entrez Gene)
Gnai1GeneProduct25686 (Entrez Gene)
Gnai2GeneProduct81664 (Entrez Gene)
Gnai3GeneProduct25643 (Entrez Gene)
Gnao1GeneProduct50664 (Entrez Gene)
GnaqGeneProduct81666 (Entrez Gene)
GnazGeneProduct25740 (Entrez Gene)
Gnb1GeneProduct24400 (Entrez Gene)
Gnb2GeneProduct81667 (Entrez Gene)
Gnb3GeneProduct60449 (Entrez Gene)
Gnb4GeneProduct294962 (Entrez Gene)
Gnb5GeneProduct83579 (Entrez Gene)
Gng11GeneProduct64199 (Entrez Gene)
Gng12GeneProduct114120 (Entrez Gene)
Gng13GeneProduct685451 (Entrez Gene)
Gng3GeneProduct114117 (Entrez Gene)
Gng5GeneProduct79218 (Entrez Gene)
Gng7GeneProduct58979 (Entrez Gene)
Gng8GeneProduct245986 (Entrez Gene)
Gngt1GeneProduct680149 (Entrez Gene)
Grk4GeneProduct59077 (Entrez Gene)
Grk5GeneProduct59075 (Entrez Gene)
Grk6GeneProduct59076 (Entrez Gene)
Gstt2GeneProduct29487 (Entrez Gene)
Itpr1GeneProduct25262 (Entrez Gene)
Itpr2GeneProduct81678 (Entrez Gene)
Itpr3GeneProduct25679 (Entrez Gene)
Kcnb1GeneProduct25736 (Entrez Gene)
Kcnj3GeneProduct50599 (Entrez Gene)
Kcnj5GeneProduct29713 (Entrez Gene)
LOC686059GeneProduct686059 (Entrez Gene)
PLNGeneProduct64672 (Entrez Gene)
PRKAR1AGeneProduct25725 (Entrez Gene) KAP0 HUMAN
PkiaGeneProduct114906 (Entrez Gene)
PkibGeneProduct24678 (Entrez Gene)
PkigGeneProduct266709 (Entrez Gene)
Plcb3GeneProduct29322 (Entrez Gene)
PrkacaGeneProduct25636 (Entrez Gene)
PrkacbGeneProduct293508 (Entrez Gene)
Prkar1bGeneProduct25521 (Entrez Gene)
Prkar2aGeneProduct29699 (Entrez Gene)
Prkar2bGeneProduct24679 (Entrez Gene)
PrkcaGeneProduct24680 (Entrez Gene)
PrkcbGeneProduct25023 (Entrez Gene)
PrkcdGeneProduct170538 (Entrez Gene)
PrkceGeneProduct29340 (Entrez Gene) This EST is listed on the Affymetrix Murine6500 chip. The SwissProt entry name is KPCE MOUSE.
PrkcgGeneProduct24681 (Entrez Gene)
PrkchGeneProduct81749 (Entrez Gene)
PrkcqGeneProduct85420 (Entrez Gene)
PrkczGeneProduct25522 (Entrez Gene)
Prkd1GeneProduct85421 (Entrez Gene) KPCM HUMAN
RYR2GeneProduct689560 (Entrez Gene)
RYR3GeneProduct170546 (Entrez Gene)
Rgs10GeneProduct54290 (Entrez Gene)
Rgs11GeneProduct54291 (Entrez Gene)
Rgs14GeneProduct114705 (Entrez Gene)
Rgs1GeneProduct54289 (Entrez Gene)
Rgs16GeneProduct360857 (Entrez Gene)
Rgs17GeneProduct308118 (Entrez Gene)
Rgs18GeneProduct289076 (Entrez Gene)
Rgs19GeneProduct59293 (Entrez Gene)
Rgs20GeneProduct362477 (Entrez Gene)
Rgs2GeneProduct84583 (Entrez Gene)
Rgs3GeneProduct54293 (Entrez Gene)
Rgs4GeneProduct29480 (Entrez Gene)
Rgs5GeneProduct54294 (Entrez Gene)
Rgs6GeneProduct54295 (Entrez Gene)
Rgs7GeneProduct54296 (Entrez Gene)
Rgs9GeneProduct29481 (Entrez Gene)
SfnGeneProduct313017 (Entrez Gene)
Slc8a1GeneProduct29715 (Entrez Gene)
Slc8a3GeneProduct140448 (Entrez Gene)
YWHAQGeneProduct25577 (Entrez Gene)
YwhabGeneProduct56011 (Entrez Gene)
YwhaeGeneProduct29753 (Entrez Gene)
YwhagGeneProduct56010 (Entrez Gene)
YwhahGeneProduct25576 (Entrez Gene)
YwhazGeneProduct25578 (Entrez Gene) PMID: 9861170 PMID: 1317796

Annotated Interactions

No annotated interactions
Retrieved from "https://classic.wikipathways.org/index.php/Pathway:WP326"
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