Eicosanoid synthesis (Canis familiaris)

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16-Keto-Prostaglandin F2-alphaProstaglandin E215-Hydroperoxy Eicosatetraenoic Acid12-Hydroperoxy Eicosatetraenoic AcidCell MembraneThromboxane A3PLA2G6GGT115-HETELeukotriene E4PTGESPLA2G6Peroxidase?Leukotriene B4DPEP1Leukotriene C4Leukotriene A4ALOX5Prostaglandin D2Thromboxane A212-HETE5-HPETEPTGS1ALOX5APALOX15BPeroxidase?ALOX5APLeukotriene D4LTA4HPTGDSProstaglandin F2aLTC4SThromboxane B2Prostaglandin I2PTGS2TBXAS1ALOX12PTGES2PGE2 9-ketoreducPeroxidase?Arachidonic acidProstaglandin H2ALOX15ALOX5PGD2 11-ketoreducPNPLA8ALOX155-HETEPTGISPLA2G2A


Description

In biochemistry, eicosanoids are signaling molecules made by oxidation of twenty-carbon essential fatty acids, (EFAs). They exert complex control over many bodily systems, mainly in inflammation or immunity, and as messengers in the central nervous system. Source: Wikipedia

Comments

HomologyConvert 
This pathway was inferred from Homo sapiens pathway WP167(r21031) with a 70% conversion rate.

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Quality Tags

Ontology Terms

 

Bibliography

  1. Funk CD; ''''; , PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
117446view10:52, 21 May 2021EweitzModified title
106031view11:55, 16 August 2019MaintBotHMDB identifier normalization
89461view13:12, 15 September 2016Mkutmonremove space in ontology term id
71490view19:19, 17 October 2013MaintBotAutomated update of data sources
68599view23:25, 5 July 2013MaintBotUpdated to 2013 gpml schema
67182view10:17, 26 June 2013Christine ChichesterOntology Term : 'eicosanoid biosynthetic pathway' added !
62729view03:19, 2 May 2013MaintBotUpdated UniProt data source
40758view21:55, 1 March 2011MaintBotRemoved redundant pathway information and comments
35480view12:15, 12 February 2010Thomasadded literature
35475view12:13, 12 February 2010ThomasModified description
34030view18:48, 9 December 2009MaintBotAutomatic update of empty xrefs
31722view11:55, 14 August 2009MaintBotFixed group labels
30659view22:36, 29 July 2009MaintBotNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
12-HETEMetabolite
15-HETEMetabolite
5-HETEMetabolite
5-HPETEMetaboliteHMDB01193 (HMDB)
ALOX12GeneProduct479476 (Entrez Gene)
ALOX15GeneProduct489458 (Entrez Gene)
ALOX15BGeneProduct489485 (Entrez Gene)
ALOX5GeneProduct477753 (Entrez Gene)
ALOX5APGeneProduct477323 (Entrez Gene)
Arachidonic acidMetaboliteHMDB01043 (HMDB)
DPEP1GeneProduct479611 (Entrez Gene)
GGT1GeneProduct486400 (Entrez Gene)
LTA4HGeneProduct482611 (Entrez Gene)
LTC4SGeneProduct607316 (Entrez Gene)
Leukotriene A4MetaboliteHMDB01337 (HMDB)
Leukotriene B4MetaboliteHMDB01085 (HMDB)
Leukotriene C4MetaboliteHMDB01198 (HMDB)
Leukotriene D4MetaboliteHMDB03080 (HMDB)
Leukotriene E4MetaboliteHMDB02200 (HMDB)
PGD2 11-ketoreducGeneProduct
PGE2 9-ketoreducGeneProduct
PLA2G2AGeneProduct
PLA2G6GeneProduct481256 (Entrez Gene)
PNPLA8GeneProduct475880 (Entrez Gene)
PTGDSGeneProduct403740 (Entrez Gene)
PTGES2GeneProduct609101 (Entrez Gene)
PTGESGeneProduct480698 (Entrez Gene)
PTGISGeneProduct485919 (Entrez Gene)
PTGS1GeneProduct403544 (Entrez Gene)
PTGS2GeneProduct442942 (Entrez Gene)
Peroxidase?GeneProduct
Prostaglandin D2MetaboliteHMDB01403 (HMDB)
Prostaglandin F2aMetaboliteHMDB01139 (HMDB)
Prostaglandin H2MetaboliteHMDB01381 (HMDB)
Prostaglandin I2MetaboliteHMDB01335 (HMDB)
TBXAS1GeneProduct482771 (Entrez Gene)
Thromboxane A2MetaboliteHMDB01452 (HMDB)
Thromboxane B2MetaboliteHMDB03252 (HMDB)

Annotated Interactions

No annotated interactions
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