Eicosanoid synthesis (Bos taurus)

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115-Hydroperoxy Eicosatetraenoic AcidThromboxane A312-Hydroperoxy Eicosatetraenoic AcidCell Membrane6-Keto-Prostaglandin F2-alphaProstaglandin E2TBXAS1Peroxidase?Leukotriene C4LTA4HLTC4SProstaglandin F2aALOX15Leukotriene A4Prostaglandin D2PLA2G6PLA2G2AThromboxane A25-HPETEPGD2 11-ketoreduc5-HETEALOX12DPEP1ALOX5APALOX5PLA2G6Leukotriene B4Prostaglandin I2Peroxidase?PTGESProstaglandin H2PTGS2Arachidonic acidLeukotriene D4ALOX15BLeukotriene E4PTGS1PTGISPGE2 9-ketoreducPNPLA8PTGES212-HETEThromboxane B2ALOX5APALOX5PTGDSGGT1ALOX1515-HETEPeroxidase?


Description

In biochemistry, eicosanoids are signaling molecules made by oxidation of twenty-carbon essential fatty acids, (EFAs). They exert complex control over many bodily systems, mainly in inflammation or immunity, and as messengers in the central nervous system. Source: Wikipedia

Comments

HomologyConvert 
This pathway was inferred from Homo sapiens pathway WP167(r21031) with a 74% conversion rate.

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Ontology Terms

 

Bibliography

  1. Funk CD; ''Prostaglandins and leukotrienes: advances in eicosanoid biology.''; Science, 2001 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
117503view11:04, 21 May 2021EweitzModified title
105992view11:52, 16 August 2019MaintBotHMDB identifier normalization
89456view13:09, 15 September 2016Mkutmonremove space in ontology term id
80925view15:31, 30 June 2015Mkutmonhomology conversion
78598view14:51, 7 January 2015MaintBotadded missing graphIds
71397view19:00, 17 October 2013MaintBotAutomated update of data sources
67188view10:18, 26 June 2013Christine ChichesterOntology Term : 'eicosanoid biosynthetic pathway' added !
63319view21:06, 9 May 2013MaintBotUpdated to 2013 gpml schema
62701view23:16, 1 May 2013MaintBotUpdated UniProt data source
40500view19:28, 1 March 2011MaintBotRemoved redundant pathway information and comments
35481view12:15, 12 February 2010Thomasadded literature
35477view12:13, 12 February 2010ThomasModified description
33744view23:56, 8 December 2009MaintBotAutomatic update of empty xrefs
33620view10:02, 1 December 2009MaintBotRemoved group label
30541view21:56, 29 July 2009MaintBotNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
12-HETEMetabolite
15-HETEMetabolite
5-HETEMetabolite
5-HPETEMetaboliteHMDB01193 (HMDB)
ALOX12GeneProduct407169 (Entrez Gene)
ALOX15GeneProduct282139 (Entrez Gene)
ALOX15BGeneProduct286820 (Entrez Gene)
ALOX5GeneProduct404074 (Entrez Gene)
ALOX5APGeneProduct613869 (Entrez Gene)
Arachidonic acidMetaboliteHMDB01043 (HMDB)
DPEP1GeneProduct514685 (Entrez Gene)
GGT1GeneProduct615582 (Entrez Gene)
LTA4HGeneProduct507130 (Entrez Gene)
LTC4SGeneProduct511749 (Entrez Gene)
Leukotriene A4MetaboliteHMDB01337 (HMDB)
Leukotriene B4MetaboliteHMDB01085 (HMDB)
Leukotriene C4MetaboliteHMDB01198 (HMDB)
Leukotriene D4MetaboliteHMDB03080 (HMDB)
Leukotriene E4MetaboliteHMDB02200 (HMDB)
PGD2 11-ketoreducGeneProduct
PGE2 9-ketoreducGeneProduct
PLA2G2AGeneProduct521383 (Entrez Gene)
PLA2G6GeneProduct535381 (Entrez Gene)
PNPLA8GeneProduct535496 (Entrez Gene)
PTGDSGeneProduct286858 (Entrez Gene)
PTGES2GeneProduct493639 (Entrez Gene)
PTGESGeneProduct282019 (Entrez Gene)
PTGISGeneProduct282021 (Entrez Gene)
PTGS1GeneProduct282022 (Entrez Gene)
PTGS2GeneProduct282023 (Entrez Gene)
Peroxidase?GeneProduct
Prostaglandin D2MetaboliteHMDB01403 (HMDB)
Prostaglandin F2aMetaboliteHMDB01139 (HMDB)
Prostaglandin H2MetaboliteHMDB01381 (HMDB)
Prostaglandin I2MetaboliteHMDB01335 (HMDB)
TBXAS1GeneProduct509326 (Entrez Gene)
Thromboxane A2MetaboliteHMDB01452 (HMDB)
Thromboxane B2MetaboliteHMDB03252 (HMDB)

Annotated Interactions

No annotated interactions
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