Eukaryotic transcription initiation (Bos taurus)

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1, 2TFIIDRNA polymerase III5cell growthTATARNA polymerase II5TFIIF553(large ribosomal RNAs)TATA5TFIIHPrimary RNA transcript35dsDNASteps 5) RNA elongation with CDT phosphorylationTFIIA3Transcription Initiation Factors (TIFs)33Gene Regulatory ProteinsTATA3RNA polymerase ITFIIF55TATA Box bindingprotein3TFIID3TFIIHTFIIFSteps 3) DNA melting by association with TFIIH(recognize surface DNA geometry)5RNA pol IISteps 1) TBP binds TATA boxSteps 4) Transcription elongation by NTPs5TFIIBTFIIATFIIE(mRNA, snRNPs)TFIIESteps 2) Association of TIFs and RNA polymerase3(small stable RNAs)TFIIBPOLR1APOLR3HPOLR2ATAF6GTF2F2ERCC3ERCC2POLR2CGTF2E2ILKPOLR2IPOLR2GPOLR2FLOC615374GTF2H3POLR3BCCNHPOLR3EPOLR2KPOLR2HGTF2H2TAF7GTF2H1TBPCDK7POLR3DTAF9MNAT1GTF2A2POLR2EGTF2H4TAF12POLR2BPOLR2JPOLR3KTAF13TAF5POLR1BPOLR1DGTF2E1GTF2B


Description

In eukaryotes, RNA polymerase, and therefore the initiation of transcription, requires the presence of a core promoter sequence in the DNA. RNA polymerase is able to bind to core promoters in the presence of various specific transcription factors. The most common type of core promoter in eukaryotes is a short DNA sequence known as a TATA box. The TATA box, as a core promoter, is the binding site for a transcription factor known as TATA binding protein (TBP), which is itself a subunit of another transcription factor, called Transcription Factor II D (TFIID). After TFIID binds to the TATA box via the TBP, five more transcription factors and RNA polymerase combine around the TATA box in a series of stages to form a preinitiation complex. One transcription factor, DNA helicase, has helicase activity and so is involved in the separating of opposing strands of double-stranded DNA to provide access to a single-stranded DNA template. However, only a low, or basal, rate of transcription is driven by the preinitiation complex alone. Other proteins known as activators and repressors, along with any associated coactivators or corepressors, are responsible for modulating transcription rate. Source: Wikipedia

Comments

GenMAPP notes 
Reference: http://www.web-books.com/MoBio/Free/Ch4E.htm
HomologyConvert 
This pathway was inferred from Homo sapiens pathway WP405(r29565) with a 97% conversion rate.

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Bibliography

  1. Lemon B, Tjian R; ''Orchestrated response: a symphony of transcription factors for gene control.''; Genes Dev, 2000 PubMed Europe PMC Scholia
  2. Lee TI, Young RA; ''Regulation of gene expression by TBP-associated proteins.''; Genes Dev, 1998 PubMed Europe PMC Scholia

History

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CompareRevisionActionTimeUserComment
118352view13:31, 27 May 2021EweitzOntology Term : 'RNA polymerase I transcription initiation pathway' added !
118350view13:31, 27 May 2021EweitzOntology Term : 'RNA polymerase II transcription initiation pathway' added !
118349view13:30, 27 May 2021EweitzOntology Term : 'RNA polymerase III transcription initiation pathway' added !
117508view11:05, 21 May 2021EweitzModified title
80704view15:22, 30 June 2015Mkutmonhomology conversion
79155view05:06, 6 March 2015MaintBotUpdated conversion from Hs
67208view10:21, 26 June 2013Christine ChichesterOntology Term : 'transcription pathway' added !
63323view21:06, 9 May 2013MaintBotUpdated to 2013 gpml schema
48132view05:51, 9 May 2012MaintBotUpdating from human to fix xref duplication
40504view19:28, 1 March 2011MaintBotRemoved redundant pathway information and comments
35525view13:56, 12 February 2010Thomasadded literature
35512view13:49, 12 February 2010ThomasModified description
33747view23:57, 8 December 2009MaintBotAutomatic update of empty xrefs
32524view12:57, 17 August 2009MaintBotFixed text labels
32210view12:42, 15 August 2009MaintBotFixed text labels
31698view11:49, 14 August 2009MaintBotFixed group labels
31222view19:42, 13 August 2009MaintBotFixed text labels
30635view22:27, 29 July 2009MaintBotNew pathway

External references

DataNodes

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NameTypeDatabase referenceComment
CCNHGeneProduct615512 (Entrez Gene)
CDK7GeneProduct515462 (Entrez Gene)
ERCC2GeneProduct100125238 (Entrez Gene)
ERCC3GeneProduct507984 (Entrez Gene)
GTF2A2GeneProduct613479 (Entrez Gene)
GTF2BGeneProduct513231 (Entrez Gene)
GTF2E1GeneProduct540525 (Entrez Gene)
GTF2E2GeneProduct510921 (Entrez Gene)
GTF2F2GeneProduct509259 (Entrez Gene)
GTF2H1GeneProduct513510 (Entrez Gene)
GTF2H2GeneProduct511829 (Entrez Gene)
GTF2H3GeneProduct511896 (Entrez Gene)
GTF2H4GeneProduct100137723 (Entrez Gene)
ILKGeneProduct540207 (Entrez Gene)
LOC615374GeneProduct615374 (Entrez Gene)
MNAT1GeneProduct534176 (Entrez Gene)
POLR1AGeneProduct536316 (Entrez Gene)
POLR1BGeneProduct282342 (Entrez Gene)
POLR1DGeneProduct539061 (Entrez Gene)
POLR2AGeneProduct282312 (Entrez Gene)
POLR2BGeneProduct538184 (Entrez Gene)
POLR2CGeneProduct504452 (Entrez Gene)
POLR2EGeneProduct512971 (Entrez Gene)
POLR2FGeneProduct534232 (Entrez Gene)
POLR2GGeneProduct526320 (Entrez Gene)
POLR2HGeneProduct505599 (Entrez Gene)
POLR2IGeneProduct614472 (Entrez Gene)
POLR2JGeneProduct540428 (Entrez Gene)
POLR2KGeneProduct614776 (Entrez Gene)
POLR3BGeneProduct540839 (Entrez Gene)
POLR3DGeneProduct508049 (Entrez Gene)
POLR3EGeneProduct100140537 (Entrez Gene)
POLR3HGeneProduct767843 (Entrez Gene)
POLR3KGeneProduct618296 (Entrez Gene)
TAF12GeneProduct614227 (Entrez Gene)
TAF13GeneProduct513065 (Entrez Gene)
TAF5GeneProduct516001 (Entrez Gene)
TAF6GeneProduct505638 (Entrez Gene)
TAF7GeneProduct509327 (Entrez Gene)
TAF9GeneProduct532936 (Entrez Gene)
TBPGeneProduct516578 (Entrez Gene)

Annotated Interactions

No annotated interactions
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