Eukaryotic transcription initiation (Caenorhabditis elegans)

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1, 2TFIID3Primary RNA transcript35Gene Regulatory Proteins(recognize surface DNA geometry)333dsDNATFIIETATA5protein(small stable RNAs)5RNA polymerase I(large ribosomal RNAs)55Steps 1) TBP binds TATA boxTATA Box binding5TFIIH3RNA polymerase II(mRNA, snRNPs)TFIIASteps 5) RNA elongation with CDT phosphorylation5TATATFIIHTFIIB3TFIIB33TFIIFTFIIFTFIIASteps 4) Transcription elongation by NTPsTFIIF5Steps 3) DNA melting by association with TFIIH5TATAcell growthSteps 2) Association of TIFs and RNA polymeraseTranscription Initiation Factors (TIFs)TFIIERNA polymerase III5TFIIDRNA pol IImnat-1F09F7.3W01G7.3ZK550.4F14B4.3GTF2H4GTF2H3Y54E10BR.6cyh-1TAF12rpb-2POLR2Ktaf-13C36B1.3ttb-1R02D3.3POLR3EY66D12A.15H27M09.2Y50D7A.2tbp-1POLR3Dpat-4F54D5.11C06A1.5taf-6.1Y97E10AR.5Y48E1A.1Polr1eY111B2A.13cdk-7TAF9Y77E11A.6taf-7.2ZK856.10F26F4.11Y39B6A.36TAF5GTF2H2ama-1POLR1D


Description

In eukaryotes, RNA polymerase, and therefore the initiation of transcription, requires the presence of a core promoter sequence in the DNA. RNA polymerase is able to bind to core promoters in the presence of various specific transcription factors. The most common type of core promoter in eukaryotes is a short DNA sequence known as a TATA box. The TATA box, as a core promoter, is the binding site for a transcription factor known as TATA binding protein (TBP), which is itself a subunit of another transcription factor, called Transcription Factor II D (TFIID). After TFIID binds to the TATA box via the TBP, five more transcription factors and RNA polymerase combine around the TATA box in a series of stages to form a preinitiation complex. One transcription factor, DNA helicase, has helicase activity and so is involved in the separating of opposing strands of double-stranded DNA to provide access to a single-stranded DNA template. However, only a low, or basal, rate of transcription is driven by the preinitiation complex alone. Other proteins known as activators and repressors, along with any associated coactivators or corepressors, are responsible for modulating transcription rate. Source: Wikipedia

Comments

GenMAPP notes 
Reference: http://www.web-books.com/MoBio/Free/Ch4E.htm

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Bibliography

  1. Lee TI, Young RA; ''Regulation of gene expression by TBP-associated proteins.''; Genes Dev, 1998 PubMed Europe PMC Scholia
  2. Lemon B, Tjian R; ''Orchestrated response: a symphony of transcription factors for gene control.''; Genes Dev, 2000 PubMed Europe PMC Scholia

History

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CompareRevisionActionTimeUserComment
118093view10:53, 24 May 2021EweitzModified title
71438view19:06, 17 October 2013MaintBotAutomated update of data sources
68472view20:34, 5 July 2013MaintBotUpdated to 2013 gpml schema
67215view10:22, 26 June 2013Christine ChichesterOntology Term : 'transcription pathway' added !
40624view19:57, 1 March 2011MaintBotRemoved redundant pathway information and comments
35531view14:02, 12 February 2010Thomasadded literature
35520view13:53, 12 February 2010ThomasModified description
21768view11:32, 14 November 2008MaintBot[[Pathway:Caenorhabditis elegans:RNA transcription Reactome]] moved to [[Pathway:WP518]]: Moved to stable identifier
8501view14:00, 7 January 2008MaintBotAdded to category $category
8499view14:00, 7 January 2008NsalomonisUploaded new pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
C06A1.5GeneProduct174630 (Entrez Gene)
C36B1.3GeneProduct172680 (Entrez Gene)
F09F7.3GeneProduct175767 (Entrez Gene)
F14B4.3GeneProduct172752 (Entrez Gene)
F26F4.11GeneProduct175660 (Entrez Gene)
F54D5.11GeneProduct174765 (Entrez Gene)
GTF2H2GeneProduct
GTF2H3GeneProduct
GTF2H4GeneProduct
H27M09.2GeneProduct172412 (Entrez Gene)
POLR1DGeneProduct
POLR2KGeneProduct
POLR3DGeneProduct
POLR3EGeneProduct
Polr1eGeneProduct
R02D3.3GeneProduct176838 (Entrez Gene)
TAF12GeneProduct
TAF5GeneProduct
TAF9GeneProduct
W01G7.3GeneProduct175056 (Entrez Gene)
Y111B2A.13GeneProduct176682 (Entrez Gene)
Y39B6A.36GeneProduct180243 (Entrez Gene)
Y48E1A.1GeneProduct175015 (Entrez Gene)
Y50D7A.2GeneProduct175190 (Entrez Gene)
Y54E10BR.6GeneProduct171877 (Entrez Gene)
Y66D12A.15GeneProduct176584 (Entrez Gene)
Y77E11A.6GeneProduct176950 (Entrez Gene)
Y97E10AR.5GeneProduct179178 (Entrez Gene)
ZK550.4GeneProduct178502 (Entrez Gene)
ZK856.10GeneProduct179418 (Entrez Gene)
ama-1GeneProduct177190 (Entrez Gene)
cdk-7GeneProduct171784 (Entrez Gene)
cyh-1GeneProduct190078 (Entrez Gene)
mnat-1GeneProduct173602 (Entrez Gene)
pat-4GeneProduct175175 (Entrez Gene)
rpb-2GeneProduct175668 (Entrez Gene)
taf-13GeneProduct192052 (Entrez Gene)
taf-6.1GeneProduct173498 (Entrez Gene)
taf-7.2GeneProduct176686 (Entrez Gene)
tbp-1GeneProduct176054 (Entrez Gene)
ttb-1GeneProduct178544 (Entrez Gene)

Annotated Interactions

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