FAS pathway and stress induction of HSP regulation (Rattus norvegicus)
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DNA presentation
Cytoplasm
Stress Induction of HSP regulation
NFK-B Pathway
3x-P
Mitochondria Pathway
Self-activation
Stress
Nucleus
FAS Pathway
Apoptosis
Necrosis
Activate
Extracellular
ROS
Apoptosome
Cell Survival
Proteasome
3x-P
Cut
3x-P
Inhibition
Ceramide
Ripk2
Casp3
Map3k1
Phosphate
Casp9
Glutathione
actin
Fadd
Phosphate
Phosphate
Apaf1
Bcl2
Mapkapk3
Phosphate
Il1a
Spna2
Daxx
Hspb1
Dffb
Daxx
Map3k7
Hspb1
Mapk8
Apaf1
Hspb1
Hspb1
Dffb
Dffa
Cycs
Casp7
Phosphate
Tnf
Hspb1
Jun
Hspb1
Phosphate
Casp8
Lmnb1
Parp1
Phosphate
Arhgdib
CASP10
Faf1
Fas
Cflar
Pak1
Lmnb2
Lmna
Casp3
Mapkapk2
Casp6
Phosphate
Rb1
Hspb1
Prkdc
Gstt2
Casp8
Map2k4
Hspb1
Faslg
Faf1
Pak2
Description
This pathway describes the Fas induced apoptosis and interplay with Hsp27 in response to stress. More info:
BioCarta
.
Comments
GenMAPP remarks
Converted to human by GenMAPP.org.
HomologyConvert
This pathway was inferred from Homo sapiens pathway
WP314(r21341)
with a 94% conversion rate.
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Quality Tags
Ontology Terms
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Bibliography
Creagh EM, Sheehan D, Cotter TG; ''Heat shock proteins--modulators of apoptosis in tumour cells.''; Leukemia, 2000
PubMed
Europe PMC
Scholia
History
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Compare
Revision
Action
Time
User
Comment
116961
view
10:09, 16 May 2021
Eweitz
Modified title
109406
view
17:50, 16 March 2020
L Dupuis
Fixed interactions
109386
view
15:41, 16 March 2020
L Dupuis
Converted interactions to graphical lines
107008
view
13:46, 17 September 2019
MaintBot
HMDB identifier normalization
71788
view
20:32, 17 October 2013
MaintBot
Automated update of data sources
69391
view
18:58, 8 July 2013
MaintBot
Updated to 2013 gpml schema
67225
view
10:23, 26 June 2013
Christine Chichester
Ontology Term : 'FasL mediated signaling pathway' added !
47779
view
05:47, 6 April 2012
Khanspers
updated xref
41708
view
02:37, 2 March 2011
MaintBot
Removed redundant pathway information and comments
38245
view
21:23, 27 August 2010
Khanspers
Removed receptor and protein complex graphics
35564
view
15:04, 12 February 2010
Thomas
added literature
35559
view
15:01, 12 February 2010
Thomas
Modified description
34087
view
19:15, 9 December 2009
MaintBot
Automatic update of empty xrefs
33554
view
09:41, 1 December 2009
MaintBot
Removed group label
31581
view
22:02, 13 August 2009
MaintBot
Fixed text labels
30965
view
00:47, 30 July 2009
MaintBot
Converted from Homo sapiens
20869
view
11:30, 14 November 2008
MaintBot
[[Pathway:Rattus norvegicus:Fas Pathway and Stress Induction of HSP Regulation Biocarta]] moved to [[Pathway:WP89]]: Moved to stable identifier
8020
view
13:46, 7 January 2008
MaintBot
[[Pathway:Rat:Fas Pathway and Stress Induction of HSP Regulation Biocarta]] moved to [[Pathway:Rattus norvegicus:Fas Pathway and Stress Induction of HSP Regulation Biocarta]]: Renaming species
7633
view
16:06, 18 December 2007
MaintBot
fixed category names
7221
view
12:41, 4 November 2007
MaintBot
Added categories to GPML
6535
view
22:20, 22 May 2007
169.230.77.174
gpml file for [[Rat:Fas_Pathway_and_Stress_Induction_of_HSP_Regulation_Biocarta]]
External references
DataNodes
View all...
Name
Type
Database reference
Comment
Apaf1
GeneProduct
78963 (Entrez Gene)
Arhgdib
GeneProduct
362456 (Entrez Gene)
Interim Symbol: Arhgdib predicted and Name: Rho, GDP dissociation inhibitor (GDI) beta (predicted)
Bcl2
GeneProduct
24224 (Entrez Gene)
CASP10
GeneProduct
Casp3
GeneProduct
25402 (Entrez Gene)
Casp6
GeneProduct
83584 (Entrez Gene)
Casp7
GeneProduct
64026 (Entrez Gene)
Casp8
GeneProduct
64044 (Entrez Gene)
Casp9
GeneProduct
58918 (Entrez Gene)
Ceramide
Metabolite
Cflar
GeneProduct
117279 (Entrez Gene)
Cycs
GeneProduct
25309 (Entrez Gene)
Daxx
GeneProduct
140926 (Entrez Gene)
Dffa
GeneProduct
114214 (Entrez Gene)
Dffb
GeneProduct
84359 (Entrez Gene)
Fadd
GeneProduct
266610 (Entrez Gene)
Faf1
GeneProduct
140657 (Entrez Gene)
Fas
GeneProduct
246097 (Entrez Gene)
Faslg
GeneProduct
25385 (Entrez Gene)
Glutathione
Metabolite
HMDB00125 (HMDB)
Gstt2
GeneProduct
29487 (Entrez Gene)
Hspb1
GeneProduct
24471 (Entrez Gene)
Il1a
GeneProduct
24493 (Entrez Gene)
Jun
GeneProduct
24516 (Entrez Gene)
Lmna
GeneProduct
60374 (Entrez Gene)
Lmnb1
GeneProduct
116685 (Entrez Gene)
Lmnb2
GeneProduct
299625 (Entrez Gene)
Map2k4
GeneProduct
287398 (Entrez Gene)
Map3k1
GeneProduct
116667 (Entrez Gene)
Map3k7
GeneProduct
313121 (Entrez Gene)
Mapk8
GeneProduct
116554 (Entrez Gene)
Mapkapk2
GeneProduct
289014 (Entrez Gene)
Mapkapk3
GeneProduct
315994 (Entrez Gene)
Pak1
GeneProduct
29431 (Entrez Gene)
Pak2
GeneProduct
29432 (Entrez Gene)
Parp1
GeneProduct
25591 (Entrez Gene)
Phosphate
Metabolite
HMDB01429 (HMDB)
Prkdc
GeneProduct
360748 (Entrez Gene)
Rb1
GeneProduct
24708 (Entrez Gene)
Ripk2
GeneProduct
362491 (Entrez Gene)
receptor (TNFRSF)-interacting serine-threonine kinase 2
Spna2
GeneProduct
64159 (Entrez Gene)
Interim Symbol: Spna1 predicted and Name: spectrin alpha 1 (predicted)
Tnf
GeneProduct
24835 (Entrez Gene)
actin
GeneProduct
Annotated Interactions
No annotated interactions
Views
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Discussion
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DataNodes
Annotated Interactions
No annotated interactions