Integrin-mediated cell adhesion (Bos taurus)
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1
cell proliferation
ERK
ITGB
PAK
CAPN
PI3K
ITGA
CAPN
cell maintenance
signaling system
cell maintenance
F-actin
Phosphatidylinositiol
Integrin alpha
ECM
MEK
Integrin beta
p130 Cas
C3G
RAF
cell motility
PAK
F-actin
MAPK1
ITGB1
CAPN3
BRAF
LOC100138102
ITGAL
GRB2
ITGB4
MYLK2
DOCK1
ITGA9
RAF1
ITGA4
ITGB7
ITGB2
CAV2
ITGA3
CSK
BCAR1
PAK1
ITGB6
ITGA6
MAP2K2
CAV3
CAV1
ITGA10
MAPK10
PIK3R2
VCL
MAP2K1
SOS1
ITGAD
PAK3
ITGA1
TNS1
VAV2
ROCK1
PAK6
ITGAV
ITGB3
RAP1A
RHO
RAPGEF1
ITGA7
FYN
PTK2
PTK2
MAPK7
ITGAX
ITGA2B
RAC1
ACTN
PAK4
VASP
CDC42
ITGAM
ZYX
ITGA8
CAPN7
ARAF
CAPN1
SORBS1
ITGB8
SEPP1
ITGB5
SHC1
RAP1B
HRAS
ITGA5
MYO
SHC3
MAP2K6
ARHGEF7
CAPN10
ITGA2
PAK2
CAPN5
CAPNS1
AKT1
RAC2
ROCK2
CAPN2
CAPN11
ILK
MAPK12
MAP2K5
CAPN9
GIT2
MAP2K3
MAPK6
RAC3
LOC100137872
SRC
MAPK4
PI5K
TLN1
AKT2
MYO-P
CRK
ITGA11
p110
VAV3
PXN
LOC100140050
SRC
CAPN6
Description
No description
Comments
HomologyConvert
This pathway was inferred from Homo sapiens pathway
WP185(r21067)
with a 83% conversion rate.
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Quality Tags
Ontology Terms
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Bibliography
Hermeking H; ''The miR-34 family in cancer and apoptosis.''; Cell Death Differ, 2010
PubMed
Europe PMC
Scholia
Sepulveda JL, Gkretsi V, Wu C; ''Assembly and signaling of adhesion complexes.''; Curr Top Dev Biol, 2005
PubMed
Europe PMC
Scholia
History
View all...
Compare
Revision
Action
Time
User
Comment
117549
view
11:17, 21 May 2021
Eweitz
Modified title
80667
view
15:21, 30 June 2015
Mkutmon
homology conversion
71411
view
19:01, 17 October 2013
MaintBot
Automated update of data sources
67399
view
10:56, 26 June 2013
Ddigles
Ontology Term : 'integrin mediated signaling pathway' added !
63354
view
22:22, 9 May 2013
MaintBot
Updated to 2013 gpml schema
62704
view
23:17, 1 May 2013
MaintBot
Updated UniProt data source
40528
view
19:30, 1 March 2011
MaintBot
Removed redundant pathway information and comments
35601
view
15:45, 12 February 2010
Thomas
Modified description
35594
view
15:42, 12 February 2010
Thomas
added literature
33770
view
00:06, 9 December 2009
MaintBot
Automatic update of empty xrefs
31701
view
11:50, 14 August 2009
MaintBot
Fixed group labels
30638
view
22:28, 29 July 2009
MaintBot
New pathway
External references
DataNodes
View all...
Name
Type
Database reference
Comment
ACTN
GeneProduct
AKT1
GeneProduct
280991 (Entrez Gene)
AKT1; v-akt murine thymoma viral oncogene homolog 1 [EC:2.7.1.-]
AKT2
GeneProduct
534923 (Entrez Gene)
AKT2; v-akt murine thymoma viral oncogene homolog 2 [EC:2.7.1.-]
ARAF
GeneProduct
540421 (Entrez Gene)
ARAF1; v-raf murine sarcoma 3611 viral oncogene homolog 1 [EC:2.7.1.-]
ARHGEF7
GeneProduct
524352 (Entrez Gene)
ARHGEF7; Rho guanine nucleotide exchange factor (GEF) 7
BCAR1
GeneProduct
527550 (Entrez Gene)
BCAR1; breast cancer anti-estrogen resistance 1
BRAF
GeneProduct
536051 (Entrez Gene)
BRAF; v-raf murine sarcoma viral oncogene homolog B1 [EC:2.7.1.-]
CAPN10
GeneProduct
789674 (Entrez Gene)
CAPN10; calpain 10 [EC:3.4.22.17
CAPN11
GeneProduct
527966 (Entrez Gene)
CAPN11; calpain 11 [EC:3.4.22.17]
CAPN1
GeneProduct
281661 (Entrez Gene)
CAPN1; calpain 1 (mu/I) large subunit [EC:3.4.22.17]
CAPN2
GeneProduct
281662 (Entrez Gene)
CAPN2; calpain 2 (m/II) large subunit [EC:3.4.22.17]
CAPN3
GeneProduct
281663 (Entrez Gene)
CAPN3; calpain 3 (p94) [EC:3.4.22.17]
CAPN5
GeneProduct
536988 (Entrez Gene)
CAPN5; calpain
CAPN6
GeneProduct
539360 (Entrez Gene)
CAPN6; calpain 6 [EC:3.4.22.17]
CAPN7
GeneProduct
618048 (Entrez Gene)
CAPN7; calpain 7 [EC:3.4.22.17
CAPN9
GeneProduct
CAPN9; calpain 9 (nCL-4) [EC:3.4.22.17
CAPNS1
GeneProduct
281664 (Entrez Gene)
CAPNS1; calpain small subunit 1 [EC:3.4.22.17]
CAV1
GeneProduct
281040 (Entrez Gene)
CAV1; caveolin 1 caveolae protein 22kD
CAV2
GeneProduct
493642 (Entrez Gene)
CAV2; caveolin 2
CAV3
GeneProduct
615310 (Entrez Gene)
CAV3; caveolin 3
CDC42
GeneProduct
532712 (Entrez Gene)
CDC42; cell division cycle 42 (GTP binding protein 25kD)
CRK
GeneProduct
512841 (Entrez Gene)
CRK; v-crk sarcoma virus CT10 oncogene homolog (avian
CSK
GeneProduct
509246 (Entrez Gene)
CSK; c-src tyrosine kinase [EC:2.7.1.112]
DOCK1
GeneProduct
537203 (Entrez Gene)
DOCK1; dedicator of cyto-kinesis
FYN
GeneProduct
527263 (Entrez Gene)
FYN; FYN oncogene related to SRC FGR YES [EC:2.7.1.112]
GIT2
GeneProduct
516048 (Entrez Gene)
GIT2; G protein-coupled receptor kinase-interactor 2
GRB2
GeneProduct
535298 (Entrez Gene)
GRB2; growth factor receptor-bound protein 2
HRAS
GeneProduct
513012 (Entrez Gene)
ILK
GeneProduct
540207 (Entrez Gene)
ILK; integrin-linked kinase [EC:2.7.1.-]
ITGA10
GeneProduct
506526 (Entrez Gene)
ITGA11
GeneProduct
523755 (Entrez Gene)
ITGA1
GeneProduct
535951 (Entrez Gene)
ITGA2
GeneProduct
281872 (Entrez Gene)
ITGA2B
GeneProduct
515011 (Entrez Gene)
ITGA3
GeneProduct
508490 (Entrez Gene)
ITGA4
GeneProduct
282882 (Entrez Gene)
ITGA5
GeneProduct
281873 (Entrez Gene)
ITGA6
GeneProduct
535043 (Entrez Gene)
ITGA7
GeneProduct
506953 (Entrez Gene)
ITGA8
GeneProduct
ITGA9
GeneProduct
532127 (Entrez Gene)
ITGAD
GeneProduct
514056 (Entrez Gene)
ITGAL
GeneProduct
281874 (Entrez Gene)
ITGAM
GeneProduct
407124 (Entrez Gene)
ITGAV
GeneProduct
281875 (Entrez Gene)
ITGAX
GeneProduct
ITGB1
GeneProduct
281876 (Entrez Gene)
ITGB2
GeneProduct
281877 (Entrez Gene)
ITGB3
GeneProduct
282642 (Entrez Gene)
ITGB4
GeneProduct
506995 (Entrez Gene)
ITGB5
GeneProduct
282564 (Entrez Gene)
ITGB6
GeneProduct
282644 (Entrez Gene)
ITGB7
GeneProduct
514031 (Entrez Gene)
ITGB8
GeneProduct
536286 (Entrez Gene)
LOC100137872
GeneProduct
100137872 (Entrez Gene)
AKT3; v-akt murine thymoma viral oncogene homolog 3 (protein kinase B gamma) [EC:2.7.1.-]
LOC100138102
GeneProduct
100138102 (Entrez Gene)
PDPK1; 3-phosphoinositide dependent protein kinase-1 [EC:2.7.1.37]
LOC100140050
GeneProduct
100140050 (Entrez Gene)
MAP2K1
GeneProduct
533199 (Entrez Gene)
MAP2K1; mitogen-activated protein kinase kinase 1 [EC:2.7.1.-]
MAP2K2
GeneProduct
510434 (Entrez Gene)
MAP2K2; mitogen-activated protein kinase kinase 2 [EC:2.7.1.-]
MAP2K3
GeneProduct
516039 (Entrez Gene)
MAP2K3; mitogen-activated protein kinase kinase 3 [EC:2.7.1.-]
MAP2K5
GeneProduct
MAP2K5; mitogen-activated protein kinase kinase 5 [EC:2.7.1.-]
MAP2K6
GeneProduct
286883 (Entrez Gene)
MAP2K6; mitogen-activated protein kinase kinase 6 [EC:2.7.1.-
MAPK10
GeneProduct
537631 (Entrez Gene)
MAPK12
GeneProduct
512943 (Entrez Gene)
MAPK12; mitogen-activated protein kinase 12 [EC:2.7.1.-]
MAPK1
GeneProduct
327672 (Entrez Gene)
MAPK1; mitogen-activated protein kinase 1 [EC:2.7.1.-]
MAPK4
GeneProduct
529183 (Entrez Gene)
MAPK4; mitogen-activated protein kinase 4 [EC:2.7.1.-]
MAPK6
GeneProduct
538094 (Entrez Gene)
MAPK6; mitogen-activated protein kinase 6 [EC:2.7.1.-]
MAPK7
GeneProduct
537703 (Entrez Gene)
MAPK7; mitogen-activated protein kinase 7 [EC:2.7.1.-
MYLK2
GeneProduct
533378 (Entrez Gene)
MYLK2; myosin light chain kinase 2 skeletal muscle [EC:2.7.1.117
MYO-P
GeneProduct
MYO
GeneProduct
PAK1
GeneProduct
533729 (Entrez Gene)
PAK1; p21/Cdc42/Rac1-activated kinase 1 (STE20 homolog yeast) [EC:2.7.1.-]
PAK2
GeneProduct
PAK2; p21 (CDKN1A)-activated kinase 2 [EC:2.7.1.-]
PAK3
GeneProduct
534526 (Entrez Gene)
PAK3; p21 (CDKN1A)-activated kinase 3 [EC:2.7.1.-]
PAK4
GeneProduct
539742 (Entrez Gene)
PAK4; p21(CDKN1A)-activated kinase 4 [EC:2.7.1.-]
PAK6
GeneProduct
539224 (Entrez Gene)
PAK6; p21(CDKN1A)-activated kinase
PI5K
GeneProduct
PIK3R2
GeneProduct
282308 (Entrez Gene)
PIK3R2; phosphoinositide-3-kinase regulatory subunit polypeptide 2 (p85 beta)
PTK2
GeneProduct
506270 (Entrez Gene)
PTK2; PTK2 protein tyrosine kinase 2 [EC:2.7.1.112
PXN
GeneProduct
517456 (Entrez Gene)
PXN; paxillin
RAC1
GeneProduct
281440 (Entrez Gene)
RAC1; ras-related C3 botulinum toxin substrate 1 (rho family small GTP binding protein Rac1)
RAC2
GeneProduct
327671 (Entrez Gene)
RAC2; ras-related C3 botulinum toxin substrate 2 (rho family small GTP binding protein Rac2)
RAC3
GeneProduct
619066 (Entrez Gene)
RAC3; ras-related C3 botulinum toxin substrate 3 (rho family small GTP binding protein Rac3)
RAF1
GeneProduct
521196 (Entrez Gene)
RAF1; v-raf-1 murine leukemia viral oncogene homolog 1 [EC:2.7.1.-]
RAP1A
GeneProduct
282031 (Entrez Gene)
RAP1A; RAP1A member of RAS oncogene family
RAP1B
GeneProduct
327708 (Entrez Gene)
RAP1B; RAP1B member of RAS oncogene family
RAPGEF1
GeneProduct
520454 (Entrez Gene)
GRF2; guanine nucleotide-releasing factor 2 (specific for crk proto-oncogene
RHO
GeneProduct
509933 (Entrez Gene)
RHO; rhodopsin (opsin 2 rod pigment) (retinitis pigmentosa 4 autosomal dominant)
ROCK1
GeneProduct
785911 (Entrez Gene)
ROCK1; Rho-associated coiled-coil containing protein kinase
ROCK2
GeneProduct
282041 (Entrez Gene)
ROCK2; Rho-associated coiled-coil containing protein kinase
SEPP1
GeneProduct
282066 (Entrez Gene)
SEPP1; selenoprotein P plasma
SHC1
GeneProduct
507196 (Entrez Gene)
SHC1; SHC (Src homology 2 domain containing) transforming protein 1
SHC3
GeneProduct
512696 (Entrez Gene)
SHC3; neuronal Sh
SORBS1
GeneProduct
504625 (Entrez Gene)
SH3D5; SH3-domain protein 5 (ponsin
SOS1
GeneProduct
537682 (Entrez Gene)
SOS1; son of sevenless homolog 1 (Drosophila)
SRC
GeneProduct
535742 (Entrez Gene)
SRC; v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian) [EC:2.7.1.112]
TLN1
GeneProduct
783470 (Entrez Gene)
TLN1; talin 1
TNS1
GeneProduct
286798 (Entrez Gene)
TNS; tensi
VASP
GeneProduct
514902 (Entrez Gene)
VASP; vasodilator-stimulated phosphoprotein
VAV2
GeneProduct
VAV2; vav 2 oncogene
VAV3
GeneProduct
521961 (Entrez Gene)
VAV3; vav 3 oncogene
VCL
GeneProduct
783645 (Entrez Gene)
VCL; vinculin
ZYX
GeneProduct
768226 (Entrez Gene)
ZYX; zyxin
p110
GeneProduct
Annotated Interactions
No annotated interactions
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Try the New WikiPathways
View approved pathways at the new wikipathways.org.Quality Tags
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Bibliography
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External references
DataNodes
Annotated Interactions
No annotated interactions