Androgen receptor signaling pathway (Canis familiaris)

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1-7MitochondrionMTExtracellularProteolytic CleavageEndoplasmic reticulumCY->NUAccession Number: NetPath 2; cellmap:2NucleusCY->NUPDCytoplasmSumoylationPControlDTranslocationReceptorMolecular associationDDLigandPhosphorylationDemethylationMethylationAutophosphorylationCY->NUActivationDEnzyme complexDeubiquitinationDeacetylationProteins in a complex interactionAndrogen IndependentCYDephosphorylationGlycosylationPalmitoylationGOAcetylationNUGolgi appparatusPECInhibitionPPMENPlasma membraneDeSumoylationEndosome(Protein-protein interaction)UbiquitinationReactions through unknown mechanisms/moleculesERMolecule in the pathwayCY->NUAndrogen IndependentRecruitmentGene SymbolPAndrogen (T/DHT)UBE2INCOA4CASP8NR3C1CREBBPESR1NCOR2SVILMAPK1GAPDHNCOA1ARCCNHFLNACASP7STAT3GTF2H1NR3C1MDM2NR2C2NCOA2RNF4HMGB1ARETV5CDC2CAV1CTNNB1TP53SRCPNRC1PIAS4AESCDK7JUNLOC491072RUNX2NR0B1SMAD3RNF14PATZ1CCNE1BAG1HMGB2STUB1GTF2F1RB1SIN3ACALRRUNX1RCHY1PSMC3IPPNRC1MMP1KAT5TGFB1I1IL6STAPPL1PIAS3GTF2F2NCOA3ATF2SENP1CASP1UXTKAT2BHSPA1APOU2F1SP1PTENBRCA1SRYRCHY1RAD54L2MAPK1MAP2K1CCND1PRMT1PLAGL1SPDEFIGF1RASCTDP1RAF1TMF1ARPIAS2EGFRCASP3SLC25A4PA2G4GHRFLNACDC25BPXNNR0B2UBE3ACOX5BNSD1RAC3YWHAHNR5A1AKT1CDC37ARNRIP1ARESR1SMAD4PRMT1IL6RB1ESR2PAK6RANHIPK3LOC487309FHL2TGIFRELARHOXF2AKT1PIAS1JUNEP300CDK9RANBP9POU2F2


Description

The androgen receptor is a member of the nuclear receptor family of ligand activated transcription factors. These receptors bind to steroid hormones, thyroid hormone, retinoids and vitamin D among others, dimerize and bind to DNA. Its ligands include testosterone, dehydroepiandrosterone and androstenedione. Stimulation of the receptor activates the SMAD signaling module. Source: http://www.netpath.org/pathways?path_id=NetPath_2

Comments

GenMAPP notes 
NetPath:2; cellmap:2 - Androgen Receptor Signaling Pathway. The Androgen Receptor signaling pathway was kindly reviewed by Liying Zhang and William Gerald. This cancer signaling pathway is available at Cancer Cell Map (http://cancer.cellmap.org) and NetPath (http://www.netpath.org) and is part of a collaborative project between the Computational Biology Center at Memorial Sloan-Kettering Cancer Center (http://cbio.mskcc.org), PandeyLab at Johns Hopkins University (http://pandeylab.igm.jhmi.edu) and Institute of Bioinformatics (http://www.ibioinformatics.org). If you use this pathway, you must cite the Cancer Cell Map and NetPath websites until the pathway is published.
GenMAPP remarks 
http://cancer.cellmap.org; http://www.netpath.org
HomologyConvert 
This pathway was inferred from Homo sapiens pathway WP138(r20973) with a 90% conversion rate.

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Bibliography

  1. Kandasamy K, Mohan SS, Raju R, Keerthikumar S, Kumar GS, Venugopal AK, Telikicherla D, Navarro JD, Mathivanan S, Pecquet C, Gollapudi SK, Tattikota SG, Mohan S, Padhukasahasram H, Subbannayya Y, Goel R, Jacob HK, Zhong J, Sekhar R, Nanjappa V, Balakrishnan L, Subbaiah R, Ramachandra YL, Rahiman BA, Prasad TS, Lin JX, Houtman JC, Desiderio S, Renauld JC, Constantinescu SN, Ohara O, Hirano T, Kubo M, Singh S, Khatri P, Draghici S, Bader GD, Sander C, Leonard WJ, Pandey A; ''NetPath: a public resource of curated signal transduction pathways.''; Genome Biol, 2010 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
115921view17:01, 20 March 2021EgonwCopied the NetPath paper into the literature list
115916view15:31, 20 March 2021EgonwModified description
78442view10:26, 7 January 2015MaintBotadded missing graphIds
71482view19:18, 17 October 2013MaintBotAutomated update of data sources
68580view23:07, 5 July 2013MaintBotUpdated to 2013 gpml schema
67042view09:58, 26 June 2013Christine ChichesterOntology Term : 'androgen signaling pathway' added !
48158view18:53, 9 May 2012MaintBotUpdating from human to fix xrefs
40739view21:53, 1 March 2011MaintBotRemoved redundant pathway information and comments
35691view22:59, 12 February 2010AlexanderPico
35689view22:57, 12 February 2010AlexanderPicoadding description and refs
34014view18:43, 9 December 2009MaintBotAutomatic update of empty xrefs
32564view13:10, 17 August 2009MaintBotFixed text labels
31262view19:55, 13 August 2009MaintBotFixed text labels
30702view22:50, 29 July 2009MaintBotNew pathway

External references

DataNodes

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NameTypeDatabase referenceComment
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AKT1GeneProduct490878 (Entrez Gene)
APPL1GeneProduct484716 (Entrez Gene)
ARGeneProduct403588 (Entrez Gene)
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BAG1GeneProduct611781 (Entrez Gene)
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EP300GeneProduct
ESR1GeneProduct403640 (Entrez Gene)
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ETV5GeneProduct607474 (Entrez Gene)
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FLNAGeneProduct481084 (Entrez Gene)
GAPDHGeneProduct403755 (Entrez Gene)
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GTF2F1GeneProduct476731 (Entrez Gene)
GTF2F2GeneProduct609164 (Entrez Gene)
GTF2H1GeneProduct476881 (Entrez Gene)
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HMGB1GeneProduct403170 (Entrez Gene)
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KAT2BGeneProduct477052 (Entrez Gene)
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PATZ1GeneProduct486365 (Entrez Gene)
PIAS1GeneProduct478350 (Entrez Gene)
PIAS2GeneProduct480147 (Entrez Gene)
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RAC3GeneProduct
RAD54L2GeneProduct476608 (Entrez Gene)
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RHOXF2GeneProduct611154 (Entrez Gene)
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SIN3AGeneProduct478372 (Entrez Gene)
SLC25A4GeneProduct475630 (Entrez Gene)
SMAD3GeneProduct610902 (Entrez Gene)
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SP1GeneProduct486507 (Entrez Gene)
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SRCGeneProduct485864 (Entrez Gene)
SRYGeneProduct
STAT3GeneProduct490967 (Entrez Gene)
STUB1GeneProduct479892 (Entrez Gene)
SVILGeneProduct477965 (Entrez Gene)
TGFB1I1GeneProduct489932 (Entrez Gene)
TGIFGeneProduct
TMF1GeneProduct476561 (Entrez Gene)
TP53GeneProduct403869 (Entrez Gene)
UBE2IGeneProduct491332 (Entrez Gene)
UBE3AGeneProduct479010 (Entrez Gene)
UXTGeneProduct480900 (Entrez Gene)
YWHAHGeneProduct

Annotated Interactions

No annotated interactions
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