EGF/EGFR signaling (Homo sapiens)

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1CYAutodephosphorylationNUCYCYMAPlasma membraneMANUNUPMCY(Protein-protein interaction)NUCYPMMACYEnzyme complexPMAccession Number : NetPath 4; cellmap:4CYCYPMPMGlycosylationMolecule in the pathwayMTENCYPMPMMAMolecular associationPMPMMACYPhosphorylationDemethylationPMPMCYNUCYCYCYDeubiquitinationMAControlPMProteins in a complex interactionNUCYPMMAPMDAcetylationPMActivationECNUNUMANUMAMethylationPMCYTranslocationCYRecruitmentNUMAMAEndosomeLigandProteolytic cleavageCYDeacetylationMANUCYMANucleusDesumoylationCYCYCYENMADNUMAReceptorNUReaction through unknown mechanisms/moleculesCYGolgi apparatusGOMitochondrionSumoylationCYNUDephosphorylationMANUPalmitoylationPMENPMMANUCytoplasmPMUbiquitinationEndoplasmic reticulumCYGene SymbolMAPMCYNUMAPMMAInhibitionCYMACYCYCYCYNUCYAutophosphorylationCYCYNUExtracellularDPMNUERCYKLF11ELK1EGFRPRKAR1AEPPK1PIK3CBKRT8CRKLATF1CEBPBELF3PIK3CGRPS6KA2SNRPD2STAT2PLCG2PIK3R2GAB2PRKCZHAT1TNIP1SH3GL3JAK1RIPK1WASLSH3GL2CREB1CBLBMAP2K1ARF4PLCG1PAK1DUSP1STXBP1APPLSTAT5AEGFMAPK1SPRY2ZNF259SH3BGRLEGFRRBBP7SOS1KRT18RPS6KA3STAT2PIK3CAPTPN11EGFSTAT1PLCG1PIK3R3HIP1PLEC1TNK2RPS6KA3ABI1PRKCIGAB1KRAS2EPS15AP2A1RGS16SMAD2PLSCR1VAV3BCAR1DIP13BSPRY2RPS6KA5HRASMAP2K7RASA1CSKBCAR1MAP2K2PKN2PRKCB1EGFRPIK3R1JAK2RALGDSPLCG2PRKCASIN3AMAP3K4GAB1SHC1PXNVAV2TGIFSTAT5BCDC42HIST3H3PTPN5NRASMAPK8STAT3ITCHSOCS1AKT1GIT1DNM1STAT3PRKCAMAPK3RPS6KA1RFXANKWNK1JUNSHOC2DOK2MYCSTAT5AEGFEEF1A1PRKCGRAC1SMAD3FOSMAP2K1HDAC1EEF1A1PTPN6GJA1SMAD3RAF1PTK6RAF1ARF4PTPN12MAP3K3CBLMAP2K3RALBPLD2RALBP1SMAD2CASP9USP6NLMTA2GRB2CAMK2ASTAT1GRB10CAV1ELK4DUSP1NCK2MAPK7YWHABNDUFA13ELF3EGFRMAPK14MAPK1DIP13BARAFKRT17EPN1PRKCMFOXO1ACRKCAV2GRB14REPS2CEBPAKRT7VAV1ARF4ERRFI1RAB5APLD1PTK2BSTAT3DDEF1INPPL1STXBP1PTPN6SP1MAP3K2MCF2ZNF259GRB7PIK3C2BFOXO1ASH2D3CSOCS3CTNND1STAT1SRCJUNDREPS1MAP3K14CEACAM1EPS15APPLSH3GL2PTPRRSH3KBP1PIK3CDMAP3K1PEBP1PLD1EPS8EPS15L1MAP3K2CBLCSOS2SH2D3CMAP2K5SNCASHC1HDAPPLNCK1PITPNA


Description

The androgen receptor is a member of the nuclear receptor family of ligand activated transcription factors. These receptors bind to steroid hormones, thyroid hormone, retinoids and vitamin D among others, dimerize and bind to DNA. Its ligands include testosterone, dehydroepiandrosterone and androstenedione. Stimulation of the receptor activates the SMAD signaling module. Source: http://www.netpath.org/pathways?path_id=NetPath_4

Comments

GenMAPP notes 
NetPath 4; cellmap:4 - EGFR1 Signaling Pathway.This cancer signaling pathway is available at Cancer Cell Map (http://cancer.cellmap.org) and NetPath (http://www.netpath.org) and is part of a collaborative project between the Computational Biology Center at Memorial Sloan-Kettering Cancer Center (http://cbio.mskcc.org), PandeyLab at Johns Hopkins University (http://pandeylab.igm.jhmi.edu) and Institute of Bioinformatics (http://www.ibioinformatics.org). If you use this pathway, you must cite the Cancer Cell Map and NetPath websites until the pathway is published.
GenMAPP remarks 
http://cancer.cellmap.org; http://www.netpath.org

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Bibliography

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History

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CompareRevisionActionTimeUserComment
129679view00:46, 22 May 2024EweitzModified title
126309view17:28, 20 April 2023EgonwLicense is CCZero
120689view12:47, 23 December 2021EweitzStandardize font, weight, case
118995view09:26, 8 June 2021FinterlyRemoved empty Comment
116546view12:14, 7 May 2021EweitzModified title
115923view20:35, 20 March 2021EgonwModified description
111019view14:22, 30 June 2020L DupuisConverted interaction lines in legend to graphical lines
106392view21:27, 28 August 2019KhanspersModified description
105574view06:29, 9 August 2019KhanspersModified description
79266view20:32, 19 March 2015ZariChenged Identifier for PXN
78502view10:29, 7 January 2015MaintBotadded missing graphIds
72106view22:03, 24 October 2013AlexanderPicoadded xrefs
71357view18:35, 17 October 2013MaintBotAutomated update of data sources
70625view21:22, 16 August 2013MaintBotUpdated xrefs from Anatoly Urisman
67174view10:16, 26 June 2013Christine ChichesterOntology Term : 'epidermal growth factor/neuregulin signaling pathway' added !
63177view20:30, 8 May 2013MaintBotUpdating gpml version
47973view14:23, 23 April 2012NetPathModified description
44600view21:09, 21 September 2011KhanspersUpdating content to NetSlim
44120view20:50, 24 August 2011KhanspersReverted to version '23:15, 1 March 2011' by Khanspers
44017view22:41, 22 August 2011Khanspers
44009view22:10, 22 August 2011KhanspersModified description
44008view22:05, 22 August 2011KhanspersModified description
44007view22:03, 22 August 2011KhanspersModified description
44006view22:00, 22 August 2011KhanspersUpdating pathway from NetSlim
41034view23:15, 1 March 2011MaintBotRemoved redundant pathway information and comments
35716view23:27, 12 February 2010AlexanderPico
35432view11:23, 12 February 2010MichielChanged literature reference
35428view11:06, 12 February 2010MichielAdded literature reference
35300view23:23, 11 February 2010NsalomonisModified description
21600view11:32, 14 November 2008MaintBot[[Pathway:Homo sapiens:EGFR1 NetPath 4]] moved to [[Pathway:WP437]]: Moved to stable identifier
7996view13:46, 7 January 2008MaintBot[[Pathway:Human:EGFR1 NetPath 4]] moved to [[Pathway:Homo sapiens:EGFR1 NetPath 4]]: Renaming species
7621view16:05, 18 December 2007MaintBotfixed category names
7215view12:33, 4 November 2007MaintBotAdded categories to GPML
6309view22:17, 22 May 2007A.Pandeygpml file for [[Human:EGFR1_NetPath_4]]

External references

DataNodes

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NameTypeDatabase referenceComment
ABI1GeneProduct10006 (Entrez Gene)
AKT1GeneProduct207 (Entrez Gene)
AP2A1GeneProduct160 (Entrez Gene)
APPLGeneProduct26060 (Entrez Gene)
ARAFGeneProduct369 (Entrez Gene)
ARF4GeneProduct378 (Entrez Gene)
ATF1GeneProduct466 (Entrez Gene)
BCAR1GeneProduct9564 (Entrez Gene)
CAMK2AGeneProduct815 (Entrez Gene)
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DNM1GeneProduct1759 (Entrez Gene)
DOK2GeneProduct9046 (Entrez Gene)
DUSP1GeneProduct1843 (Entrez Gene)
EEF1A1GeneProduct1915 (Entrez Gene)
EGFGeneProduct1950 (Entrez Gene)
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INPPL1GeneProduct3636 (Entrez Gene)
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KLF11GeneProduct8462 (Entrez Gene)
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PTK2BGeneProduct2185 (Entrez Gene)
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RAC1GeneProduct5879 (Entrez Gene)
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RALBGeneProduct5899 (Entrez Gene)
RALBP1GeneProduct10928 (Entrez Gene)
RALGDSGeneProduct5900 (Entrez Gene)
RASA1GeneProduct5921 (Entrez Gene)
RBBP7GeneProduct5931 (Entrez Gene)
REPS1GeneProduct85021 (Entrez Gene)
REPS2GeneProduct9185 (Entrez Gene)
RFXANKGeneProduct8625 (Entrez Gene)
RGS16GeneProduct6004 (Entrez Gene)
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RPS6KA5GeneProduct9252 (Entrez Gene)
SH2D3CGeneProduct10044 (Entrez Gene)
SH3BGRLGeneProduct6451 (Entrez Gene)
SH3GL2GeneProduct6456 (Entrez Gene)
SH3GL3GeneProduct6457 (Entrez Gene)
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SHC1GeneProduct6464 (Entrez Gene)
SHOC2GeneProduct8036 (Entrez Gene)
SIN3AGeneProduct25942 (Entrez Gene)
SMAD2GeneProduct4087 (Entrez Gene)
SMAD3GeneProduct4088 (Entrez Gene)
SNCAGeneProduct6622 (Entrez Gene)
SNRPD2GeneProduct6633 (Entrez Gene)
SOCS1GeneProduct8651 (Entrez Gene)
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SOS2GeneProduct6655 (Entrez Gene)
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TNK2GeneProduct10188 (Entrez Gene)
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VAV1GeneProduct7409 (Entrez Gene)
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WASLGeneProduct8976 (Entrez Gene)
WNK1GeneProduct65125 (Entrez Gene)
YWHABGeneProduct7529 (Entrez Gene)
ZNF259GeneProduct8882 (Entrez Gene)

Annotated Interactions

No annotated interactions
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