HG_Shared_Pathway-MYCN-NOTCH-ALK (Homo sapiens)

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1CENP-A/I/MApoptosisG2MembraneNucleus?MSG1CentrosomeCPCMotilityCCNB1/2AURKBRB1RASCDKN2A (p16)PMSX1TCF4NOTCH3-ICCDKN1B (p27)CDKN1C (p57)MYCNPHOX2BTACC2PBOREALINASCL1ERKHEY1FOXO3CCNA1/2PCCNG2CDK4/6SURVIVINAKTCDK1PCDK2LIN28BBMP4CDCA3 (TOME1)TP53CDKN1A (p21)PIK3R1PIK3CACCND1CDK2CCNE1/2MEKESCO2FOXR1PFOXO3Pre-RCNF1DLL3JAG1ALKBMPR2NOTCH3PPP


Description

Reflects the current status of research in the Human Genetics Department of the AMC in Amsterdam.

This is confidential. The pathway organizes results from wet lab experiments in the IMR32 neuroblastoma cell line.

Readouts are from Affymetrix array, western blot

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Quality Tags

Ontology Terms

 

Bibliography


History

View all...
CompareRevisionActionTimeUserComment
36584view11:37, 6 April 2010PietDeleted pathway: Temporary subselection
36540view09:24, 30 March 2010PietPeriodical save, work in progress
36539view09:08, 30 March 2010Pietcoloring for version 1
36538view09:03, 30 March 2010PietPeriodical save, work in progress
36537view08:52, 30 March 2010PietNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
AKTGeneProduct208 (Entrez Gene)
ASCL1GeneProduct
AURKBGeneProduct
BMP4GeneProduct
BOREALINGeneProduct
CCNA1/2GeneProduct
CCNB1/2GeneProduct
CCND1GeneProduct
CCNE1/2GeneProduct
CCNG2GeneProduct
CDCA3 (TOME1)GeneProduct
CDK1GeneProduct
CDK2GeneProduct1017 (Entrez Gene)
CDK4/6GeneProduct
CDKN1A (p21)GeneProduct
CDKN1B (p27)GeneProduct
CDKN1C (p57)GeneProduct1786 (Entrez Gene) 38 Genes additionally regulated
CDKN2A (p16)GeneProduct
ERKGeneProduct5595 (Entrez Gene) ERK
ESCO2GeneProduct
FOXO3GeneProduct2309 (Entrez Gene)
FOXR1GeneProduct
HEY1GeneProduct
LIN28BGeneProduct
MEKGeneProduct4214 (Entrez Gene) MEK
MSX1GeneProduct4487 (Entrez Gene)
MYCNGeneProduct4613 (Entrez Gene)
NF1GeneProduct4763 (Entrez Gene)
NOTCH3-ICGeneProduct4854 (Entrez Gene)
PMetabolite
PHOX2BGeneProduct8929 (Entrez Gene)
PIK3CAGeneProduct5290 (Entrez Gene) Alias p110
PIK3R1GeneProduct5295 (Entrez Gene) Alias p85a
Pre-RCGeneProduct
RASGeneProduct4893 (Entrez Gene) And other RAS proteins?
RB1GeneProduct5925 (Entrez Gene)
SURVIVINGeneProduct
TACC2GeneProduct
TCF4GeneProduct
TP53GeneProduct

Annotated Interactions

No annotated interactions

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