DIV (Homo sapiens)

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7CACNG3CACNB3FGFR4LOW=BAD PRPDGFRAFGF9PRKXFGF19EXPR NO PRE47LOW=MOD BAD PRMAPKAPK3CACNA2D3DUSP16FLNBMAP3K2FLNCHIGH=BAD PRCACNA2D2HIGH=MOD BAD PRRAPGEF2p53 signaling pathwayPTPWnt signaling pathwayJNKLPSDNA damageCa2+DAGERK5 pathwayApoptosisMAPKKKKPhosphatidylinositolsignaling systemSerum, cytotoxic drugs, irradiation,heatshock, reactive oxy speciesLPS and other stressProliferation, differentiationDNADNAPTPMAPKKp38Proliferation, differentiationProliferation, inflammation, anti-apoptosisCellDNADNADNAMAPKMAPKKKJNK & p38 MAP kinase pathwayHeteromeric G-proteinCycleTranscription factorsClassical MAP kinase PathwayProliferation, differentiation,inflammationMKPSerum, EGF,reactive oxygen species.or Srk tyrokinase downstreamIP3MAPK8IP3MAP3K5ARRB2NF1CASP2PLA2G5MAP2K5MAPKAPK5TGFB3MAP3K13MAP3K11DUSP7MAPTMAP3K3FOSCASP7NRASRPS6KA3sap1aHSPA8cAMPATF4TRAF2MYCTRAF6ATF4MAP2K1KRASPTPN5CASP6PPP3R2IL1R1MAP2K4DUSP6ATF2DUSP10PRKCHTGFB2TMEM37SOS2PPP5CMAPK3IL1AFLNAMOSMAP3K8CDC25Belk-1HSPA5MAP4K4MAXPRKACADDIT3BDNFCDC42FGF4NFKB1NTF5RAC1DUSP4TAOK1MAPK4ELK4/Sap1aGRB2NLKCASP9DUSP1STMN1MAPK13CRKELK1PTPN7HSPB1MAPK1MAP3K7IP2PTPN7MAP3K12STK3CD14RAC2PRKCGPDGFBCASP3mkk3RASGRP4MAP2K2PPP3CBMAP2K6MAPK14AKT2BRAFPLA2G10MAP3K14TNFFASGCKNTRK1HSPA1ARAF1FASLGIKBKBMAPK8MAP2K1IP1TAOK2MAP3K4MAPK6RASGRF2MAP3K7IP1MAPK7HSPB2GNA12IL1R2CASP1RAP1BMEF2CGADD45APPP3CCPTPRRPDGFRBMAP4K1MAP3K1RASA2PPM1APTPRRmsk1/2MAPK9DAXXECSITSRFEGFRRAP1APAK1PPP3R1PRKCDnfat2/4AKT1RASA1CRKLMAP3K6TP53MAP3K7mnk1/2MAP4K3PRKCB1NGFBMAP2K7MAPKAPK2MRASARRB1RASGRP1IL1BMAPK12PPP3CACASP8ZAKDUSP5PTPN5PPM1BfgfrPRKCDMAPK10NR4A1JUNDEGFTGFB1MINK1AKT3PRKCZIKBKGJUNPAK2


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Bibliography


History

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CompareRevisionActionTimeUserComment
40450view15:04, 28 February 2011AmcuserDeleted pathway: obsolete
37356view21:50, 30 May 2010AmcuserPeriodical save, work in progress
37355view21:39, 30 May 2010AmcuserPeriodical save, work in progress
37313view21:50, 26 May 2010AmcuserPeriodical save, work in progress
37312view21:39, 26 May 2010AmcuserPeriodical save, work in progress
37311view21:28, 26 May 2010AmcuserPeriodical save, work in progress
37310view21:18, 26 May 2010AmcuserPeriodical save, work in progress
37309view21:07, 26 May 2010AmcuserPeriodical save, work in progress
37308view20:51, 26 May 2010AmcuserPeriodical save, work in progress
37307view17:21, 26 May 2010AmcuserPeriodical save, work in progress
37306view17:10, 26 May 2010AmcuserPeriodical save, work in progress
37304view16:14, 26 May 2010Amcuser26-5-2010
37277view21:10, 23 May 2010AmcuserPeriodical save, work in progress
37276view20:48, 23 May 2010AmcuserPeriodical save, work in progress
37275view20:37, 23 May 2010AmcuserPeriodical save, work in progress
37272view20:17, 23 May 2010AmcuserPeriodical save, work in progress
37271view20:04, 23 May 2010AmcuserPeriodical save, work in progress
37270view19:54, 23 May 2010AmcuserPeriodical save, work in progress
37269view19:43, 23 May 2010AmcuserPeriodical save, work in progress
37267view19:33, 23 May 2010AmcuserPeriodical save, work in progress
37266view19:22, 23 May 2010AmcuserPeriodical save, work in progress
37265view19:11, 23 May 2010AmcuserPeriodical save, work in progress
37264view19:00, 23 May 2010AmcuserPeriodical save, work in progress
37263view18:38, 23 May 2010AmcuserPeriodical save, work in progress
37262view18:28, 23 May 2010AmcuserPeriodical save, work in progress
37261view18:17, 23 May 2010AmcuserPeriodical save, work in progress
37260view18:07, 23 May 2010AmcuserPeriodical save, work in progress
37245view10:17, 23 May 2010AmcuserPeriodical save, work in progress
37238view20:48, 22 May 2010AmcuserPeriodical save, work in progress
37235view20:38, 22 May 2010AmcuserPeriodical save, work in progress
37234view20:27, 22 May 2010AmcuserPeriodical save, work in progress
37233view20:16, 22 May 2010AmcuserPeriodical save, work in progress
37232view20:06, 22 May 2010AmcuserPeriodical save, work in progress
37231view19:55, 22 May 2010AmcuserPeriodical save, work in progress
37230view19:35, 22 May 2010AmcuserPeriodical save, work in progress
37229view19:24, 22 May 2010AmcuserPeriodical save, work in progress
37228view19:14, 22 May 2010AmcuserPeriodical save, work in progress
37227view19:03, 22 May 2010AmcuserPeriodical save, work in progress
37226view18:53, 22 May 2010AmcuserPeriodical save, work in progress
37225view18:42, 22 May 2010AmcuserPeriodical save, work in progress
37224view18:12, 22 May 2010AmcuserPeriodical save, work in progress
37223view18:02, 22 May 2010AmcuserNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
AKT1GeneProduct207 (Entrez Gene)
AKT2GeneProduct208 (Entrez Gene)
AKT3GeneProduct10000 (Entrez Gene)
ARRB1GeneProduct408 (Entrez Gene) 11q13
ARRB2GeneProduct409 (Entrez Gene)
ATF2GeneProduct1386 (Entrez Gene) 2q32
ATF4GeneProduct468 (Entrez Gene)
BDNFGeneProduct627 (Entrez Gene)
BRAFGeneProduct673 (Entrez Gene)
CASP1GeneProduct834 (Entrez Gene)
CASP2GeneProduct835 (Entrez Gene)
CASP3GeneProduct836 (Entrez Gene) 4q34
CASP6GeneProduct839 (Entrez Gene)
CASP7GeneProduct840 (Entrez Gene)
CASP8GeneProduct841 (Entrez Gene)
CASP9GeneProduct842 (Entrez Gene)
CD14GeneProduct929 (Entrez Gene)
CDC25BGeneProduct994 (Entrez Gene)
CDC42GeneProduct998 (Entrez Gene) 1p 22.2 MB
CRKGeneProduct1398 (Entrez Gene)
CRKLGeneProduct1399 (Entrez Gene)
DAXXGeneProduct1616 (Entrez Gene)
DDIT3GeneProduct1649 (Entrez Gene)
DUSP10GeneProduct11221 (Entrez Gene)
DUSP1GeneProduct1843 (Entrez Gene)
DUSP4GeneProduct1846 (Entrez Gene)
DUSP5GeneProduct1847 (Entrez Gene)
DUSP6GeneProduct1848 (Entrez Gene)
DUSP7GeneProduct1849 (Entrez Gene)
ECSITGeneProduct51295 (Entrez Gene)
EGFGeneProduct1950 (Entrez Gene)
EGFRGeneProduct1956 (Entrez Gene)
ELK1GeneProduct2002 (Entrez Gene)
ELK4/Sap1aGeneProduct
FASGeneProduct355 (Entrez Gene)
FASLGGeneProduct356 (Entrez Gene)
FGF4GeneProduct2249 (Entrez Gene)
FLNAGeneProduct2316 (Entrez Gene)
FOSGeneProduct2353 (Entrez Gene)
GADD45AGeneProduct1647 (Entrez Gene)
GCKGeneProduct2645 (Entrez Gene)
GNA12GeneProduct2768 (Entrez Gene)
GRB2GeneProduct2885 (Entrez Gene)
HSPA1AGeneProduct3303 (Entrez Gene)
HSPA5GeneProduct3309 (Entrez Gene)
HSPA8GeneProduct3312 (Entrez Gene) 11q24
HSPB1GeneProduct3315 (Entrez Gene)
HSPB2GeneProduct3316 (Entrez Gene)
IKBKBGeneProduct3551 (Entrez Gene)
IKBKGGeneProduct8517 (Entrez Gene)
IL1AGeneProduct3552 (Entrez Gene)
IL1BGeneProduct3553 (Entrez Gene)
IL1R1GeneProduct3554 (Entrez Gene)
IL1R2GeneProduct7850 (Entrez Gene)
JUNGeneProduct3725 (Entrez Gene) 1p 59 Mb
JUNDGeneProduct3727 (Entrez Gene)
KRASGeneProduct3845 (Entrez Gene)
MAP2K1GeneProduct5604 (Entrez Gene)
MAP2K1IP1GeneProduct8649 (Entrez Gene)
MAP2K2GeneProduct5605 (Entrez Gene)
MAP2K4GeneProduct6416 (Entrez Gene) 17p11
MAP2K5GeneProduct5607 (Entrez Gene)
MAP2K6GeneProduct5608 (Entrez Gene)
MAP2K7GeneProduct5609 (Entrez Gene)
MAP3K11GeneProduct4296 (Entrez Gene)
MAP3K12GeneProduct7786 (Entrez Gene)
MAP3K13GeneProduct9175 (Entrez Gene)
MAP3K1GeneProduct4214 (Entrez Gene)
MAP3K14GeneProduct9020 (Entrez Gene)
MAP3K3GeneProduct171492 (Entrez Gene) 17q23
MAP3K4GeneProduct4216 (Entrez Gene)
MAP3K5GeneProduct4217 (Entrez Gene)
MAP3K6GeneProduct9064 (Entrez Gene)
MAP3K7GeneProduct6885 (Entrez Gene)
MAP3K7IP1GeneProduct10454 (Entrez Gene)
MAP3K7IP2GeneProduct23118 (Entrez Gene)
MAP3K8GeneProduct1326 (Entrez Gene)
MAP4K1GeneProduct11184 (Entrez Gene)
MAP4K3GeneProduct8491 (Entrez Gene) 2p22
MAP4K4GeneProduct9448 (Entrez Gene)
MAPK10GeneProduct5602 (Entrez Gene)
MAPK12GeneProduct6300 (Entrez Gene)
MAPK13GeneProduct5603 (Entrez Gene)
MAPK14GeneProduct1432 (Entrez Gene)
MAPK1GeneProduct5594 (Entrez Gene) 22q11
MAPK3GeneProduct5595 (Entrez Gene)
MAPK4GeneProduct5596 (Entrez Gene)
MAPK6GeneProduct5597 (Entrez Gene)
MAPK7GeneProduct5598 (Entrez Gene)
MAPK8GeneProduct5599 (Entrez Gene) JNK1, 10q11
MAPK8IP3GeneProduct23162 (Entrez Gene)
MAPK9GeneProduct5601 (Entrez Gene)
MAPKAPK2GeneProduct9261 (Entrez Gene)
MAPKAPK5GeneProduct8550 (Entrez Gene)
MAPTGeneProduct4137 (Entrez Gene)
MAXGeneProduct4149 (Entrez Gene)
MEF2CGeneProduct4208 (Entrez Gene)
MINK1GeneProduct50488 (Entrez Gene)
MOSGeneProduct4342 (Entrez Gene)
MRASGeneProduct22808 (Entrez Gene)
MYCGeneProduct4609 (Entrez Gene)
NF1GeneProduct4763 (Entrez Gene)
NFKB1GeneProduct4790 (Entrez Gene)
NGFBGeneProduct4803 (Entrez Gene)
NLKGeneProduct51701 (Entrez Gene)
NR4A1GeneProduct3164 (Entrez Gene)
NRASGeneProduct4893 (Entrez Gene)
NTF5GeneProduct4909 (Entrez Gene)
NTRK1GeneProduct4914 (Entrez Gene)
PAK1GeneProduct5058 (Entrez Gene)
PAK2GeneProduct5062 (Entrez Gene)
PDGFBGeneProduct5155 (Entrez Gene)
PDGFRBGeneProduct5159 (Entrez Gene)
PLA2G10GeneProduct8399 (Entrez Gene)
PLA2G5GeneProduct5322 (Entrez Gene)
PPM1AGeneProduct5494 (Entrez Gene)
PPM1BGeneProduct5495 (Entrez Gene) 2p21
PPP3CAGeneProduct5530 (Entrez Gene)
PPP3CBGeneProduct5532 (Entrez Gene) 10q21
PPP3CCGeneProduct5533 (Entrez Gene)
PPP3R1GeneProduct5534 (Entrez Gene)
PPP3R2GeneProduct5535 (Entrez Gene)
PPP5CGeneProduct5536 (Entrez Gene)
PRKACAGeneProduct5566 (Entrez Gene) 1p 82.2 MB
PRKCB1GeneProduct5579 (Entrez Gene)
PRKCDGeneProduct5580 (Entrez Gene)
PRKCGGeneProduct5582 (Entrez Gene)
PRKCHGeneProduct5583 (Entrez Gene)
PRKCZGeneProduct5590 (Entrez Gene)
PTPN5GeneProduct84867 (Entrez Gene)
PTPN7GeneProduct5778 (Entrez Gene)
PTPRRGeneProduct5801 (Entrez Gene)
RAC1GeneProduct5879 (Entrez Gene)
RAC2GeneProduct5880 (Entrez Gene)
RAF1GeneProduct5894 (Entrez Gene)
RAP1AGeneProduct5906 (Entrez Gene)
RAP1BGeneProduct5908 (Entrez Gene)
RASA1GeneProduct5921 (Entrez Gene)
RASA2GeneProduct5922 (Entrez Gene)
RASGRF2GeneProduct5924 (Entrez Gene)
RASGRP1GeneProduct10125 (Entrez Gene)
RASGRP4GeneProduct115727 (Entrez Gene)
RPS6KA3GeneProduct6197 (Entrez Gene)
SOS2GeneProduct6655 (Entrez Gene) 14q21
SRFGeneProduct6722 (Entrez Gene)
STK3GeneProduct6788 (Entrez Gene)
STMN1GeneProduct3925 (Entrez Gene)
TAOK1GeneProduct57551 (Entrez Gene)
TAOK2GeneProduct9344 (Entrez Gene) TAOK2= TAO Kinase, ser Thr kinase, binds microtubules, JNK and CASP mediates removal microtub-binding domain, nuclear transloc of TAOK2 and induction of apoptosis
TGFB1GeneProduct7040 (Entrez Gene)
TGFB2GeneProduct7042 (Entrez Gene)
TGFB3GeneProduct7043 (Entrez Gene)
TMEM37GeneProduct140738 (Entrez Gene)
TNFGeneProduct7124 (Entrez Gene)
TP53GeneProduct7157 (Entrez Gene)
TRAF2GeneProduct7186 (Entrez Gene)
TRAF6GeneProduct7189 (Entrez Gene)
ZAKGeneProduct51776 (Entrez Gene)
cAMPMetaboliteHMDB00058 (HMDB)
elk-1GeneProduct
fgfrGeneProduct
mkk3GeneProduct
mnk1/2GeneProduct
msk1/2GeneProduct
nfat2/4GeneProduct
sap1aGeneProduct

Annotated Interactions

No annotated interactions

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