p38 MAPK signaling pathway (Canis familiaris)

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1-8Growth Factors, UVTrophic Factors, etc.??DNA transcription?Right click for commentsCytokines Production,Apoptosis, etc.FASL, InflammatoryCytokines, UV, etc.TranslationStress: Osmotic shockg-radiation, Anisomycin?Apoptosis?ATF2PLA2G4ARASGRF1STAT1RPS6KA5RIPK1MAP2K6SHC1DAXXTRADDTGFBR1MAP2K4CDC42MAPKAPK5MAP3K7MKNK1MAPK14GRB2DDIT3MYCTRAF2MAPK14MAPKAPK2HRASHSPB1MAPKAPK2MAP3K5MAXELK1HMGN1RAC1TGFB2CREB1MEF2DMAP3K1MAP3K9


Description

p38 MAPKs are members of the MAPK family that are activated by a variety of environmental stresses and inflammatory cytokines. Stress signals are delivered to this cascade by members of small GTPases of the Rho family (Rac, Rho, Cdc42). As with other MAPK cascades, the membrane-proximal component is a MAPKKK, typically a MEKK or a mixed lineage kinase (MLK). The MAPKKK phosphorylates and activated MKK3/5, the p38 MAPK kinase. MKK3/6 can also be activated directly by ASK1, which is stimulated by apoptotic stimuli. P38 MAK is involved in regulation of Hsp27 and MAPKAP-2 and several transcription factors including ATF2, STAT1, THE Max/Myc complex, MEF-2, ELK-1 and indirectly CREB via activation of MSK1.

Comments

GenMAPP remarks 
Converted to human by GenMAPP.org
 
This pathway was inferred from Homo sapiens pathway WP400(r21524) with a 88% conversion rate.

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Quality Tags

Ontology Terms

 

Bibliography

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  1. Wysk M, Yang DD, Lu HT, Flavell RA, Davis RJ; ''Requirement of mitogen-activated protein kinase kinase 3 (MKK3) for tumor necrosis factor-induced cytokine expression.''; Proc Natl Acad Sci U S A, 1999 PubMed Europe PMC Scholia
  2. Lewis TS, Hunt JB, Aveline LD, Jonscher KR, Louie DF, Yeh JM, Nahreini TS, Resing KA, Ahn NG; ''Identification of novel MAP kinase pathway signaling targets by functional proteomics and mass spectrometry.''; Mol Cell, 2000 PubMed Europe PMC Scholia
  3. Ichijo H; ''From receptors to stress-activated MAP kinases.''; Oncogene, 1999 PubMed Europe PMC Scholia
  4. Roberson MS, Zhang T, Li HL, Mulvaney JM; ''Activation of the p38 mitogen-activated protein kinase pathway by gonadotropin-releasing hormone.''; Endocrinology, 1999 PubMed Europe PMC Scholia
  5. Herlaar E, Brown Z; ''p38 MAPK signalling cascades in inflammatory disease.''; Mol Med Today, 1999 PubMed Europe PMC Scholia
  6. Kyriakis JM; ''Making the connection: coupling of stress-activated ERK/MAPK (extracellular-signal-regulated kinase/mitogen-activated protein kinase) core signalling modules to extracellular stimuli and biological responses.''; Biochem Soc Symp, 1999 PubMed Europe PMC Scholia
  7. Li S, Wattenberg EV; ''Cell-type-specific activation of p38 protein kinase cascades by the novel tumor promoter palytoxin.''; Toxicol Appl Pharmacol, 1999 PubMed Europe PMC Scholia
  8. Tibbles LA, Woodgett JR; ''The stress-activated protein kinase pathways.''; Cell Mol Life Sci, 1999 PubMed Europe PMC Scholia

History

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CompareRevisionActionTimeUserComment
122865view08:06, 27 May 2022EgonwMade a pathway clickable
116820view10:16, 14 May 2021EweitzModified title
95738view13:24, 19 January 2018Mkutmonupdated homology conversion
95120view15:04, 16 November 2017Mkutmonadded missing homology converter comment source
68539view22:24, 5 July 2013MaintBotUpdated to 2013 gpml schema
67567view11:27, 26 June 2013DdiglesOntology Term : 'p38 MAPK signaling pathway' added !
40695view21:51, 1 March 2011MaintBotRemoved redundant pathway information and comments
38710view19:30, 23 September 2010AlexanderPico
38229view21:09, 27 August 2010KhanspersRemoved receptor and protein complex graphics
38228view21:08, 27 August 2010Khanspers
38189view23:05, 23 August 2010Khansperstest
38188view23:04, 23 August 2010Khanspers
38187view23:03, 23 August 2010KhanspersReverted to version '23:39, 12 February 2010' by Khanspers
38186view23:02, 23 August 2010Khanspers
35725view23:39, 12 February 2010KhanspersDescription and bibliography
33979view18:31, 9 December 2009MaintBotAutomatic update of empty xrefs
32253view12:56, 15 August 2009MaintBotFixed text labels
31771view12:08, 14 August 2009MaintBotFixed group labels
31275view20:00, 13 August 2009MaintBotFixed text labels
30723view22:56, 29 July 2009MaintBotNew pathway

External references

DataNodes

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NameTypeDatabase referenceComment
ATF2GeneProduct478806 (Entrez Gene)
CDC42GeneProduct607535 (Entrez Gene)
CREB1GeneProduct607922 (Entrez Gene)
DAXXGeneProduct474873 (Entrez Gene)
DDIT3GeneProduct607439 (Entrez Gene)
ELK1GeneProduct491860 (Entrez Gene)
GRB2GeneProduct483312 (Entrez Gene)
HMGN1GeneProduct
HRASGeneProduct
HSPB1GeneProduct403979 (Entrez Gene)
MAP2K4GeneProduct489508 (Entrez Gene)
MAP2K6GeneProduct480454 (Entrez Gene)
MAP3K1GeneProduct478061 (Entrez Gene)
MAP3K5GeneProduct476215 (Entrez Gene)
MAP3K7GeneProduct474996 (Entrez Gene)
MAP3K9GeneProduct490765 (Entrez Gene)
MAPK14GeneProduct403856 (Entrez Gene)
MAPKAPK2GeneProduct490263 (Entrez Gene)
MAPKAPK5GeneProduct477480 (Entrez Gene)
MAXGeneProduct609969 (Entrez Gene)
MEF2DGeneProduct
MKNK1GeneProduct482509 (Entrez Gene)
MYCGeneProduct403924 (Entrez Gene)
PLA2G4AGeneProduct480048 (Entrez Gene)
RAC1GeneProduct403955 (Entrez Gene)
RASGRF1GeneProduct488774 (Entrez Gene) PDZ domain containing guanine nucleotide exchange
RIPK1GeneProduct488195 (Entrez Gene) receptor (TNFRSF)-interacting serine-threonine kinase 1
RPS6KA5GeneProduct490831 (Entrez Gene)
SHC1GeneProduct490439 (Entrez Gene)
STAT1GeneProduct488449 (Entrez Gene)
TGFB2GeneProduct488596 (Entrez Gene)
TGFBR1GeneProduct481628 (Entrez Gene)
TRADDGeneProduct611262 (Entrez Gene)
TRAF2GeneProduct480673 (Entrez Gene)

Annotated Interactions

No annotated interactions
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