Complement and Coagulation Cascades (Gallus gallus)
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Muscle contraction,
Chemotaxis,
Phagocyte recruitment
Inflammation, etc.
C3b
Vascular injury
Cell adhesion,
migration,
profileration, etc
Degredation
C3a
Cell adhesion,
migration,
profileration, etc
Collagen,
basement membrane,
activated platelets, etc.
C3b/Bb
Cell lysis
C5a
Antibody/antigen
complex
C3b/4b, C3b, C3d
Platelet, monocyte,
lymphocyte,
endothelial cells,
smooth muscle cells
activation, etc
Thrombin
Complement Cascade
Alternative Pathway
Classical Pathway
Zymosan,
insulin, etc.
Mediators
Fibrinolytic system
C3
Convertase
Kinin kallikrein system
C4a
Clot
membrane attack complex
fibrin degredation
products
Cross-linked
fibrin polymer
Lectin Pathway
C4b/2a
Coagulation Cascade
Extrinsic pathway
MASP1
KLKB1
VWF
SERPINF2
F7
SERPINE1
F2
C4
CR2
SERPING1
CPB2
F10
MBL1
PROC
F12
SERPIND1
C3AR1
CRRY
CR1
SERPINA5
THBD
F2R
MCP
F3
PLAU
SERPINC1
F8
Bradykinin
F5
C6
Hc
PLAT
BDKRB1
109821
PLG
ADN
C1QA
PROS1
F9
C5AR1
CFI
TFPI
C8G
FGB
C9
C4BP
Daf2
MASP2
C1QB
C7
SERPINA1
Daf1
C1S
C1R
CD59A
C2
F13B
C1QC
C3
PLAUR
H2-BF
A2M
KNG1
CFH
Fibrin monomer
Description
No description
Comments
GenMAPP notes
http://www.genome.jp/dbget-bin/get
pathway?org name=mmu&mapno=04610
GenMAPP remarks
Adapted from KEGG (see notes)
HomologyConvert
This pathway was inferred from Homo sapiens pathway
WP558(r22582)
with a 58% conversion rate.
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Quality Tags
Ontology Terms
Saving...
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Bibliography
No bibliography
History
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Compare
Revision
Action
Time
User
Comment
122619
view
08:30, 22 April 2022
Ddigles
Reverted to version '03:59, 23 August 2016' by
Ddigles
122584
view
10:00, 18 April 2022
Eweitz
Modified title
89198
view
03:59, 23 August 2016
Ariutta
Ontology Term : 'hemostasis pathway' added !
89197
view
03:59, 23 August 2016
Ariutta
Ontology Term : 'coagulation cascade pathway' added !
89196
view
03:59, 23 August 2016
Ariutta
Ontology Term : 'complement system pathway' added !
74335
view
13:15, 13 April 2014
Egonw
Added a missing metabolite identifier.
68852
view
17:20, 8 July 2013
MaintBot
Updated to 2013 gpml schema
40990
view
22:55, 1 March 2011
MaintBot
Removed redundant pathway information and comments
38705
view
19:28, 23 September 2010
AlexanderPico
33912
view
18:04, 9 December 2009
MaintBot
Automatic update of empty xrefs
33491
view
15:11, 30 November 2009
MaintBot
Removed group label
31540
view
21:48, 13 August 2009
MaintBot
Fixed text labels
30389
view
21:05, 29 July 2009
MaintBot
New pathway
External references
DataNodes
View all...
Name
Type
Database reference
Comment
A2M
GeneProduct
418251 (Entrez Gene)
ADN
GeneProduct
BDKRB1
GeneProduct
772372 (Entrez Gene)
Bradykinin
Metabolite
C1QA
GeneProduct
419504 (Entrez Gene)
C1QB
GeneProduct
428197 (Entrez Gene)
C1QC
GeneProduct
419503 (Entrez Gene)
C1R
GeneProduct
418295 (Entrez Gene)
C1S
GeneProduct
418294 (Entrez Gene)
C2
GeneProduct
419574 (Entrez Gene)
C3
GeneProduct
396370 (Entrez Gene)
C3AR1
GeneProduct
418198 (Entrez Gene)
C4
GeneProduct
426611 (Entrez Gene)
C4BP
GeneProduct
C5AR1
GeneProduct
430484 (Entrez Gene)
C6
GeneProduct
431585 (Entrez Gene)
C7
GeneProduct
427187 (Entrez Gene)
MGI:88235 LL:109828
C8G
GeneProduct
770691 (Entrez Gene)
C9
GeneProduct
CD59A
GeneProduct
CFH
GeneProduct
429057 (Entrez Gene)
CFI
GeneProduct
428773 (Entrez Gene)
CPB2
GeneProduct
418851 (Entrez Gene)
CR1
GeneProduct
CR2
GeneProduct
CRRY
GeneProduct
Daf1
GeneProduct
Daf2
GeneProduct
F10
GeneProduct
395876 (Entrez Gene)
F12
GeneProduct
F13B
GeneProduct
424355 (Entrez Gene)
F2
GeneProduct
395306 (Entrez Gene)
F2R
GeneProduct
427212 (Entrez Gene)
F3
GeneProduct
429084 (Entrez Gene)
F5
GeneProduct
374052 (Entrez Gene)
F7
GeneProduct
395086 (Entrez Gene)
F8
GeneProduct
422199 (Entrez Gene)
F9
GeneProduct
374258 (Entrez Gene)
FGB
GeneProduct
373926 (Entrez Gene)
Fibrin monomer
Metabolite
H2-BF
GeneProduct
Hc
GeneProduct
KLKB1
GeneProduct
KNG1
GeneProduct
424957 (Entrez Gene)
MASP1
GeneProduct
407088 (Entrez Gene)
MASP2
GeneProduct
407089 (Entrez Gene)
MBL1
GeneProduct
MCP
GeneProduct
PLAT
GeneProduct
426791 (Entrez Gene)
PLAU
GeneProduct
396424 (Entrez Gene)
PLAUR
GeneProduct
PLG
GeneProduct
421580 (Entrez Gene)
PROC
GeneProduct
395085 (Entrez Gene)
PROS1
GeneProduct
418430 (Entrez Gene)
SERPINA1
GeneProduct
423434 (Entrez Gene)
SERPINA5
GeneProduct
423435 (Entrez Gene)
SERPINC1
GeneProduct
424440 (Entrez Gene)
SERPIND1
GeneProduct
395877 (Entrez Gene)
SERPINE1
GeneProduct
SERPINF2
GeneProduct
417561 (Entrez Gene)
SERPING1
GeneProduct
423132 (Entrez Gene)
TFPI
GeneProduct
423989 (Entrez Gene)
THBD
GeneProduct
428546 (Entrez Gene)
VWF
GeneProduct
419031 (Entrez Gene)
109821
GeneProduct
Annotated Interactions
No annotated interactions
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Try the New WikiPathways
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