p38 MAPK signaling pathway (Bos taurus)

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1-8Growth Factors, UVTrophic Factors, etc.?Cytokines Production,Apoptosis, etc.Translation?ApoptosisStress: Osmotic shockg-radiation, Anisomycin??Right click for commentsDNA transcriptionFASL, InflammatoryCytokines, UV, etc.?MAPK14RIPK1MAPK14CREB1MAP2K6DAXXTGFB2TGFBR1MYCHMGN1RASGRF1RPS6KA5CDC42TRADDATF2TRAF2MAXMAP3K1GRB2MAP3K9DDIT3MAPKAPK2PLA2G4AMAPKAPK5RAC1STAT1ELK1MAP3K7MAP2K4MEF2DMKNK1MAPKAPK2HSPB1HRASSHC1MAP3K5


Description

p38 MAPKs are members of the MAPK family that are activated by a variety of environmental stresses and inflammatory cytokines. Stress signals are delivered to this cascade by members of small GTPases of the Rho family (Rac, Rho, Cdc42). As with other MAPK cascades, the membrane-proximal component is a MAPKKK, typically a MEKK or a mixed lineage kinase (MLK). The MAPKKK phosphorylates and activated MKK3/5, the p38 MAPK kinase. MKK3/6 can also be activated directly by ASK1, which is stimulated by apoptotic stimuli. P38 MAK is involved in regulation of Hsp27 and MAPKAP-2 and several transcription factors including ATF2, STAT1, THE Max/Myc complex, MEF-2, ELK-1 and indirectly CREB via activation of MSK1.

Comments

GenMAPP remarks 
Converted to human by GenMAPP.org
 
This pathway was inferred from Homo sapiens pathway WP400(r21524) with a 86% conversion rate.

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Quality Tags

Ontology Terms

 

Bibliography

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  1. Ichijo H; ''From receptors to stress-activated MAP kinases.''; Oncogene, 1999 PubMed Europe PMC Scholia
  2. Lewis TS, Hunt JB, Aveline LD, Jonscher KR, Louie DF, Yeh JM, Nahreini TS, Resing KA, Ahn NG; ''Identification of novel MAP kinase pathway signaling targets by functional proteomics and mass spectrometry.''; Mol Cell, 2000 PubMed Europe PMC Scholia
  3. Tibbles LA, Woodgett JR; ''The stress-activated protein kinase pathways.''; Cell Mol Life Sci, 1999 PubMed Europe PMC Scholia
  4. Herlaar E, Brown Z; ''p38 MAPK signalling cascades in inflammatory disease.''; Mol Med Today, 1999 PubMed Europe PMC Scholia
  5. Wysk M, Yang DD, Lu HT, Flavell RA, Davis RJ; ''Requirement of mitogen-activated protein kinase kinase 3 (MKK3) for tumor necrosis factor-induced cytokine expression.''; Proc Natl Acad Sci U S A, 1999 PubMed Europe PMC Scholia
  6. Kyriakis JM; ''Making the connection: coupling of stress-activated ERK/MAPK (extracellular-signal-regulated kinase/mitogen-activated protein kinase) core signalling modules to extracellular stimuli and biological responses.''; Biochem Soc Symp, 1999 PubMed Europe PMC Scholia
  7. Roberson MS, Zhang T, Li HL, Mulvaney JM; ''Activation of the p38 mitogen-activated protein kinase pathway by gonadotropin-releasing hormone.''; Endocrinology, 1999 PubMed Europe PMC Scholia
  8. Li S, Wattenberg EV; ''Cell-type-specific activation of p38 protein kinase cascades by the novel tumor promoter palytoxin.''; Toxicol Appl Pharmacol, 1999 PubMed Europe PMC Scholia

History

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CompareRevisionActionTimeUserComment
116817view10:15, 14 May 2021EweitzModified title
95741view13:41, 19 January 2018Mkutmonupdated homology conversion
80992view14:02, 8 July 2015Mkutmonhomology conversion
67566view11:27, 26 June 2013DdiglesOntology Term : 'p38 MAPK signaling pathway' added !
63316view21:05, 9 May 2013MaintBotUpdated to 2013 gpml schema
40497view19:28, 1 March 2011MaintBotRemoved redundant pathway information and comments
38708view19:29, 23 September 2010AlexanderPico
38226view21:06, 27 August 2010Khanspers
38225view21:05, 27 August 2010KhanspersRemoved receptor graphics
35735view23:41, 12 February 2010KhanspersDescription and bibliography
33741view23:56, 8 December 2009MaintBotAutomatic update of empty xrefs
32506view12:50, 17 August 2009MaintBotFixed text labels
32196view12:36, 15 August 2009MaintBotFixed text labels
31675view11:43, 14 August 2009MaintBotFixed group labels
31204view19:34, 13 August 2009MaintBotFixed text labels
30606view22:17, 29 July 2009MaintBotNew pathway

External references

DataNodes

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NameTypeDatabase referenceComment
ATF2GeneProduct509827 (Entrez Gene)
CDC42GeneProduct532712 (Entrez Gene)
CREB1GeneProduct281713 (Entrez Gene)
DAXXGeneProduct504336 (Entrez Gene)
DDIT3GeneProduct777788 (Entrez Gene)
ELK1GeneProduct786886 (Entrez Gene)
GRB2GeneProduct535298 (Entrez Gene)
HMGN1GeneProduct785479 (Entrez Gene)
HRASGeneProduct513012 (Entrez Gene)
HSPB1GeneProduct516099 (Entrez Gene)
MAP2K4GeneProduct526469 (Entrez Gene)
MAP2K6GeneProduct286883 (Entrez Gene)
MAP3K1GeneProduct523962 (Entrez Gene)
MAP3K5GeneProduct537380 (Entrez Gene)
MAP3K7GeneProduct529146 (Entrez Gene)
MAP3K9GeneProduct
MAPK14GeneProduct534492 (Entrez Gene)
MAPKAPK2GeneProduct788091 (Entrez Gene)
MAPKAPK5GeneProduct535625 (Entrez Gene)
MAXGeneProduct540616 (Entrez Gene)
MEF2DGeneProduct
MKNK1GeneProduct525647 (Entrez Gene)
MYCGeneProduct511077 (Entrez Gene)
PLA2G4AGeneProduct525072 (Entrez Gene)
RAC1GeneProduct281440 (Entrez Gene)
RASGRF1GeneProductPDZ domain containing guanine nucleotide exchange
RIPK1GeneProduct504727 (Entrez Gene) receptor (TNFRSF)-interacting serine-threonine kinase 1
RPS6KA5GeneProduct504408 (Entrez Gene)
SHC1GeneProduct507196 (Entrez Gene)
STAT1GeneProduct510814 (Entrez Gene)
TGFB2GeneProduct534069 (Entrez Gene)
TGFBR1GeneProduct282382 (Entrez Gene)
TRADDGeneProduct504707 (Entrez Gene)
TRAF2GeneProduct512355 (Entrez Gene)

Annotated Interactions

No annotated interactions
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