TGF-beta signaling pathway (Bos taurus)

From WikiPathways

Revision as of 00:08, 9 December 2009 by MaintBot (Talk | contribs)
Jump to: navigation, search
GlycosylationPMNUEnzyme complexCYControlMolecular associationReceptorNUNUNUNUProteolytic cleavageNUMTCYNUAutophosphorylationCYCYNUNUDephosphorylationLigandEC(Protein-protein interaction)NUAcetylationCytoplasmNUMolecule in the pathwayInhibitionRecruitmentPalmitoylationEndoplasmic reticulumNUCYNUCYCYCYNUSumoylationERReaction through unknown mechanisms/moleculesCYCYCYNUNUPhosphorylationNUCYCYCYGlycosylationNUCYNUDeacetylationActivationCYNUCYUbiquitinationMethylationExtracellularNUNUCYMitochondriaNU -> CYCYAccession Number: NetPath 7; cellmap:7Golgi apparatusNUDesumoylationNucleusNU -> CYCYCYNUNUPlasma membraneCYDProteins in a complex interactionDemethylationENEndosomeGOTranslocationCYCYCYCYCYDeubiquitinationNUNUYAP1STAMBPL1CDC25AANAPC5TGFBR2ANAPC4SMURF1RBL1PIK3R2SMAD4SMAD7CCND1TGFB3TFDP1ANAPC2NUP153CAMK2ATGFB1HDAC1FOXH1RB1ROCK1STK11MEF2CTFDP2TGFBR2SMAD2CTNNB1SMAD4CDC27NFYCSMAD3BTRCTGFBR3E2F4BTRCSMAD3ARRB2NUP214PRKAR1BSP1RBX1LOC511264LOC100139910CTCFXPO1TGFBR3CDC16CCNE1UBE2D1TGFBR3GIPC1PIAS2RBL1TGFBR3TGFB3RBL2ANAPC7JUNBPRKCDFOSBDAB2EP300LEF1TGFBR2RB1TGFBR1SMAD3CCNB2KPNB1E2F4DVL1RBL1PIK3R1FOXG1HOXA9SMAD3TGFBR1ATF2SMAD4TGFB2SNX6ATF3CUL1ESR1E2F4CDC27MAP3K7IP1TGFBR2RUNX2CUL1ANAPC4ZEB1MAP2K6RBX1CAMK2BE2F5SMAD2AP2B1FOXO3MAP2K3SMAD2SUMO1CDC23SNX2TGFBR2LOC506618HNF4AMAPK8TGIF1TGFB1MAPK14SNX1CDC2STK11IPMYCSNIP1SNW1CDK2PPP2R2ARBL1STRAPTGFBR2TGFBR3ANAPC2MAP3K7UBE2D3ERBB2IPNFYASKILE2F4TFDP2COPS5SMURF2PIAS1CAMK2DJUNDEIF3ISMAD3HGSSTRAPDAXXCAMK2GE2F5TGFB2E2F5SMAD4AXIN2CDC16ETS1TFDP2KPNB1CREBBPTGFB3RB1MEF2ATGFB2SMAD3SDC2TGFBR2EID2ENGTGFB1E2F5TP53FOSSMAD4SMAD2ANAPC10ANAPC10TP73SMAD4AXIN1CDK6CDC27FZR1FNTAKAT2BPRKCBTFDP1E2F5TGFB1ESR1FKBP1AMAPK14ANAPC1CUL1SMAD7ANAPC1ACVRL1CDC23TFDP1UBE2D2HSPA8Gene SymbolROCK1SMAD6SNX6TGFBR1CDK4TGFBR2ARCAV1DCP1ATGFBR1RBX1MAPK8RBL2SMAD3ZFYVE9E2F4DCP1ATGFBR3FOXO4CDKN1ACD44JUNNFYBSPARCSMURF2CITED1SMAD7TGFB3ZFHX1BSMURF1LOC511264SMAD3NCOA1VDRPRKCGPARD3ANAPC7TRAP1E2F4SMAD3SNX4TGFBR2SKIRBL1E2F5ANAPC5TGFBR2


Description

No description

Comments

GenMAPP notes 
NetPath 7; cellmap:7 - TGF-beta Receptor Signaling Pathway

The TGF-beta Receptor Signaling pathway was kindly reviewed by Van Le Hong, Wei He and other members of Joan Massague’s lab. This cancer signaling pathway is available at Cancer Cell Map (http://cancer.cellmap.org) and NetPath (http://www.netpath.org) and is part of a collaborative project between the Computational Biology Center at Memorial Sloan-Kettering Cancer Center (http://cbio.mskcc.org), PandeyLab at Johns Hopkins University (http://pandeylab.igm.jhmi.edu) and Institute of Bioinformatics (http://www.ibioinformatics.org). If you use this pathway, you must cite the Cancer Cell Map and NetPath websites until the pathway is published.

GenMAPP remarks 
http://cancer.cellmap.org; http://www.netpath.org
HomologyConvert 
This pathway was inferred from Homo sapiens pathway WP366(r21445) with a 88% conversion rate.

Try the New WikiPathways

View approved pathways at the new wikipathways.org.

Quality Tags

Ontology Terms

 

Bibliography

  1. Kandasamy K, Mohan SS, Raju R, Keerthikumar S, Kumar GS, Venugopal AK, Telikicherla D, Navarro JD, Mathivanan S, Pecquet C, Gollapudi SK, Tattikota SG, Mohan S, Padhukasahasram H, Subbannayya Y, Goel R, Jacob HK, Zhong J, Sekhar R, Nanjappa V, Balakrishnan L, Subbaiah R, Ramachandra YL, Rahiman BA, Prasad TS, Lin JX, Houtman JC, Desiderio S, Renauld JC, Constantinescu SN, Ohara O, Hirano T, Kubo M, Singh S, Khatri P, Draghici S, Bader GD, Sander C, Leonard WJ, Pandey A; ''NetPath: a public resource of curated signal transduction pathways.''; Genome Biol, 2010 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
134490view05:07, 22 July 2024EgonwAdded two gene identifiers
134192view18:21, 16 July 2024EgonwRemoved template comments
117635view11:46, 21 May 2021EweitzModified title
115903view09:17, 20 March 2021EgonwCopied the NetPath paper into the literature list
115901view08:40, 20 March 2021EgonwModified description
113971view05:58, 14 December 2020EgonwModified title
90030view19:38, 8 October 2016AlexanderPicoModified description
87359view09:35, 22 July 2016MkutmonModified description
87358view09:35, 22 July 2016MkutmonModified description
87357view09:32, 22 July 2016MaintBotadded missing graphids
84565view11:36, 3 March 2016MkutmonReverted to version '15:24, 30 June 2015' by Mkutmon
84564view11:35, 3 March 2016Mkutmonadded missing graph ids
80745view15:24, 30 June 2015Mkutmonhomology conversion
63366view22:23, 9 May 2013MaintBotUpdated to 2013 gpml schema
40538view19:30, 1 March 2011MaintBotRemoved redundant pathway information and comments
33779view00:08, 9 December 2009MaintBotAutomatic update of empty xrefs
32510view12:51, 17 August 2009MaintBotFixed text labels
31208view19:36, 13 August 2009MaintBotFixed text labels
30614view22:19, 29 July 2009MaintBotNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
ACVRL1GeneProduct534536 (Entrez Gene)
ANAPC10GeneProduct783986 (Entrez Gene)
ANAPC1GeneProduct535565 (Entrez Gene)
ANAPC2GeneProduct
ANAPC4GeneProduct514572 (Entrez Gene)
ANAPC5GeneProduct540537 (Entrez Gene)
ANAPC7GeneProduct535072 (Entrez Gene)
AP2B1GeneProduct282183 (Entrez Gene)
ARGeneProduct280675 (Entrez Gene)
ARRB2GeneProduct281638 (Entrez Gene)
ATF2GeneProduct509827 (Entrez Gene)
ATF3GeneProduct515266 (Entrez Gene)
AXIN1GeneProduct504357 (Entrez Gene)
AXIN2GeneProduct511619 (Entrez Gene)
BTRCGeneProduct534072 (Entrez Gene)
CAMK2AGeneProduct530719 (Entrez Gene)
CAMK2BGeneProduct525416 (Entrez Gene)
CAMK2DGeneProduct532713 (Entrez Gene)
CAMK2GGeneProduct282162 (Entrez Gene)
CAV1GeneProduct281040 (Entrez Gene)
CCNB2GeneProduct281668 (Entrez Gene)
CCND1GeneProduct524530 (Entrez Gene)
CCNE1GeneProduct533526 (Entrez Gene)
CD44GeneProduct281057 (Entrez Gene)
CDC16GeneProduct614342 (Entrez Gene)
CDC2GeneProduct281061 (Entrez Gene)
CDC23GeneProduct512651 (Entrez Gene)
CDC25AGeneProduct520188 (Entrez Gene)
CDC27GeneProduct540660 (Entrez Gene)
CDK2GeneProduct519217 (Entrez Gene)
CDK4GeneProduct510618 (Entrez Gene)
CDK6GeneProduct511754 (Entrez Gene)
CDKN1AGeneProduct513497 (Entrez Gene)
CITED1GeneProduct282182 (Entrez Gene)
COPS5GeneProduct507179 (Entrez Gene)
CREBBPGeneProduct505453 (Entrez Gene)
CTCFGeneProduct517097 (Entrez Gene)
CTNNB1GeneProduct539003 (Entrez Gene)
CUL1GeneProduct539792 (Entrez Gene)
DAB2GeneProduct509221 (Entrez Gene)
DAXXGeneProduct504336 (Entrez Gene)
DCP1AGeneProduct783258 (Entrez Gene)
DVL1GeneProduct523325 (Entrez Gene)
E2F4GeneProduct525428 (Entrez Gene)
E2F5GeneProduct539427 (Entrez Gene)
EID2GeneProduct615269 (Entrez Gene)
EIF3IGeneProduct521747 (Entrez Gene)
ENGGeneProduct615844 (Entrez Gene)
EP300GeneProduct
ERBB2IPGeneProduct512866 (Entrez Gene)
ESR1GeneProduct407238 (Entrez Gene)
ETS1GeneProduct540313 (Entrez Gene)
FKBP1AGeneProduct539546 (Entrez Gene)
FNTAGeneProduct281169 (Entrez Gene)
FOSGeneProduct280795 (Entrez Gene)
FOSBGeneProduct540819 (Entrez Gene)
FOXG1GeneProduct516947 (Entrez Gene)
FOXH1GeneProduct493733 (Entrez Gene)
FOXO3GeneProduct535530 (Entrez Gene)
FOXO4GeneProduct618793 (Entrez Gene)
FZR1GeneProduct788406 (Entrez Gene)
GIPC1GeneProduct519617 (Entrez Gene)
Gene SymbolGeneProduct
HDAC1GeneProduct404126 (Entrez Gene)
HGSGeneProduct511582 (Entrez Gene)
HNF4AGeneProduct509200 (Entrez Gene)
HOXA9GeneProduct510459 (Entrez Gene)
HSPA8GeneProduct281831 (Entrez Gene)
JUNGeneProduct280831 (Entrez Gene)
JUNBGeneProduct514246 (Entrez Gene)
JUNDGeneProduct517192 (Entrez Gene)
KAT2BGeneProduct407215 (Entrez Gene)
KPNB1GeneProduct507804 (Entrez Gene)
LEF1GeneProduct535399 (Entrez Gene)
LOC100139910GeneProduct100139910 (Entrez Gene)
LOC506618GeneProduct506618 (Entrez Gene)
LOC511264GeneProduct511264 (Entrez Gene)
MAP2K3GeneProduct516039 (Entrez Gene)
MAP2K6GeneProduct286883 (Entrez Gene)
MAP3K7GeneProduct529146 (Entrez Gene)
MAP3K7IP1GeneProduct519958 (Entrez Gene)
MAPK14GeneProduct534492 (Entrez Gene)
MAPK8GeneProduct539941 (Entrez Gene)
MEF2AGeneProduct407231 (Entrez Gene)
MEF2CGeneProduct512254 (Entrez Gene)
MYCGeneProduct511077 (Entrez Gene)
NCOA1GeneProduct525346 (Entrez Gene)
NFYAGeneProduct539584 (Entrez Gene)
NFYBGeneProduct614382 (Entrez Gene)
NFYCGeneProduct534003 (Entrez Gene)
NUP153GeneProduct513270 (Entrez Gene)
NUP214GeneProduct784219 (Entrez Gene)
PARD3GeneProduct527964 (Entrez Gene)
PIAS1GeneProduct509231 (Entrez Gene)
PIAS2GeneProduct533403 (Entrez Gene)
PIK3R1GeneProduct282307 (Entrez Gene)
PIK3R2GeneProduct282308 (Entrez Gene)
PPP2R2AGeneProduct508045 (Entrez Gene)
PRKAR1BGeneProduct505370 (Entrez Gene)
PRKCBGeneProduct282325 (Entrez Gene)
PRKCDGeneProduct505708 (Entrez Gene)
PRKCGGeneProduct282002 (Entrez Gene)
RB1GeneProduct534712 (Entrez Gene)
RBL1GeneProduct524870 (Entrez Gene)
RBL2GeneProduct533294 (Entrez Gene)
RBX1GeneProduct518880 (Entrez Gene)
ROCK1GeneProduct785911 (Entrez Gene)
RUNX2GeneProduct
SDC2GeneProduct615785 (Entrez Gene)
SKIGeneProduct506127 (Entrez Gene)
SKILGeneProduct527910 (Entrez Gene)
SMAD2GeneProduct516010 (Entrez Gene)
SMAD3GeneProduct515125 (Entrez Gene)
SMAD4GeneProduct540248 (Entrez Gene)
SMAD6GeneProduct511279 (Entrez Gene)
SMAD7GeneProduct535916 (Entrez Gene)
SMURF1GeneProduct513902 (Entrez Gene)
SMURF2GeneProduct540826 (Entrez Gene)
SNIP1GeneProduct525944 (Entrez Gene)
SNW1GeneProduct326578 (Entrez Gene)
SNX1GeneProduct512029 (Entrez Gene)
SNX2GeneProduct509769 (Entrez Gene)
SNX4GeneProduct519597 (Entrez Gene)
SNX6GeneProduct532685 (Entrez Gene)
SP1GeneProduct540741 (Entrez Gene)
SPARCGeneProduct282077 (Entrez Gene)
STAMBPL1GeneProduct538785 (Entrez Gene)
STK11GeneProduct515245 (Entrez Gene)
STK11IPGeneProduct515395 (Entrez Gene)
STRAPGeneProduct510201 (Entrez Gene)
SUMO1GeneProduct788060 (Entrez Gene)
TFDP1GeneProduct534579 (Entrez Gene)
TFDP2GeneProduct506114 (Entrez Gene)
TGFB1GeneProduct282089 (Entrez Gene)
TGFB2GeneProduct534069 (Entrez Gene)
TGFB3GeneProduct538957 (Entrez Gene)
TGFBR1GeneProduct282382 (Entrez Gene)
TGFBR2GeneProduct535376 (Entrez Gene)
TGFBR3GeneProduct784894 (Entrez Gene)
TGIF1GeneProduct510050 (Entrez Gene)
TP53GeneProduct281542 (Entrez Gene)
TP73GeneProduct515105 (Entrez Gene)
TRAP1GeneProduct514472 (Entrez Gene)
UBE2D1GeneProduct535287 (Entrez Gene)
UBE2D2GeneProduct541003 (Entrez Gene)
UBE2D3GeneProduct
VDRGeneProduct533656 (Entrez Gene)
XPO1GeneProduct510568 (Entrez Gene)
YAP1GeneProduct617423 (Entrez Gene)
ZEB1GeneProduct535183 (Entrez Gene)
ZFHX1BGeneProduct
ZFYVE9GeneProduct613428 (Entrez Gene)

Annotated Interactions

No annotated interactions
Personal tools