MAPK cascade (Bos taurus)
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Activated
Rap1GAP
Apoptosis
Growth and Mitogenesis
Gq
Stress Activated Pathways
Gb and Gg
p38 MAPK Pathway
Nucleus
Gi
MAP2K7
MAP2
MAP3K2
PLCB3
GTP
SIPA1
RAF1
ARAF
MAP2K1
RASA3
MAP2K4
MAPK10
MAP3K3
MAPK12
MAP3K12
MAP3K1
GDP
MAP2K4
MBP
MAPK3
MAP2K6
RRAS
NRAS
HRAS
MAPK1
JUN
MAP2K2
KRAS
MAP2K3
MAPK14
ELK1
BRAF
RapGAPII
Description
No description
Comments
HomologyConvert
This pathway was inferred from Homo sapiens pathway
WP422(r21570)
with a 84% conversion rate.
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Quality Tags
Ontology Terms
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Bibliography
Plotnikov A, Zehorai E, Procaccia S, Seger R; ''The MAPK cascades: signaling components, nuclear roles and mechanisms of nuclear translocation.''; Biochim Biophys Acta, 2011
PubMed
Europe PMC
Scholia
Orton RJ, Sturm OE, Gormand A, Wolch W, Gilbert DR; ''Computational modelling reveals feedback redundancy within the epidermal growth factor receptor/extracellular-signal regulated kinase signalling pathway.''; IET Syst Biol, 2008
PubMed
Europe PMC
Scholia
History
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Compare
Revision
Action
Time
User
Comment
120345
view
07:25, 27 November 2021
Egonw
Made a pathway clickable
116824
view
10:17, 14 May 2021
Eweitz
Modified title
95769
view
14:24, 19 January 2018
Mkutmon
Homology conversion update
86847
view
14:54, 13 July 2016
Mkutmon
Ontology Term : 'mitogen activated protein kinase signaling pathway' added !
86841
view
13:33, 13 July 2016
Mkutmon
ontology tag fix
80699
view
15:22, 30 June 2015
Mkutmon
homology conversion
71415
view
19:01, 17 October 2013
MaintBot
Automated update of data sources
63370
view
23:06, 9 May 2013
MaintBot
Updated to 2013 gpml schema
62705
view
23:17, 1 May 2013
MaintBot
Updated UniProt data source
40542
view
19:31, 1 March 2011
MaintBot
Removed redundant pathway information and comments
33783
view
00:10, 9 December 2009
MaintBot
Automatic update of empty xrefs
32488
view
12:45, 17 August 2009
MaintBot
Fixed text labels
32183
view
12:32, 15 August 2009
MaintBot
Fixed text labels
31654
view
11:37, 14 August 2009
MaintBot
Fixed group labels
31186
view
19:28, 13 August 2009
MaintBot
Fixed text labels
30578
view
22:08, 29 July 2009
MaintBot
New pathway
External references
DataNodes
View all...
Name
Type
Database reference
Comment
ARAF
GeneProduct
540421 (Entrez Gene)
BRAF
GeneProduct
536051 (Entrez Gene)
ELK1
GeneProduct
786886 (Entrez Gene)
GDP
Metabolite
GTP
Metabolite
HRAS
GeneProduct
513012 (Entrez Gene)
JUN
GeneProduct
280831 (Entrez Gene)
KRAS
GeneProduct
541140 (Entrez Gene)
MAP2
GeneProduct
281294 (Entrez Gene)
MAP2K1
GeneProduct
533199 (Entrez Gene)
MAP2K2
GeneProduct
510434 (Entrez Gene)
MAP2K3
GeneProduct
516039 (Entrez Gene)
MAP2K4
GeneProduct
526469 (Entrez Gene)
MAP2K6
GeneProduct
286883 (Entrez Gene)
MAP2K7
GeneProduct
787278 (Entrez Gene)
MAP3K12
GeneProduct
505427 (Entrez Gene)
MAP3K1
GeneProduct
523962 (Entrez Gene)
MAP3K2
GeneProduct
504592 (Entrez Gene)
MAP3K3
GeneProduct
508943 (Entrez Gene)
MAPK10
GeneProduct
537631 (Entrez Gene)
MAPK12
GeneProduct
512943 (Entrez Gene)
MAPK1
GeneProduct
327672 (Entrez Gene)
MAPK14
GeneProduct
534492 (Entrez Gene)
MAPK3
GeneProduct
531391 (Entrez Gene)
MBP
GeneProduct
618684 (Entrez Gene)
NRAS
GeneProduct
506322 (Entrez Gene)
PLCB3
GeneProduct
515669 (Entrez Gene)
RAF1
GeneProduct
521196 (Entrez Gene)
RASA3
GeneProduct
282532 (Entrez Gene)
RRAS
GeneProduct
616503 (Entrez Gene)
RapGAPII
GeneProduct
SIPA1
GeneProduct
508234 (Entrez Gene)
not confirmed SwissProt ID - mu: SPA1 MOUSE
Annotated Interactions
No annotated interactions
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Try the New WikiPathways
View approved pathways at the new wikipathways.org.Quality Tags
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DataNodes
Annotated Interactions
No annotated interactions