Delta-Notch signaling pathway (Canis familiaris)

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CY->NULigandDephosphorylationDMolecule in the pathwayControlPalmitoylationNU->CYGOGene SymbolENRecruitmentProteins in a complex interactionCYICDNucleusECDGlycosylationDMitochondrionDPM->NUNUMTExtracellular(Protein-protein interaction)NU->CYCY->NUDemethylationAccession Number: NetPath 3; cellmap:3EndosomeCY->NUPM->NUAutophosphorylationDeacetylationUbiquitinationICDMethylation-- ICDICDInhibitionCY->NUAcetylationActivationPM->NUDGolgi apparatusPhosphorylationPMICDPM->CYGamma secretase complexIntracellular DomainNU->CYReceptorDGO->PMCY->NUICDTranslocationERGO->PMMolecular associationEnzyme complexEndoplasmic reticulumPM->NUDeubiquitinationProteolytic CleavageSumoylationDesumoylationCytoplasmICDPlasma membraneReactioin through unknown mechanisms/moleculesSTAT3NOTCH3HEY2JAG1JAG1HEY1RELALOC490882CUL1NCOR1SMAD4MAPK1YY1NCSTNNOTCH4FURINRBX1ADAM10LOC490882APH1AFBXW7MFNGSKP1LFNGSTAT3NOTCH1NFKBIAPIK3R2RELAAPH1BNOTCH1DLL1KAT2BSMAD3NCOR2PSENENGATA1AKT1MAML1RBPJGSK3BPSEN2EP300HIVEP3FHL1LOC487309LEF1POFUT1SMAD1NOTCH2MAGEA1SKP2DLL4SNW1JUNNOTCH2SKP1NOTCH1MEF2CTCF3HES5EGFPSEN1NCOR1PIK3R1RING1DTX1DTX1MAML3DLL1ITCHNOTCH1HES1SPENLOC475035CDK2SIN3ANOTCH4NOTCH3LCKCNTN1NOTCH1CNTFRSKP2EGFRCNTFASCL1LOC490882NUMBLWDR12SAP30APPJAG1HES6DLL4DLL1LOC478804JAK2LOC475083NOTCH2NUMBNOTCH1GSK3BNOTCH2NOTCH3TLE1MAPK3TP53MAML2EP300NCOR2ADAM17


Description

There are 4 Notch receptors in humans (Notch 1-4) that bind to a family of 5 ligands (Jagged 1 and 2 and Delta-like 1-3). The Notch receptors are expressed on the cell surface as heterodimeric proteins and their ligands are also membrane-bound. Signaling through the Notch receptors is triggered by ligand-binding that induces cleavage of the extracellular domain by an ADAM family metalloprotease followed by a cleavage within the transmembrane domain by gamma secretase complex. The second cleavage leads to translocation of the cytosolic domain of Notch receptors into the nucleus. Notch proteins are important in lineage specification and stem cell maintenance. Aberrant Notch signaling has been linked to a number of malignancies including leukemias, lymphomas and carcinomas of the breast, skin, lung, cervix and kidneys. Source: NetPath http://www.netpath.org/pathways?path_id=NetPath_3

Comments

GenMAPP notes 
NetPath 3; cellmap:3 - Delta-Notch Signaling Pathway.This cancer signaling pathway is available at Cancer Cell Map (http://cancer.cellmap.org) and NetPath (http://www.netpath.org) and is part of a collaborative project between the Computational Biology Center at Memorial Sloan-Kettering Cancer Center (http://cbio.mskcc.org), PandeyLab at Johns Hopkins University (http://pandeylab.igm.jhmi.edu) and Institute of Bioinformatics (http://www.ibioinformatics.org). If you use this pathway, you must cite the Cancer Cell Map and NetPath websites until the pathway is published.
GenMAPP remarks 
http://cancer.cellmap.org, http://www.netpath.org
HomologyConvert 
This pathway was inferred from Homo sapiens pathway WP61(r20805) with a 84% conversion rate.

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Bibliography

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History

View all...
CompareRevisionActionTimeUserComment
117992view11:23, 23 May 2021EweitzModified title
68507view21:50, 5 July 2013MaintBotUpdated to 2013 gpml schema
67148view10:12, 26 June 2013Christine ChichesterOntology Term : 'Notch signaling pathway' added !
40658view21:48, 1 March 2011MaintBotRemoved redundant pathway information and comments
35714view23:19, 12 February 2010AlexanderPico
33950view18:20, 9 December 2009MaintBotAutomatic update of empty xrefs
31291view20:07, 13 August 2009MaintBotFixed text labels
30749view23:06, 29 July 2009MaintBotNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
ADAM10GeneProduct478321 (Entrez Gene)
ADAM17GeneProduct475662 (Entrez Gene)
AKT1GeneProduct490878 (Entrez Gene)
APH1AGeneProduct483181 (Entrez Gene)
APH1BGeneProduct487589 (Entrez Gene)
APPGeneProduct403407 (Entrez Gene)
ASCL1GeneProduct482628 (Entrez Gene)
CDK2GeneProduct606931 (Entrez Gene)
CNTFGeneProduct483464 (Entrez Gene)
CNTFRGeneProduct442941 (Entrez Gene)
CNTN1GeneProduct477641 (Entrez Gene)
CUL1GeneProduct475512 (Entrez Gene)
DLL1GeneProduct
DLL4GeneProduct607575 (Entrez Gene)
DTX1GeneProduct
EGFGeneProduct403657 (Entrez Gene)
EGFRGeneProduct404306 (Entrez Gene)
EP300GeneProduct
FBXW7GeneProduct475465 (Entrez Gene)
FHL1GeneProduct492162 (Entrez Gene)
FURINGeneProduct488746 (Entrez Gene)
GATA1GeneProduct480906 (Entrez Gene)
GSK3BGeneProduct478575 (Entrez Gene)
HES1GeneProduct
HES5GeneProduct489614 (Entrez Gene)
HES6GeneProduct607298 (Entrez Gene)
HEY1GeneProduct403420 (Entrez Gene)
HEY2GeneProduct
HIVEP3GeneProduct
ITCHGeneProduct477199 (Entrez Gene)
JAG1GeneProduct485769 (Entrez Gene)
JAK2GeneProduct484185 (Entrez Gene)
JUNGeneProduct609429 (Entrez Gene)
KAT2BGeneProduct477052 (Entrez Gene)
LCKGeneProduct478151 (Entrez Gene)
LEF1GeneProduct478507 (Entrez Gene)
LFNGGeneProduct
LOC475035GeneProduct475035 (Entrez Gene)
LOC475083GeneProduct475083 (Entrez Gene)
LOC478804GeneProduct478804 (Entrez Gene)
LOC487309GeneProduct487309 (Entrez Gene)
LOC490882GeneProduct490882 (Entrez Gene)
MAGEA1GeneProduct
MAML1GeneProduct481457 (Entrez Gene)
MAML2GeneProduct485116 (Entrez Gene)
MAML3GeneProduct483814 (Entrez Gene)
MAPK1GeneProduct477575 (Entrez Gene)
MAPK3GeneProduct486758 (Entrez Gene)
MEF2CGeneProduct479155 (Entrez Gene)
MFNGGeneProduct610303 (Entrez Gene)
NCOR1GeneProduct479515 (Entrez Gene)
NCOR2GeneProduct486242 (Entrez Gene)
NCSTNGeneProduct488638 (Entrez Gene)
NFKBIAGeneProduct480291 (Entrez Gene)
NOTCH1GeneProduct480676 (Entrez Gene)
NOTCH2GeneProduct483148 (Entrez Gene)
NOTCH3GeneProduct610439 (Entrez Gene)
NOTCH4GeneProduct481726 (Entrez Gene)
NUMBGeneProduct480381 (Entrez Gene)
NUMBLGeneProduct612491 (Entrez Gene)
PIK3R1GeneProduct487235 (Entrez Gene)
PIK3R2GeneProduct609956 (Entrez Gene)
POFUT1GeneProduct609881 (Entrez Gene)
PSEN1GeneProduct403408 (Entrez Gene)
PSEN2GeneProduct490382 (Entrez Gene)
PSENENGeneProduct476479 (Entrez Gene)
RBPJGeneProduct479122 (Entrez Gene)
RBX1GeneProduct474494 (Entrez Gene)
RELAGeneProduct483729 (Entrez Gene)
RING1GeneProduct607905 (Entrez Gene)
SAP30GeneProduct607359 (Entrez Gene)
SIN3AGeneProduct478372 (Entrez Gene)
SKP1GeneProduct474682 (Entrez Gene)
SKP2GeneProduct489228 (Entrez Gene)
SMAD1GeneProduct475456 (Entrez Gene)
SMAD3GeneProduct610902 (Entrez Gene)
SMAD4GeneProduct476196 (Entrez Gene)
SNW1GeneProduct480405 (Entrez Gene)
SPENGeneProduct
STAT3GeneProduct490967 (Entrez Gene)
TCF3GeneProduct485079 (Entrez Gene)
TLE1GeneProduct476314 (Entrez Gene)
TP53GeneProduct403869 (Entrez Gene)
WDR12GeneProduct478876 (Entrez Gene)
YY1GeneProduct611171 (Entrez Gene)

Annotated Interactions

No annotated interactions
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