Regulation of actin cytoskeleton (Canis familiaris)

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Growth Factor (GF)Stabilizationof actinChemotatic factorGPCRActin polymerizationstress fiberFilipodiaGFFocal adhesion pathwayMAPK SignalingpathwayLamellipodiaPI3KPI3KRTKGPCRRTKActin polymerizationRASActin polymerization+p?-pFocal complexassemblyAdherens junction pathwayFocal adhesion pathwayGene ExpressionChemotactic factorRASActomyosinassembly contractionFocal adhesionassemblystress 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


Description

No description

Comments

GenMAPP notes 
http://www.genome.jp/kegg/pathway/hsa/hsa04810.html
GenMAPP remarks 
Adapted from KEGG (right-click to see notes)
HomologyConvert 
This pathway was inferred from Homo sapiens pathway WP51(r20783) with a 86% conversion rate.

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Quality Tags

Ontology Terms

 

Bibliography

No bibliography


History

View all...
CompareRevisionActionTimeUserComment
128552view04:35, 12 February 2024EweitzModified title
72086view21:21, 24 October 2013Mkutmonadded datasource to "Focal Adhesion pathway" and "MAPK Signaling pathway"
71469view19:17, 17 October 2013MaintBotAutomated update of data sources
68550view22:35, 5 July 2013MaintBotUpdated to 2013 gpml schema
48152view18:46, 9 May 2012MaintBotUpdating from human to fix xrefs
40707view21:51, 1 March 2011MaintBotRemoved redundant pathway information and comments
33987view18:33, 9 December 2009MaintBotAutomatic update of empty xrefs
32262view13:01, 15 August 2009MaintBotFixed text labels
31789view12:14, 14 August 2009MaintBotFixed group labels
31289view20:06, 13 August 2009MaintBotFixed text labels
30747view23:06, 29 July 2009MaintBotNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
ABI2GeneProduct488485 (Entrez Gene)
ACTBGeneProduct610787 (Entrez Gene)
ACTG1GeneProduct475923 (Entrez Gene)
ACTN1GeneProduct480369 (Entrez Gene)
APCGeneProduct479139 (Entrez Gene)
ARHGEF1GeneProduct
ARHGEF4GeneProduct483856 (Entrez Gene)
ARHGEF6GeneProduct610290 (Entrez Gene)
ARHGEF7GeneProduct485552 (Entrez Gene)
ARPC5GeneProduct480037 (Entrez Gene)
AcetylcholineMetabolite
Apc2GeneProduct485084 (Entrez Gene)
BAIAP2GeneProduct403473 (Entrez Gene)
BCAR1GeneProduct479648 (Entrez Gene)
BDKRB1GeneProduct490847 (Entrez Gene)
BDKRB2GeneProduct403658 (Entrez Gene)
BRAFGeneProduct475526 (Entrez Gene)
BradykininMetabolite
CD14GeneProduct607076 (Entrez Gene)
CDC42GeneProduct607535 (Entrez Gene)
CFL1GeneProduct476022 (Entrez Gene)
CFL2GeneProduct490649 (Entrez Gene)
CHRM1GeneProduct483776 (Entrez Gene)
CHRM2GeneProduct403858 (Entrez Gene)
CHRM3GeneProduct403827 (Entrez Gene)
CHRM4GeneProduct611314 (Entrez Gene)
CHRM5GeneProduct487472 (Entrez Gene)
CRKGeneProduct
CSKGeneProduct487649 (Entrez Gene)
CYFIP2GeneProduct479317 (Entrez Gene)
DOCK1GeneProduct486934 (Entrez Gene)
EGFGeneProduct403657 (Entrez Gene)
EGFRGeneProduct404306 (Entrez Gene)
ENAHGeneProduct
EZRGeneProduct484056 (Entrez Gene)
F2GeneProduct
F2RGeneProduct488942 (Entrez Gene)
FGD1GeneProduct491901 (Entrez Gene)
FGF10GeneProduct612454 (Entrez Gene)
FGF11GeneProduct607829 (Entrez Gene)
FGF12GeneProduct478676 (Entrez Gene)
FGF13GeneProduct492174 (Entrez Gene)
FGF14GeneProduct485537 (Entrez Gene)
FGF1GeneProduct607724 (Entrez Gene)
FGF16GeneProduct491974 (Entrez Gene)
FGF17GeneProduct607952 (Entrez Gene)
FGF18GeneProduct611641 (Entrez Gene)
FGF2GeneProduct
FGF20GeneProduct606908 (Entrez Gene)
FGF21GeneProduct484395 (Entrez Gene)
FGF22GeneProduct
FGF23GeneProduct611773 (Entrez Gene)
FGF3GeneProduct
FGF4GeneProduct483680 (Entrez Gene)
FGF5GeneProduct608459 (Entrez Gene)
FGF6GeneProduct486735 (Entrez Gene)
FGF7GeneProduct403915 (Entrez Gene)
FGF8GeneProduct403868 (Entrez Gene)
FGF9GeneProduct477340 (Entrez Gene)
FGFR1GeneProduct475582 (Entrez Gene)
FGFR2GeneProduct415125 (Entrez Gene)
FGFR3GeneProduct488808 (Entrez Gene)
FGFR4GeneProduct489095 (Entrez Gene)
FN1GeneProduct403845 (Entrez Gene)
GIT1GeneProduct491180 (Entrez Gene)
GNA12GeneProduct609567 (Entrez Gene)
GNA13GeneProduct490901 (Entrez Gene)
GNG12GeneProduct
GRLF1GeneProduct403543 (Entrez Gene)
GSNGeneProduct474819 (Entrez Gene)
HRASGeneProduct403735 (Entrez Gene)
IQGAP1GeneProduct479050 (Entrez Gene)
ITGA1GeneProduct489210 (Entrez Gene)
LIMK1GeneProduct489800 (Entrez Gene)
LOC442775GeneProduct
LOC477681GeneProduct477681 (Entrez Gene)
LOC487343GeneProduct487343 (Entrez Gene)
LPSMetaboliteC00338 (Kegg Compound)
MAP2K1GeneProduct478347 (Entrez Gene)
MAP2K2GeneProduct611939 (Entrez Gene)
MAPK1GeneProduct477575 (Entrez Gene)
MAPK3GeneProduct486758 (Entrez Gene)
MAPK4GeneProduct491690 (Entrez Gene)
MAPK6GeneProduct478311 (Entrez Gene)
MOSGeneProduct486959 (Entrez Gene)
MRASGeneProduct477082 (Entrez Gene)
MSNGeneProduct491924 (Entrez Gene)
MYH10GeneProduct479497 (Entrez Gene)
MYL1GeneProduct478896 (Entrez Gene)
MYL3GeneProduct476644 (Entrez Gene)
MYLKGeneProduct488012 (Entrez Gene)
NCKAP1GeneProduct478828 (Entrez Gene)
NRASGeneProduct403872 (Entrez Gene)
PAK1GeneProduct607885 (Entrez Gene)
PAK2GeneProduct612814 (Entrez Gene)
PAK3GeneProduct492067 (Entrez Gene)
PAK4GeneProduct484513 (Entrez Gene)
PAK6GeneProduct487490 (Entrez Gene)
PAK7GeneProduct485772 (Entrez Gene)
PDGFAGeneProduct491597 (Entrez Gene)
PDGFBGeneProduct442986 (Entrez Gene)
PDGFRAGeneProduct442860 (Entrez Gene)
PDGFRBGeneProduct442985 (Entrez Gene)
PFN1GeneProduct
PIK3C2AGeneProduct485399 (Entrez Gene)
PIK3C3GeneProduct490477 (Entrez Gene)
PIK3CAGeneProduct488084 (Entrez Gene)
PIK3CBGeneProduct477085 (Entrez Gene)
PIK3CDGeneProduct489644 (Entrez Gene)
PIK3CGGeneProduct483266 (Entrez Gene)
PIK3R1GeneProduct487235 (Entrez Gene)
PIK3R2GeneProduct609956 (Entrez Gene)
PIK3R3GeneProduct482512 (Entrez Gene)
PIK3R4GeneProduct477064 (Entrez Gene)
PIK3R5GeneProduct612805 (Entrez Gene)
PIP2MetaboliteC04637 (Kegg Compound)
PIP3MetaboliteC05981 (Kegg Compound)
PIP4K2AGeneProduct608414 (Entrez Gene)
PIP4K2BGeneProduct491034 (Entrez Gene)
PIP4K2CGeneProduct474417 (Entrez Gene)
PIP5K1AGeneProduct475846 (Entrez Gene)
PIP5K1BGeneProduct476331 (Entrez Gene)
PIP5K1CGeneProduct485054 (Entrez Gene)
PIP5KL1GeneProduct609122 (Entrez Gene)
PPP1R12AGeneProduct475411 (Entrez Gene)
PTK2GeneProduct475108 (Entrez Gene)
PXNGeneProduct486299 (Entrez Gene)
Pik3c2bGeneProduct478938 (Entrez Gene)
RAC1GeneProduct403955 (Entrez Gene)
RAC1P4GeneProduct
RAC2GeneProduct481271 (Entrez Gene)
RAC3GeneProduct
RAF1GeneProduct484648 (Entrez Gene)
RASSF7GeneProduct607151 (Entrez Gene)
RDXGeneProduct479446 (Entrez Gene)
RHOAGeneProduct403954 (Entrez Gene)
RHOXF2GeneProduct611154 (Entrez Gene)
ROCK1GeneProduct480181 (Entrez Gene)
ROCK2GeneProduct482970 (Entrez Gene)
RRAS2GeneProduct476865 (Entrez Gene)
RRASGeneProduct476413 (Entrez Gene)
SLC9A1GeneProduct478171 (Entrez Gene)
SOS1GeneProduct483042 (Entrez Gene)
SOS2GeneProduct490682 (Entrez Gene)
SSH1GeneProduct477526 (Entrez Gene)
SSH2GeneProduct491183 (Entrez Gene)
SSH3GeneProduct483699 (Entrez Gene)
TMSB4XGeneProduct
VAV1GeneProduct485016 (Entrez Gene)
VCLGeneProduct
VIL1GeneProduct488522 (Entrez Gene)
WASGeneProduct491867 (Entrez Gene)
WASF1GeneProduct475024 (Entrez Gene)

Annotated Interactions

No annotated interactions
Retrieved from "https://classic.wikipathways.org/index.php/Pathway:WP1178"
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