Alpha 6 beta 4 signaling (Homo sapiens)

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Laminin 1Nucleus(Protein-protein interaction)DCY->NUEndosomeInhibitionDCY->NURecruitmentMolecule in the pathwayMitochondrionMTPlasma membraneEndoplasmic reticulumLaminin 5Accession Number: NetPath 1; cellmap:1Golgi apparatusLaminin 11Proteins in a complex interactionCytoplasmDDMethylationDesumoylationCY->NULaminin 2PhosphorylationGene SymbolLigandDeubiquitinationECDEREnzyme complexTranslocationDeacetylationNULaminin 4ControlProteolytic cleavageDReceptorPalmitoylationDephosphorylationGOAutophosphorylationPMDLaminin 10SumoylationDemethylationAcetylationDMolecular AssociationExtracellularCYENActivationReaction through unknown mechanisms/moleculesCY->PMGlycosylationUbiquitinationMST1RABL1CASP3COL17A1SMAD3LAMB1MMP7TP73PIK3R1LAMA3BADITGA6DSPITGB4ITGB4CLCA1YWHAELAMC1ITGB4ITGB4IRS1GRB2SMAD3DSTITGA6LAMA2LAMC1EIF4EBP1RAC1PIK3R3ITGB4BPPTK2YES1YWHABITGA6SFNFRAP1LAMA1PIK3R2RHOALAMB1RHOALAMC1ERBB2LAMC1EGFRLAMB2PIK3CDITGA6LAMC2AKT1PIK3CBLAMB1ITGB4LAMB2VIMLAMR1NTN1EIF4EPLEC1SRCPRKCDARSMAD2IRS2CDKN1AITGA6PIK3CGITGA6YWHAHYWHAQLAMA2SMAD2FYNPRKCAYWHAZPIK3CACLCA2LAMB3PAK1LAMA5LAMC1SHC1RTKNCD151ITGB4BPERBINMETLAMA5ITGB4


Description

"Integrins are cell surface heterodimeric protein complex consisting of one alpha and one beta chain. Integrins act as cell adhesion molecules as well as participate in cellular signaling. The ligands of the alpha6 beta4 integrin are heterotrimers belonging to the laminin family including Laminin A2, Laminin B1, Laminin C1, Laminin A3, Laminin B3, Laminin C2, Laminin A5, Laminin A1 and Laminin B2 among others. Upon activation, the receptor is phosphorylated and associates with adaptor molecules Shc and Grb2, which then activate the PI 3-kinase/Akt, MAPK/NFkB and SMAD signaling modules." Source: http://www.netpath.org/pathways?path_id=NetPath_1

"The integrin alpha6-beta4 is a receptor for various Iaminin isofoms. It is strongly expressed on basal keratinocytes, in which it is concentrated in specialized adhesion structures called hemidesmosomes. Abnormal expression of the integrin alpha6-beta4 in the suprabasal cell layers has been associated with an increased malignancy of squamous cell carcinomas. The continued expression of alpha6-beta4, when cells leave the basement membrane and migrate into the upper layers, may contribute to a reduced dependence of growth on anchorage and thus to an increased cell proliferation. Recent studies have identified the alpha6-beta4 integrin as a sigalling molecule that rates proliferation in response to the interaction of cells with Iaminin." Source: Dr. A. Sonnenberg - http://www.onderzoekinformatie.nl/en/oi/nod/onderzoek/OND1270125/

Comments

GenMAPP notes 
NetPath 13: IL-1 Signaling Pathway

NetPath (http://www.netpath.org) is a collaborative project between PandeyLab at Johns Hopkins University (http://pandeylab.igm.jhmi.edu) and the Institute of Bioinformatics (http://www.ibioinformatics.org). If you use this pathway, you must cite the NetPath website until the pathway is published.

GenMAPP remarks 
http://www.netpath.org

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Bibliography

  1. Kandasamy K, Mohan SS, Raju R, Keerthikumar S, Kumar GS, Venugopal AK, Telikicherla D, Navarro JD, Mathivanan S, Pecquet C, Gollapudi SK, Tattikota SG, Mohan S, Padhukasahasram H, Subbannayya Y, Goel R, Jacob HK, Zhong J, Sekhar R, Nanjappa V, Balakrishnan L, Subbaiah R, Ramachandra YL, Rahiman BA, Prasad TS, Lin JX, Houtman JC, Desiderio S, Renauld JC, Constantinescu SN, Ohara O, Hirano T, Kubo M, Singh S, Khatri P, Draghici S, Bader GD, Sander C, Leonard WJ, Pandey A; ''NetPath: a public resource of curated signal transduction pathways.''; Genome Biol, 2010 PubMed Europe PMC Scholia

History

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CompareRevisionActionTimeUserComment
129701view01:22, 22 May 2024EweitzOntology Term : 'signaling pathway' added !
129680view00:46, 22 May 2024EweitzModified title
126340view09:03, 23 April 2023EgonwLicense is CCZero
120686view12:26, 23 December 2021EweitzStandardize font, weight, case
117645view11:42, 22 May 2021EweitzModified title
115920view16:59, 20 March 2021EgonwCopied the NetPath paper into the literature list
115915view14:44, 20 March 2021EgonwModified description
108319view20:44, 6 December 2019L DupuisConnected line
108318view20:44, 6 December 2019L DupuisConverted interactions to graphical lines in legend
85199view08:27, 25 April 2016EgonwReplaced a mim-conversion with Arrow.
78506view10:29, 7 January 2015MaintBotadded missing graphIds
72056view17:13, 24 October 2013Mkutmonupdated annotations for SOS1 and GRB2
71703view19:54, 17 October 2013MaintBotremoved data source from nodes without identifier
63141view19:17, 8 May 2013MaintBotUpdating GPML version
44947view12:32, 6 October 2011MartijnVanIerselOntology Term : 'integrin mediated signaling pathway' added !
44577view20:33, 20 September 2011MaintBotModified categories
44576view20:32, 20 September 2011MaintBot
44575view20:32, 20 September 2011MaintBotUpdating content to NetSlim
44117view20:47, 24 August 2011KhanspersReverted to version '23:41, 1 March 2011' by Khanspers
44044view23:33, 22 August 2011KhanspersModified description
44043view23:32, 22 August 2011KhanspersUpdating pathway from NetSlim
41155view23:41, 1 March 2011MaintBotRemoved redundant pathway information and comments
35307view00:07, 12 February 2010Nsalomonisconnected some lines
35298view23:12, 11 February 2010NsalomonisModified description
35283view22:44, 11 February 2010Nsalomonisin progress
35242view19:49, 11 February 2010NsalomonisModified description
21193view11:31, 14 November 2008MaintBot[[Pathway:Homo sapiens:Alpha6-Beta4-Integrin NetPath 1]] moved to [[Pathway:WP244]]: Moved to stable identifier
7896view13:46, 7 January 2008MaintBot[[Pathway:Human:Alpha6-Beta4-Integrin NetPath 1]] moved to [[Pathway:Homo sapiens:Alpha6-Beta4-Integrin NetPath 1]]: Renaming species
7573view16:00, 18 December 2007MaintBotfixed category names
7192view12:33, 4 November 2007MaintBotAdded categories to GPML
6896view12:04, 23 July 2007212.48.140.65
6293view22:17, 22 May 2007A.Pandeygpml file for [[Human:Alpha6-Beta4-Integrin_NetPath_1]]

External references

DataNodes

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NameTypeDatabase referenceComment
ABL1GeneProduct25 (Entrez Gene)
AKT1GeneProduct207 (Entrez Gene)
ARGeneProduct367 (Entrez Gene)
BADGeneProduct572 (Entrez Gene)
CASP3GeneProduct836 (Entrez Gene)
CD151GeneProduct977 (Entrez Gene)
CDKN1AGeneProduct1026 (Entrez Gene)
CLCA1GeneProduct1179 (Entrez Gene)
CLCA2GeneProduct9635 (Entrez Gene)
COL17A1GeneProduct1308 (Entrez Gene)
DSPGeneProduct1832 (Entrez Gene)
DSTGeneProduct667 (Entrez Gene)
EGFRGeneProduct1956 (Entrez Gene)
EIF4EGeneProduct1977 (Entrez Gene)
EIF4EBP1GeneProduct1978 (Entrez Gene)
ERBB2GeneProduct2064 (Entrez Gene)
ERBINGeneProduct55914 (Entrez Gene)
FRAP1GeneProduct2475 (Entrez Gene)
FYNGeneProduct2534 (Entrez Gene)
GRB2GeneProduct2885 (Entrez Gene)
IRS1GeneProduct3667 (Entrez Gene)
IRS2GeneProduct8660 (Entrez Gene)
ITGA6GeneProduct3655 (Entrez Gene)
ITGB4GeneProduct3691 (Entrez Gene)
ITGB4BPGeneProduct3692 (Entrez Gene)
LAMA1GeneProduct284217 (Entrez Gene)
LAMA2GeneProduct3908 (Entrez Gene)
LAMA3GeneProduct3909 (Entrez Gene)
LAMA5GeneProduct3911 (Entrez Gene)
LAMB1GeneProduct3912 (Entrez Gene)
LAMB2GeneProduct3913 (Entrez Gene)
LAMB3GeneProduct3914 (Entrez Gene)
LAMC1GeneProduct3915 (Entrez Gene)
LAMC2GeneProduct3918 (Entrez Gene)
LAMR1GeneProduct3921 (Entrez Gene)
METGeneProduct4233 (Entrez Gene)
MMP7GeneProduct4316 (Entrez Gene)
MST1RGeneProduct4486 (Entrez Gene)
NTN1GeneProduct9423 (Entrez Gene)
PAK1GeneProduct5058 (Entrez Gene)
PIK3CAGeneProduct5290 (Entrez Gene)
PIK3CBGeneProduct5291 (Entrez Gene)
PIK3CDGeneProduct5293 (Entrez Gene)
PIK3CGGeneProduct5294 (Entrez Gene)
PIK3R1GeneProduct5295 (Entrez Gene)
PIK3R2GeneProduct5296 (Entrez Gene)
PIK3R3GeneProduct8503 (Entrez Gene)
PLEC1GeneProduct5339 (Entrez Gene)
PRKCAGeneProduct5578 (Entrez Gene)
PRKCDGeneProduct5580 (Entrez Gene)
PTK2GeneProduct5747 (Entrez Gene)
RAC1GeneProduct5879 (Entrez Gene)
RHOAGeneProduct387 (Entrez Gene)
RTKNGeneProduct6242 (Entrez Gene)
SFNGeneProduct2810 (Entrez Gene)
SHC1GeneProduct6464 (Entrez Gene)
SMAD2GeneProduct4087 (Entrez Gene)
SMAD3GeneProduct4088 (Entrez Gene)
SRCGeneProduct6714 (Entrez Gene)
TP73GeneProduct7161 (Entrez Gene)
VIMGeneProduct7431 (Entrez Gene)
YES1GeneProduct7525 (Entrez Gene)
YWHABGeneProduct7529 (Entrez Gene)
YWHAEGeneProduct7531 (Entrez Gene)
YWHAHGeneProduct7533 (Entrez Gene)
YWHAQGeneProduct10971 (Entrez Gene)
YWHAZGeneProduct7534 (Entrez Gene)

Annotated Interactions

No annotated interactions
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