Vitamin A and carotenoid metabolism (Pan troglodytes)

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17, 23beta-caroteneROLbeta-caroteneROL=retinol; RAL=retinaldehyde, RA = retinoic acid, RE = retinyl ester, RPE = retinal pigment epithelium RAL?chylomicron9-cis RALbeta-carotene9-cis ROLPPAR pathwaysall-trans RARE + dietary lipids13,14 dehydro RAall-trans ROL?all-trans RALbeta-10'-apocarotenalROL-binding proteinsall-trans-4-oxo RA11-cis binding proteinLiver/other organs11-cis ROLBloodROLRE + dietary lipidsCytochrome P450 familyall-trans-4-oxo dehydro RA?beta-caroteneRE?13,14 dehydro RALNuclear receptors?13,14 dehydro ROL11-cis RALEnterocyteRA-binding proteinsRE + dietary lipidsRPE-specificNucleusRE?9-cis RALPLScarb1Sult1a1RARaVitamin D3RHOXF2Bcmo1LOC450857RBP1cryptoxanthinbeta-cryptoxanthinRDH8LOC450614RDH10Bcmo1Bcdo2RETSATNpc1l1RARGALDH1A2Abcg5RBP2lycopeneDHRS3ABCG8RBP4luteinRdh12LRATRDH5ALDH1A2ADH1ALOC738157RXRAviolaxanthinRpe65astaxanthinRXRGALDH1A1CRABP1LRATADH4CRABP2alpha-caroteneALDH1A3CD36BCMO1Rdh12ALDH1A3MAPKzeaxanthinRARBRXRBSCARB1RDH5RLBP1canthaxanthinRBP7SULT2B1ALDH1A13, 9, 154, 5, 11, 13, 16...1, 3, 7, 142, 6, 8, 10, 12...19


Description

This pathway is about carotenoid metabolism. It is mainly created by the NuGO focusteam on Carotenoid metabolism. Finally it was subject to a text mining workflow which added some additional entities.

Comments

HomologyConvert 
This pathway was inferred from Homo sapiens pathway WP716(r30274) with a 76% conversion rate.

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Quality Tags

Ontology Terms

 

Bibliography

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  1. Micozzi MS, Brown ED, Edwards BK, Bieri JG, Taylor PR, Khachik F, Beecher GR, Smith JC Jr; ''Plasma carotenoid response to chronic intake of selected foods and beta-carotene supplements in men.''; Am J Clin Nutr, 1992 PubMed Europe PMC Scholia
  2. Boosalis MG, Snowdon DA, Tully CL, Gross MD; ''Acute phase response and plasma carotenoid concentrations in older women: findings from the nun study.''; Nutrition, 1996 PubMed Europe PMC Scholia
  3. Olmedilla B, Granado F, Blanco I, Rojas-Hidalgo E; ''Seasonal and sex-related variations in six serum carotenoids, retinol, and alpha-tocopherol.''; Am J Clin Nutr, 1994 PubMed Europe PMC Scholia
  4. VandenLangenberg GM, Brady WE, Nebeling LC, Block G, Forman M, Bowen PE, Stacewicz-Sapuntzakis M, Mares-Perlman JA; ''Influence of using different sources of carotenoid data in epidemiologic studies.''; J Am Diet Assoc, 1996 PubMed Europe PMC Scholia
  5. Sies H, Stahl W, Sundquist AR; ''Antioxidant functions of vitamins. Vitamins E and C, beta-carotene, and other carotenoids.''; Ann N Y Acad Sci, 1992 PubMed Europe PMC Scholia
  6. Balmer JE, Blomhoff R; ''Gene expression regulation by retinoic acid.''; J Lipid Res, 2002 PubMed Europe PMC Scholia
  7. Huet F, Semama D, Maingueneau C, Charavel A, Nivelon JL; ''Vitamin A deficiency and nocturnal vision in teenagers with cystic fibrosis.''; Eur J Pediatr, 1997 PubMed Europe PMC Scholia
  8. Handelman GJ, Dratz EA, Reay CC, van Kuijk JG; ''Carotenoids in the human macula and whole retina.''; Invest Ophthalmol Vis Sci, 1988 PubMed Europe PMC Scholia
  9. Khachik F, Beecher GR, Goli MB, Lusby WR, Smith JC Jr; ''Separation and identification of carotenoids and their oxidation products in the extracts of human plasma.''; Anal Chem, 1992 PubMed Europe PMC Scholia
  10. Amir H, Karas M, Giat J, Danilenko M, Levy R, Yermiahu T, Levy J, Sharoni Y; ''Lycopene and 1,25-dihydroxyvitamin D3 cooperate in the inhibition of cell cycle progression and induction of differentiation in HL-60 leukemic cells.''; Nutr Cancer, 1999 PubMed Europe PMC Scholia
  11. Torma H, Rollman O, Binderup L, Michaelsson G; ''Vitamin D analogs affect the uptake and metabolism of retinol by human epidermal keratinocytes in culture.''; J Investig Dermatol Symp Proc, 1996 PubMed Europe PMC Scholia
  12. Hidiroglou M, Williams CJ; ''Interrelationships among liposoluble vitamins in ruminants.''; Am J Vet Res, 1986 PubMed Europe PMC Scholia
  13. Waagmeester A, Pezik P, Coort S, Tourniaire F, Evelo C, Rebholz-Schuhmann D; ''Pathway enrichment based on text mining and its validation on carotenoid and vitamin A metabolism.''; OMICS, 2009 PubMed Europe PMC Scholia
  14. Ruhl CE, Everhart JE; ''Relation of elevated serum alanine aminotransferase activity with iron and antioxidant levels in the United States.''; Gastroenterology, 2003 PubMed Europe PMC Scholia
  15. Bendich A, Olson JA; ''Biological actions of carotenoids.''; FASEB J, 1989 PubMed Europe PMC Scholia
  16. Johansson S, Melhus H; ''Vitamin A antagonizes calcium response to vitamin D in man.''; J Bone Miner Res, 2001 PubMed Europe PMC Scholia
  17. Czeczuga-Semeniuk E, Wolczynski S, Markiewicz W; ''Preliminary identification of carotenoids in malignant and benign neoplasms of the breast and surrounding fatty tissue.''; Neoplasma, 2003 PubMed Europe PMC Scholia

History

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CompareRevisionActionTimeUserComment
109360view13:49, 16 March 2020L DupuisConverted interaction lines to graphical lines
106935view13:40, 17 September 2019MaintBotHMDB identifier normalization
74498view16:00, 26 April 2014EgonwFixed a PubMed ID.
71665view19:40, 17 October 2013MaintBotAutomated update of data sources
69242view18:35, 8 July 2013MaintBotUpdated to 2013 gpml schema
58905view04:47, 21 February 2013MaintBotUpdated Ensembl and UniProt data source
48147view18:40, 9 May 2012MaintBotUpdating from human to fix xrefs
41547view01:58, 2 March 2011MaintBotRemoved redundant pathway information and comments
34278view21:57, 9 December 2009MaintBotAutomatic update of empty xrefs
32769view18:32, 4 September 2009MaintBotModified categories
30488view21:38, 29 July 2009MaintBotNew pathway

External references

DataNodes

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NameTypeDatabase referenceComment
ABCG8GeneProduct470363 (Entrez Gene)
ADH1AGeneProduct744064 (Entrez Gene)
ADH4GeneProduct461394 (Entrez Gene)
ALDH1A1GeneProduct464529 (Entrez Gene)
ALDH1A2GeneProduct746847 (Entrez Gene)
ALDH1A3GeneProduct453686 (Entrez Gene)
Abcg5GeneProduct
BCMO1GeneProduct468043 (Entrez Gene)
Bcdo2GeneProduct
Bcmo1GeneProduct468043 (Entrez Gene)
CD36GeneProduct463949 (Entrez Gene)
CRABP1GeneProduct740693 (Entrez Gene)
CRABP2GeneProduct469838 (Entrez Gene)
DHRS3GeneProduct737006 (Entrez Gene)
LOC450614GeneProduct450614 (Entrez Gene)
LOC450857GeneProduct450857 (Entrez Gene)
LOC738157GeneProduct738157 (Entrez Gene)
LPLGeneProduct464031 (Entrez Gene)
LRATGeneProduct471328 (Entrez Gene)
MAPKGeneProduct
Npc1l1GeneProduct463381 (Entrez Gene)
RARBGeneProduct745516 (Entrez Gene)
RARGGeneProduct451935 (Entrez Gene)
RARaGeneProduct454647 (Entrez Gene)
RBP1GeneProduct743893 (Entrez Gene)
RBP2GeneProduct743813 (Entrez Gene)
RBP4GeneProduct450617 (Entrez Gene)
RBP7GeneProduct746735 (Entrez Gene)
RDH10GeneProduct472795 (Entrez Gene)
RDH5GeneProduct467029 (Entrez Gene)
RDH8GeneProduct468716 (Entrez Gene)
RETSATGeneProduct470420 (Entrez Gene)
RHOXF2GeneProduct473763 (Entrez Gene)
RLBP1GeneProduct453635 (Entrez Gene)
RXRAGeneProduct464834 (Entrez Gene)
RXRBGeneProduct462601 (Entrez Gene)
RXRGGeneProduct457476 (Entrez Gene)
Rdh12GeneProduct
Rpe65GeneProduct744567 (Entrez Gene)
SCARB1GeneProduct452359 (Entrez Gene)
SULT2B1GeneProduct747360 (Entrez Gene)
Scarb1GeneProduct452359 (Entrez Gene)
Sult1a1GeneProduct
Vitamin D3MetaboliteHMDB00876 (hmdbid)
alpha-caroteneMetaboliteHMDB03993 (hmdbid)
astaxanthinMetaboliteHMDB02204 (hmdbid)
beta-cryptoxanthinMetaboliteHMDB02268 (hmdbid)
canthaxanthinMetaboliteHMDB03154 (hmdbid)
cryptoxanthinMetaboliteHMDB02268 (hmdbid)
luteinMetaboliteHMDB03233 (hmdbid)
lycopeneMetaboliteHMDB03000 (hmdbid)
violaxanthinMetaboliteHMDB03101 (hmdbid)
zeaxanthinMetaboliteHMDB02789 (hmdbid)

Annotated Interactions

No annotated interactions
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